Results 91 to 100 of about 47,578 (306)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Diffusion tensor imaging at 3T for diagnosing root avulsion in adults with acute traumatic brachial plexus injuries

NeuroImage: Clinical
Background: Root avulsion in patients with traumatic brachial plexus injury (tBPI) are common and MRI is used to help identify patients who need urgent reconstruction.
Ryckie G. Wade, Irvin Teh, David Shelley, Robert D. Bains, James D. Bedford, Lucy E. Homer Newton, Chye Yew Ng, Grainne Bourke   +7 more
doaj   +1 more source

Recent advances in the management of brachial plexus injuries

Indian Journal of Plastic Surgery, 2014
Management of brachial plexus injury is a demanding field of hand and upper extremity surgery. With currently available microsurgical techniques, functional gains are rewarding in upper plexus injuries.
Prem Singh Bhandari, Sanjay Maurya
doaj   +1 more source

Diffuse Leptomeningeal Glioneuronal Tumor Involving Circle of Willis and Spinal Nerve Roots. [PDF]

Neurology, 2023
Lei X, Liu Y, Han F, Yu H, Deng C, He D.
europepmc   +1 more source

Axonal projections of Renshaw cells in the thoracic spinal cord [PDF]

, 2013
Renshaw cells are widely distributed in all segments of the spinal cord, but detailed morphological studies of these cells and their axonal branching patterns have only been made for lumbosacral segments.
Ford, TW, Saywell, SA, Kirkwood, PA
core  

Microsurgical anatomy of the denticulate ligaments and their relationship with the axilla of the spinal nerve roots

, 2014
The denticulate ligaments (DL), 20 or 21 pairs of meningeal extensions, spread from the lateral aspect of the spinal cord to the internal aspect of the spinal dura mater.
Suat Canbay, Hayrettin Okut, Cikla, Ulas, Tomer Hananya, Baskaya, Mustafa K., Gurer, Bora, Bozkurt, Melih, Okut, Hayrettin, Bora Gürer, Ulaş Cikla, Melih Bozkurt, Canbay, Suat, Mustafa K. Başkaya, Hananya, Tomer   +13 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Datasheet1_Patients having surgery for ulnar nerve compression at the elbow rarely have affection of the spinal nerve root at C8-Th1 levels.pdf

, 2022
Cervical pathology may contribute to residual problems after surgery for ulnar nerve compression. We aimed to evaluate the presence of pathological conditions in spinal cord and cervical spinal nerve roots in patients surgically treated for ulnar nerve ...
Lars B. Dahlin (14245229), Alice Giöstad (14245226), Erika Nyman (7325744), Kasim Abul-Kasim (8970173)   +3 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Predictors of indirect decompression in patients with monosegmental lumbar spinal stenosis

Хирургия позвоночника
Objective. To identify predictors of indirect decompression of spinal nerve roots in patients with degenerative monosegmental central spinal canal stenosis in the lumbar spine after isolated direct lateral interbody fusion (XLIF).
I.D. Isakov, A.J. Sanginov, E.A. Mushkachev, A.V. Peleganchuk   +3 more
doaj   +1 more source