Results 51 to 60 of about 33,140 (265)
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
A thermally stable aerostatic spindle system equipped with self-cooling function
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014 High efficiency and high precision machining technologies have been recently required in a variety of industries. In general, aerostatic spindle systems can realize such machining, while at high speed rotation it generates a large amount of heat that ...
Yuuki TAMURA +3 more
doaj +1 more source
Predição do comportamento dinâmico de sistemas compostospor eixo-árvore, sistema de fixação e ferramenta de corte de máquinas ferramenta para altas velocidades (HSC) [PDF]
, 2006 Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2006.A predição de condições estáveis de corte é um dos requisitos críticos para a ...
Cardoso, Alexandre da Silva Paes
core
Numerical Investigation into Spindle System Stiffness of High-Speed Grinder
, 2011 This study was focused on the theoretical modeling and numerical investigation about the dynamic and static stiffness of spindle system of high speed grinder.
Wei Ping Mao, Chang He Li, Yu Cheng Ding
core +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
Advanced Science, EarlyView.PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao +7 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng +15 more
wiley +1 more source
Design of Special Fixture for Micro High Speed Motorized Spindle
, 2011 The fixture of motorized spindle significantly affect the vibration of micro high speed CNC milling machine, its performance can directly affect the machining accuracy of the entire micro milling machine. A special fixture of high-speed motorized spindle
Xiao Hong Lu +3 more
core +1 more source
Influence of polishing depth and spindle speed on surface roughness.
, 2022 Influence of polishing depth and spindle speed on surface roughness.
Yonggou Lou (13184178) +1 more
core +1 more source
Advanced Science, EarlyView.BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet +5 more
wiley +1 more source