Results 221 to 230 of about 106,382 (258)

A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.

open access: yesAdvanced Science, EarlyView.
A novel transcriptional module involving CsYABBY3 and CsAS1 is identified to regulate cannabinoid biosynthesis and trichome development. These factors mutually activate each other and form a protein complex via a conserved residue, acting synergistically to amplify metabolic flux through a coordinate feed‐forward mechanism.
Xuewen Zhu   +18 more
wiley   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu   +11 more
wiley   +1 more source

The Lymphatic-Bone Axis in Cancer Metastasis. [PDF]

open access: yesCancers (Basel)
Lee A   +4 more
europepmc   +1 more source

Emerging Molecular Antiferroelectrics: Advances and Prospects

open access: yesAdvanced Science, EarlyView.
This review focuses on the current research progress in emerging molecular antiferroelectrics, encompassing their diverse structures, antiferroelectricity‐associated properties, and application exploration, including energy storage, electrocaloric refrigeration, and electrostriction.
Xiaoqi Li   +6 more
wiley   +1 more source

EVC protein regulates Sonic hedgehog signaling during human intervertebral disc development and degeneration. [PDF]

open access: yesiScience
Wu Z   +14 more
europepmc   +1 more source

Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence. [PDF]

open access: yesSci Adv
Egashira R   +8 more
europepmc   +1 more source

Genome-wide analysis reveals pathways important for the development and maturation of excitatory synaptic connections to GABAergic neurons. [PDF]

open access: yesG3 (Bethesda)
Oliver DB   +8 more
europepmc   +1 more source

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