Results 211 to 220 of about 47,578 (306)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Rare Case of a Cervical Ventral Root Filament Neuroma Mimicking a Sequestrated Disc Herniation in Association with Ossification of the Posterior Longitudinal Ligament. [PDF]

NMC Case Rep J
Akutagawa K, Tsurubuchi T, Miki S, Sakamoto N, Sekimoto R, Matsubara D, Ishikawa E.   +6 more
europepmc   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

A comprehensive review of the denticulate ligaments: application to surgery of the craniocervical junction and spine. [PDF]

Anat Cell Biol
Casteel AT, Dumont LM, Samrid R, Tabira Y, Raeburn K, Bubb K, Komune N, Dumont AS, Reina MA, Iwanaga J, Tubbs RS.   +10 more
europepmc   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Marked Cauda Equina Compression Secondary to Intervertebral Disc Protrusion Resulting in Severe Chronic Neuritis and Neural Fibrosis in a Dog. [PDF]

Case Rep Vet Med
Epstein E, Mooney A.
europepmc   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Cauda Equina Syndrome Associated with Dural Ectasia in Ankylosing Spondylitis: Case Report. [PDF]

Asian J Neurosurg
Jialuo L, Xiaoxing W, Hua G, Haonan Z, Xiaofeng C.   +4 more
europepmc   +1 more source

Homologous membrane wrapped ZIF‐8 nanoparticles accelerate differentiation of neural stem cell for spinal cord injury therapy

BMEMat, EarlyView.
Homologous membrane wrapped ZIF‐8 nanoparticles were proposed to improve biocompatibility and targeting ability to neural stem cells (NSCs). ZIF‐8‐SCM NPs exhibit pH responsiveness, thereby generating an intracellular Zn2+ storm to accelerate neural differentiation through calcium and MAPK signaling pathways. Moreover, they promote function recovery in
Jie Wang, Lusen Shi, Xinhui Liu, Zhong Zhuang, Zhichao Feng, Chunhui Sun, Jingang Wang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shuping Wang, Hengxing Zhou, Na Ren   +11 more
wiley   +1 more source

Biomechanical analysis of lumbar oblique manipulation for lumbar disc herniation with different protrusion subtypes. [PDF]

Mechanobiol Med
Zhang L, Deng Z, Zhang X, Wang K, Lin M, Yu Z, Zhan H, Zhao Y, Vrionis F, Wang H.   +9 more
europepmc   +1 more source