Results 41 to 50 of about 44,195 (310)

Surface roughness variation of thin wall milling, related to modal interactions [PDF]

, 2008
High-speed milling operations of thin walls are often limited by the so-called regenerative effect that causes poor surface finish. The aim of this paper is to examine the link between chatter instability and surface roughness evolution for thin wall ...
Assouline, Benardos, Bravo, Budak, Budak, Davies, Davies, Fofana, Gilles Dessein, Gradisek, Groover, Herranz, Lapoujoulade, Lionel Arnaud, Montgomery, Paris, Stout, Sébastien Seguy, Thevenot, Thevenot, Tobias, Zatarain   +21 more
core   +4 more sources

Qualitative evaluation of kerf taper angle of conventionally drilled holes in glass fiber epoxy composite

Frontiers in Mechanical Engineering
This study analyses the impact of process parameters on Glass Fiber Reinforced Polymer (GFRP) components produced through conventional drilling on a CNC drilling machine (VMC). GFRP’s challenging machinability is due to its high strength-to-weight ratio,
Dipak S. Patil, Manmohan M. Bhoomkar, Neeraj Sunheriya, Jayant Giri, Jayant Giri, Jayant Giri, Atul Kulkarni, Lalit N. Patil, Lalit K. Toke, Thanikodi Sathish, Mohammad Kanan, Mohammad Kanan   +11 more
doaj   +1 more source

Analysis of drilling force characteristics and trepanning tool wear during GFRP low frequency axial vibration drilling hole

Jin'gangshi yu moliao moju gongcheng, 2023
The processing damages such as delamination and tearing were easily produced during the drilling of the sleeve holes of GFRP, which were directly related to the axial drilling force. In order to improve the quality of GFRP hole-making, a new diamond thin-
Xianglong DONG, Lei ZHENG, Wendong WEI, Xiaohan SUN, Ziwen LIU, Yantao SUN, Zhiwei HE   +6 more
doaj   +1 more source

An analytical design method for milling cutters with nonconstant pitch to increase stability, part 2: Application [PDF]

, 2003
Chatter stability in milling can be improved significantly using variable pitch cutters. The pitch angles can be optimized for certain chatter frequency and spindle speed ranges using the analytical method presented in the first part of this two-part ...
Budak, Erhan
core   +2 more sources

Effect of cutting parameters on the dimensional accuracy and surface finish in the hard turning of MDN250 steel with cubic boron nitride tool, for developing a knowledged base expert system

International Journal of Mechanical and Materials Engineering, 2019
In the machining operations, final surface finish and dimensional accuracy are the most specified customer requirements. Hard turning machining operation using cubic boron nitride tool as an alternative of grinding process is a type of turning operation ...
Sasan Yousefi, Mehdi Zohoor
doaj   +1 more source

Experimental Investigation on Tribological Behaviour of AA6066: HSS-Cu Hybrid Composite in Dry Sliding Condition

Advances in Materials Science and Engineering, 2022
Aluminum is among the most preferred materials based on the desired properties. This investigation focused on to evaluate the wear rate of the AA6066 aluminium alloy composite by using pin-on-disc apparatus.
T. Sathish, L. Natrayan, S. Prasad Jones Christydass, S. Sivananthan, R. Kamalakannan, V. Vijayan, Prabhu Paramasivam   +6 more
doaj   +1 more source

Dynamic analysis of runout correction in milling [PDF]

, 2010
Tool runout and its effects is an important area of research within modelling, simulation, and control of milling forces. Tool runout causes tool cutting edges to experience uneven forces during milling.
Diez Cifuentes, Eduardo, Guzman Villaseñor, Mario, Perez Garcia, Hilde, Vizán Idoipe, Antonio   +3 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source