Results 191 to 200 of about 315,999 (305)

Septin5 deficiency impairs both recent and remote contextual fear memory. [PDF]

Mol Brain
Ageta-Ishihara N, Fukumasu N, Sakakibara K, Fujii K, Koshidaka Y, Katsuragawa S, Tanigaki K, Hiramoto T, Kang G, Hiroi N, Fukazawa Y, Miyakawa T, Takao K, Kinoshita M.   +13 more
europepmc   +1 more source

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Benign or aggressive? Understanding spinal melanocytomas in comparison to malignant melanoma. [PDF]

J Neurooncol
Ryba A, Mohme T, Kerschbaumer J, von Bronewski E, Hubertus V, Butenschoen VM, Kramer A, Stengel FC, Stienen MN, Battistelli M, Polli FM, Meyer HS, Dührsen L, Mende KC, Westphal M, Ringel F, Meyer B, Onken J, Thome C, Eicker SO, Mohme M.   +20 more
europepmc   +1 more source

Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.

Molecular Biology of the Cell, 2005
Takashi Nishimura, Tomoya Yamaguchi, A. Tokunaga, Akitoshi Hara, Tomonari Hamaguchi, Katsuhiro Kato, A. Iwamatsu, H. Okano, K. Kaibuchi   +8 more
semanticscholar   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Deficiency of Kif15 impairing synaptic development leads to mood disorder in mice. [PDF]

PLoS Genet
He X, Zhang W, Chen X, Dong Z, Wei C, Wu T, Kong D, Kong R, Wu R, Liu Y, Liu M.   +10 more
europepmc   +1 more source

Paralemmin-1, a modulator of filopodia induction is required for spine maturation.

Molecular Biology of the Cell, 2008
Pamela Arstikaitis, C. Gauthier-Campbell, Rosario Carolina Gutierrez Herrera, Kun Huang, J. Levinson, T. Murphy, M. Kilimann, C. Sala, M. A. Colicos, A. El-Husseini   +9 more
semanticscholar   +1 more source

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

Advanced Science, EarlyView.
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang, Yiming Liam Liu, Yidi Augenstern Du, Shan−Shan Wang, Bo O. Zhou   +4 more
wiley   +1 more source

Extensive multifocal extranodal diffuse large B-cell lymphoma involving parotid, breast, gastrointestinal tract, and dorsal spine: a case report. [PDF]

Ann Med Surg (Lond)
Shah SH, Ramzi SIUH, Qureshi HA, Gyawali J, Sattar W.   +4 more
europepmc   +1 more source