Results 41 to 50 of about 354,367 (259)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Does the Spine Surgeon’s Experience Affect Fracture Classification, Assessment of Stability, and Treatment Plan in Thoracolumbar Injuries? [PDF]

, 2017
Study Design: Prospective survey-based study. Objectives: The AO Spine thoracolumbar injury classification has been shown to have good reproducibility among clinicians.
Chapman, Jens R., Dvorak, Marcel, Fehlings, Michael, Kandziora, Frank M., Kanna, Rishimugesh, Oner, Frank C., Rajasekaran, Shanmuganathan, Schnake, Klaus J., Schroeder, Gregory D., Shetty, Ajoy P., Vaccaro, Alex R., Vialle, Luiz   +11 more
core   +2 more sources

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Chylous Leak During Posterior Approach to Juvenile Scoliosis Surgery: A Case Report. [PDF]

, 2020
CaseWe report the first documented case of chylous leak recognized intraoperatively during posterior spinal instrumentation and fusion for juvenile scoliosis in a female patient with a history of thoracotomy and decortication for an empyema ...
Choi, Daniel E, Rynecki, Nicole, Sabharwal, Sanjeev, Sambol, Justin T, Shah, Harsh A, Vives, Michael J   +5 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Severity of Preoperative Cervical Disc Degeneration Is an Important Risk Factor for Cervical Fusion Failure After Anterior Cervical Discectomy and Fusion

International Journal of Clinical Practice
Conclusions: Patients with a higher preoperative D Score (> 23.5) and Mean Surgery D Score (> 4.125) have a higher risk of fusion failure after ACDF.
Bing Zhou, Youfeng Guo, Beiduo Shen, Haihong Zhao, Ziqi Zhu, Bin Yu, Tao Hu, Desheng Wu   +7 more
doaj   +1 more source

Thin presentation of knots and lens spaces

, 2003
This paper concerns thin presentations of knots K in closed 3-manifolds M^3 which produce S^3 by Dehn surgery, for some slope gamma. If M does not have a lens space as a connected summand, we first prove that all such thin presentations, with respect to ...
A Deruelle, Bailey, Cerf, D Matignon, Domergue, Gabai, Gordon, Gordon, Heath, Ichihara, Luecke, Matignon, Matveev, Moser, Neuwirth, Rolfsen, Teragaito, Thompson, Wallace   +18 more
core   +2 more sources

Physical Function and Quality of Life After Resection of Mobile Spine Chondrosarcoma. [PDF]

, 2019
Study Design:Retrospective cohort study. Objectives:(1) To assess patient-reported outcomes-physical function, pain, and quality of life-in patients who underwent resection of a mobile spine chondrosarcoma.
Chen, Yen-Lin E, DeLaney, Thomas F, Hartveldt, Stefan, Hornicek, Francis J, Janssen, Stein J, Paulino Pereira, Nuno Rui, Schwab, Joseph H, Stoop, Nicky   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Clinical Outcomes After Four-Level Anterior Cervical Discectomy and Fusion. [PDF]

, 2018
Study Design: Retrospective cohort study. Objectives: Anterior cervical discectomy and fusion (ACDF) demonstrates reliable improvement in neurologic symptoms associated with anterior compression of the cervical spine.
Hilibrand, Alan S, Hollern, Douglas A, Kepler, Christopher K, Kreitz, Tyler M, Padegimas, Eric M., Schroeder, Gregory D., Vaccaro, MD, PhD, Alexander   +6 more
core   +2 more sources