Results 201 to 210 of about 425,515 (269)

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs. [PDF]

PLoS Pathog
Le NTT, Mercer RCC, Fang C, Sundaravadivelu A, Labadorf AT, Lin W, Kwan J, Blum B, Emili A, Harris DA.   +9 more
europepmc   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Defining Recurrent Lumbar Disc Herniation (RLDH): An International Survey Study. [PDF]

Global Spine J
Harhangi JS, Boeykens A, Dos Santos Rubio EJ, Morgenstern C, Burkhardt BW, Datar G, Lewandrowski KU, Harhangi BS.   +7 more
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Transient C5 Palsy After Full-Endoscopic Posterior Cervical Foraminotomy

Case Reports in Orthopedics
João Paulo Machado Bergamaschi, Ariel Falbel Lugão, Rangel Roberto de Assis, Kelsen de Oliveira Teixeira, Fernando Flores de Araújo, Thiago Queiroz Soares, Gustavo Vitelli Depieri, Álvaro Dowling, Robson Cruz de Oliveira, Fernanda Wirth, Fábio da Silva Forti, Helton Luiz Aparecido Defino   +11 more
doaj   +1 more source

Skeletal effects of JAK1/2 inhibition versu<i>s</i> IL-6 receptor blockade in rheumatoid arthritis: a <i>post hoc</i> comparative cohort analysis based on two prospective observational studies. [PDF]

Front Pharmacol
Schulz N, van Wijnen P, Wilhelmi T, Müller-Ladner U, Lange U, Klemm P.   +5 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Spine Injuries in the NBA: Return to Play Expectations After a Seasonal Injury. [PDF]

Orthop J Sports Med
Gill AK, Garg S, Young P, Gallizzi MA, Gill SS.   +4 more
europepmc   +1 more source

Nurse-led enhanced recovery care in spine surgery: a new frontier in patient-centric perioperative recovery. [PDF]

Patient Saf Surg
Arjmandnia F, Alimohammadi E.
europepmc   +1 more source