Results 61 to 70 of about 1,760,803 (361)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty [PDF]

, 2016
We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing ...
Anderson, K., Grant, A., Harrison, P., Kearns, R., Kinsella, J., Macfarlane, A., Puxty, K., Shaw, M.   +7 more
core   +1 more source

Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes

JOR Spine
Objectives The main objective of this study was to establish a mouse model of spinal ligament ossification to simulate the chronic spinal cord compression observed in patients with ossification of the posterior longitudinal ligament (OPLL).
Zhongyuan He, Tao Tang, Zhengya Zhu, Fuan Wang, Jianfeng Li, Fu Zhang, Nguyen Tran Canh Tung, Shaoyu Liu, Xizhe Liu, Zhiyu Zhou   +9 more
doaj   +1 more source

A causal examination of the correlation between hormonal and reproductive factors and low back pain

Frontiers in Endocrinology
BackgroundThe relationship between hormonal fluctuations in the reproductive system and the occurrence of low back pain (LBP) has been widely observed. However, the causal impact of specific variables that may be indicative of hormonal and reproductive ...
Dafu Chen, Jiaxiang Zhou, Chengkai Lin, Junhong Li, Zhengya Zhu, Xuezhi Rao, Jianmin Wang, Jianfeng Li, Hongkun Chen, Fuan Wang, Xianlong Li, Manman Gao, Manman Gao, Manman Gao, Manman Gao, Zhiyu Zhou, Zhiyu Zhou, Yongming Xi, Shufen Li   +18 more
doaj   +1 more source

Magnetic resonance imaging R2* sequences can better detect microstructural cartilage changes than T2 mapping in cynomolgus monkeys with limited knee kinematics: preliminary imaging findings

BMC Musculoskeletal Disorders, 2022
Background The difference between MRI (Magnetic resonance imaging)-R2* and T2 mapping sequences regarding their superiority in the detection of microstructural cartilage changes in knees with limited ROM (range of motion) was unknown. Methods Twenty male
ManMan Gao, JianMin Wang, LuoYong Jiang, XiMin Pan, Federico Canavese, YiQiang Li, WenTao Wang, ZhiYu Zhou, WeiMin Zhu   +8 more
doaj   +1 more source

Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury.

Neuron, 2021
Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal inflammation has not been determined.
J. Niehaus, B. Taylor-Blake, L. Loo, Jeremy M. Simon, M. Zylka   +4 more
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Selectivity in regeneration of the oculomotor nerve in the cichlid fish, Astronotus ocellatus [PDF]

, 1965
It has long been considered a general rule for nerve regeneration that the reinnervation of skeletal muscle is nonselective. Regenerating nerve fibers are supposed to reconnect with one skeletal muscle as readily as another according to studies covering ...
Arora, H. L., Sperry, R. W.
core  

Intraoperative Neurophysiological Monitoring for Endoscopic Endonasal Approaches to the Skull Base: A Technical Guide. [PDF]

, 2016
Intraoperative neurophysiological monitoring during endoscopic, endonasal approaches to the skull base is both feasible and safe. Numerous reports have recently emerged from the literature evaluating the efficacy of different neuromonitoring tests during
Doan, Adam T., Evans, James J., Kenning, Tyler J., Lober, Robert M., Matsumoto, Craig I., Singh, Harminder, Vogel, Richard W.   +6 more
core   +3 more sources