Results 151 to 160 of about 950,760 (352)

Moderators and mediators of pain and function outcomes in a new service delivery model for management of knee osteoarthritis in primary care (PARTNER): Secondary exploratory analysis of a randomized controlled trial

open access: yesArthritis Care &Research, Accepted Article.
Objective Explore moderators and mediators influenced changes in pain and function in people with knee osteoarthritis (OA) receiving a new model of primary care service delivery (PARTNER), at 12 months (ACTRN12617001595303). Methods Secondary analyses of a cluster randomized controlled trial comparing PARTNER to usual general practitioner‐delivered ...
Abdolhay Farivar   +12 more
wiley   +1 more source

Comparison of Safety and Efficacy of Anesthesia Methods in Percutaneous Endoscopic Lumbar Discectomy: A Network Meta-Analysis

open access: yesPain Research and Management
Conclusion: Local anesthesia, general anesthesia, and epidural anesthesia are all safe and effective methods for PELD. Local anesthesia has advantages in complications and operation time.
Bin Zheng   +3 more
doaj   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

open access: yesAdvanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim   +3 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

open access: yesAdvanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi   +4 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

open access: yesAdvanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang   +5 more
wiley   +1 more source

Optimal Acyclic Hamiltonian Path Completion for Outerplanar Triangulated st-Digraphs (with Application to Upward Topological Book Embeddings)

open access: yes, 2008
Given an embedded planar acyclic digraph G, we define the problem of "acyclic hamiltonian path completion with crossing minimization (Acyclic-HPCCM)" to be the problem of determining an hamiltonian path completion set of edges such that, when these edges
Mchedlidze, Tamara, Symvonis, Antonios
core  

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