Results 31 to 40 of about 8,755 (254)

Qualitative evaluation of kerf taper angle of conventionally drilled holes in glass fiber epoxy composite

Frontiers in Mechanical Engineering
This study analyses the impact of process parameters on Glass Fiber Reinforced Polymer (GFRP) components produced through conventional drilling on a CNC drilling machine (VMC). GFRP’s challenging machinability is due to its high strength-to-weight ratio,
Dipak S. Patil, Manmohan M. Bhoomkar, Neeraj Sunheriya, Jayant Giri, Jayant Giri, Jayant Giri, Atul Kulkarni, Lalit N. Patil, Lalit K. Toke, Thanikodi Sathish, Mohammad Kanan, Mohammad Kanan   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Hybrid Taguchi–Composite Scoring Approach Framework for Multi-Objective Optimization of Ring Spinning Process: Yarn Tension, Cop Diameter and Yarn Breakage Rate

Textiles
In this study, we investigate the optimization of ring spinning parameters affecting key yarn quality characteristics, including yarn tension, cop diameter, and end breakage.
Emilija Toshikj, Sijche Pechkova
doaj   +1 more source

Burr size investigation in micro milling of stainless steel 316L

International Journal of Lightweight Materials and Manufacture, 2019
Deburring of micro-parts is one of most complicated operations used in manufacturing of micro sized components. Therefore, restriction of burr formation is one of main objectives of micro-cutting processes.
Saeed Hajiahmadi
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Predictive Modeling of Thermally Assisted Machining and Simulation Based on RSM after WAAM

Metals, 2022
The WAAM (Wire Arc Additive Manufacturing) process is well-respected because of its low cost and high deposition efficiency; nevertheless, the process has the limitations of high heat input and low forming accuracy.
Hongyu Tian, Zhenyang Lu, Shujun Chen
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source