Results 261 to 270 of about 62,154 (329)

Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria. [PDF]

Nat Commun
Eli S, Rauso G, Ghezzi P, Szczerkowski JLA, Bruzzi M, Rizzelli F, Iommazzo F, Loffreda A, Castagna F, Donà F, Gaddoni C, Dondi A, Marenda M, Rodighiero S, Tournier P, Lavagnino Z, Parazzoli D, Gauthier NC, Tamburri S, Pasini D, Habib SJ, Mapelli M.   +21 more
europepmc   +1 more source

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, Volume 59, Issue 1, January 2026.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions. [PDF]

J Cell Biol
Avilov I, Horokhovskyi Y, Mehta P, Welp L, Jakobi J, Cai M, Orzechowski A, Urlaub H, Liepe J, Lenart P.   +9 more
europepmc   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, Volume 293, Issue 2, Page 396-417, January 2026.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

Nuances in the control of separase activity between mitosis and meiosis. [PDF]

PLoS Biol
Anger M.
europepmc   +1 more source

THE EFFECTS OF VITRIFICATION ON SPINDLE APPARATUS OF IN VITRO MATURED GERMINAL VESICLE IN MICE

, 2008
Mahmoudi Reza, Iraj Amiri, Parichehr Pasbakhsh, Iraj Ragerdi Kashani, Mahdi Abbasi, Abou Alhasani Farid, T Mehrannia, Aligholi Sobhani   +7 more
openalex   +1 more source

Comprehensive Statistical and Reliability Analysis for Safe Design Fatigue Life of Notched and Unnotched Al7075‐T6 Alloy

Fatigue &Fracture of Engineering Materials &Structures, Volume 49, Issue 1, Page 139-155, January 2026.
ABSTRACT Fatigue failure in aerospace structures is critically influenced by stress concentrators such as notches, which reduce service life and compromise safety. This study experimentally investigates the fatigue behavior of Al7075‐T6 alloy under rotating bending (R = −1, 60 Hz), considering notched and unnotched conditions.
U. A. Khashaba, Abdulkareem Alssayegh
wiley   +1 more source

Edaravone Mitigates Postovulatory Aging by Preserving Oocyte and Embryo Quality in Mice. [PDF]

Antioxidants (Basel)
Kim KH, Kim EY, Lee AR, Koong MK, Lee KA.   +4 more
europepmc   +1 more source