Results 31 to 40 of about 85,407 (260)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Rare Cause of Back Pain in a Paediatric Patient with Aneurysmal Bone Cyst: An Illustrative Case

Çocuk Dergisi
Spinal tumors are rare in the pediatric age. The most common symptoms of spinal tumors are neck, back, and waist pain. Diagnosis is often delayed in patients presenting with nonspecific symptoms (e.g. pain).
Aynur Kaya Karaca, Büşra Zeynep Yılmaz, Ahmet Osman Kılıç, Ganime Dilek Emlik, Mehmet Fatih Erdi   +4 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Carbon fiber rods in the treatment of cervical spine tumors: a case series and description of a novel surgical technique

Frontiers in Oncology
IntroductionConventional implant materials used in spinal tumor surgery, such as stainless steel and titanium, may interfere with the planning and delivery of radiotherapy, and pose difficulties for tumor imaging surveillance, due to the influence of ...
Simone Mazzoli, Jonathan Jiong Hao Tan, Jonathan Jiong Hao Tan, Gennaro Maria Scotto, James Thomas Patrick Decourcy Hallinan, Shilin Wang, Carmine Zoccali, Carmine Zoccali, Alessandro Luzzati   +8 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

THE SINS SCALE IN THE EVALUATION OF STABILITY IN PATIENTS WITH SPINAL METASTASIS

Coluna/Columna
Objective To evaluate the distribution of patients seen in the emergency care unit of the Instituto do Câncer do Estado de São Paulo in the categories “stable”, “indeterminate” and “unstable” as classified by the SINS scale. Methods The medical charts
ARIEL FALBEL LUGÃO, CLOVIS CASTANHO SILVEIRA JUNIOR, WILLIAM GEMIO JACOBSEN TEIXEIRA, ALEXANDRE FOGAÇA CRISTANTE   +3 more
doaj   +1 more source

Magnetic Resonance Imaging Features of Extradural Spinal Neoplasia in 60 Dogs and Seven Cats

Frontiers in Veterinary Science, 2021
This retrospective study describes the MRI features of extradural spinal neoplasia in 60 dogs and seven cats to identify potential distinguishing features between tumor classes and individual tumor types within each class.
Mylène Auger, Mylène Auger, Silke Hecht, Cary M. Springer   +3 more
doaj   +1 more source

Surgical management of metastatic spinal neoplasms

Neurosurgical Focus, 2003
Object In this study the authors retrospectively review outcomes in patients treated for metastases to the spine. Surgery for metastatic tumors to the spine remains an important part of the treatment armamentarium.
Frank D, Vrionis, John, Small
openaire   +2 more sources

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

A Technical Problem in Diagnosis Clarity of Solitary Spinal Cord Neurofibroma in an Eleven-month-old Boy

Folia Medica, 2017
Spinal neurofibroma is one of the rarest of the neoplasms involving the spinal cord or roots and occurs much less often than neurinoma, meningioma or glioma. The sixth pediatric case of solitary intramedullary tumor was described in 2013, according to B.
Poriazova Elena G., Boykinova Oliana B., Ivanov Ivan S., Spasova Maria I., Bozhilov Georgi B., Kevorkyan Ani K., Novakov Stoyan S.   +6 more
doaj   +1 more source