Results 31 to 40 of about 29,165 (264)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Grinding of TiC particle-reinforced steel-matrix composite GT35 with small diameter grinding rods

Jin'gangshi yu moliao moju gongcheng, 2022
Side milling experiments with small diameter grinding rods were carried out on TiC particle-reinforced steel-matrix composite to investigate the reasonable machining parameters and the cooling and lubrication conditions for this material, and to ...
Mengbo SHAO, Bochuan CHEN, Xiaoxing GAO, Songmei YUAN   +3 more
doaj   +3 more sources

Experimental Study on the Dynamic Performance of a New High-Speed Spindle Supported by Water-Lubricated Hybrid Bearings

Shock and Vibration, 2016
The dynamic performance of a new high-speed spindle supported by water-lubricated hybrid bearings is experimentally studied on a test rig. The present design allows the speed of the spindle up to 30,000 rpm, with a bearing internal diameter of 40 mm ...
Lin Wang, Hua Xu
doaj   +1 more source

Assessment of High Speed Spindle Accuracies

JOURNAL OF ADVANCES IN CHEMISTRY, 2017
The spindle error contributes to 25 percent of the error sources of the work piece in- accuracies. The 70 percent of the spindle errors are due to thermal errors that occurs in the spindle. The heat generation in high-speed built-in motorized spindle is of important concern in high speed machining.
Arun A P, Faizur Rahman A, Manivelmuralidaran V., Krishnamoorthi K.   +3 more
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Research on dynamic characteristics of motorized spindle based on comprehensive stiffness of angular contact ball bearing [PDF]

Mechanical Sciences
In order to study the dynamic performance of a motorized spindle system more accurately and to consider the centrifugal effect, thermal effect of the angular contact ball bearing (ACBB) caused by high speed and influence of temperature rise on the ...
B. Dong, C. Lei, K. Liu, R. Song, P. Cui
doaj   +1 more source

Theoretical investigation on nonlinear dynamic characteristic of spindle system

Advanced Composites Letters, 2020
Radial gap will occur at the spindle–tool holder interface when the spindle rotates at high speed. Therefore, the radial gap will lead to the nonlinear stiffness at the spindle–tool holder connection, and it will have effects on dynamic characteristic of
Xiangsheng Gao, Zeyun Qin, Min Wang, Yuming Hao, Ziyu Liu   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source