Results 81 to 90 of about 14,813 (296)

Optimizing treatment protocols for spinal manipulative therapy: study protocol for a randomized trial

Trials, 2018
Background Low back pain is a common and costly condition. Spinal manipulative therapy (SMT) is a treatment supported in some guidelines, although most clinical trials examining SMT report small effect sizes.
Julie M. Fritz, Jason A. Sharpe, Elizabeth Lane, Doug Santillo, Tom Greene, Gregory Kawchuk   +5 more
doaj   +1 more source

An Online Model of International Clinical Mentoring for Novice Physical Therapists [PDF]

, 2018
Objectives: Clinical mentoring is important for novice clinicians as they are developing advanced critical-thinking skills. Research exploring innovative mentoring strategies to reduce barriers and enhance learning is needed.
Banks, Lora, Carney, Carolyn, Crane, Linda H, Hing, Wayne A, Kunker, Katrina, Magoon, Ashley, McGovern, Mary Claire, Sibold, Jeremy, Westervelt, Karen   +8 more
core   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Assignment of adverse event indexing terms in randomized clinical trials involving spinal manipulative therapy: an audit of records in MEDLINE and EMBASE databases

BMC Medical Research Methodology, 2017
Background Reporting of adverse events in randomized clinical trials (RCTs) is encouraged by the authors of The Consolidated Standards of Reporting Trials (CONSORT) statement.
Lindsay M. Gorrell, Roger M. Engel, Reidar P. Lystad, Benjamin T. Brown   +3 more
doaj   +1 more source

Spinal stenosis: A summary and review [PDF]

, 1993
A review of the etiology, clinical, radiological and laboratory presentation, differential diagnosis and management of spinal stenosis is presented.
Walker, B.F.
core   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Guidelines for the practice and performance of manipulation under anesthesia [PDF]

, 2014
BACKGROUND: There are currently no widely accepted guidelines on standards for the practice of chiropractic or manual therapy manipulation under anesthesia, and the evidence base for this practice is composed primarily of lower-level evidence.
Cheryl Hawk, Edward Cremata, Robert Gordon   +2 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Content validity of manual spinal palpatory exams - A systematic review [PDF]

, 2003
BACKGROUND: Many health care professionals use spinal palpatory exams as a primary and well-accepted part of the evaluation of spinal pathology. However, few studies have explored the validity of spinal palpatory exams.
Wadie I Najm, Michael A Seffinger, Shiraz I Mishra, Vivian M Dickerson, Alan Adams, Sibylle Reinsch, Linda S Murphy, Arnold F Goodman, GB Andersson, JD Loeser, NM Hadler, GB Andersson, RA Deyo, LG Hart, EH Schiotz, E Lomax, U Dinnar, BF Walker, BF Walker, RC Ward, L Chaitow, T Bergman, F Kaltenborn, K Lewit, C Wadsworth, WL Johnston, C Gonnella, DM Panzer, JC Keating Jr, M Haas, R Russell, J Alley, P Huijbregts, L Hestbaek, P van der Wurff, M Seffinger, G Winter, SJ Troyanovich, A Feinstein, G Jull, AF Kelso, J Vorro, AF Kelso, MC Beal, RS Tarr, SJ Troyanovich, SJ Troyanovich, WL Deville, P Juni, JJ Deeks, PG Shekelle, DJ Cook, B Koes, KF Schulz, P Juni, MC Beal, MC Beal, B Braun, DJ Brunarski, KW Bush, D Byfield, JM Cox, GA Dott, NA Ebraheim, SA Gracovetsky, P Gregory, M Haas, M Haas, A Jende, WL Johnston, G Jull, G Jull, G Kawchuk, L Keating, C Leboeuf-Yde, C Leboeuf-Yde, R Leclaire, G Lundberg, CG Maher, TG Mayer, JM McPartland, J Mennell, DD Nansel, KA Olson, SL Olson, PJ Osterbauer, DR Phillips, MJ Simmonds, B Swerdlow, R Tarr, AP Verhagen, E Viikari-Juntura, CM Visscher, J Vorro, J Vorro, J Vorro, D Harvey, P Kristiansson, H Sandmark, K Jensen, A Knottnerus, SL Olson, DD Price, EC Huskisson, L Keating, S Walter, D Moher, C Begg, D Moher   +108 more
core   +1 more source

Spinal manipulation or mobilization for lumbar disc herniation with radiculopathy : a protocol for a systematic review and meta-analysis [PDF]

, 2020
Introduction: The purpose of this study is to conduct a systematic review and meta-analysis into the effects of spinal manipulation or mobilization for Lumbar Disc Herniation with Radiculopathy (LDHR).
Danazumi, MS, Hassan, AB, Ibrahum, SU, Shehu, UT, Yakasai, AM, Zakari, UU   +5 more
core   +2 more sources