Results 31 to 40 of about 94,025 (220)
Depression and Clinical Progression in Spinocerebellar Ataxias [PDF]
Parkinsonism & Related Disorders, 2015 Background Depression is a common comorbidity in spinocerebellar ataxias (SCAs) but its association with ataxia progression is not well understood. Objectives To study the prevalence and influence of depressive symptoms in SCAs.
Raymond Y. Lo +18 more
semanticscholar +2 more sources
Muscle cramps profile among spinocerebellar ataxias [PDF]
Annals of Indian Academy of Neurology, 2022 Gustavo Leite Franklin +6 more
doaj +2 more sources
Nature Reviews Disease Primers, 2019 The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance and coordination accompanied by slurred speech; onset is most often in adult life. Genetically, SCAs are grouped as repeat expansion SCAs, such as SCA3/Machado-Joseph disease
Klockgether, Thomas +2 more
openaire +5 more sources
Ophthalmology, 2017 Recent work has demonstrated the importance of miRNAs in the pathogenesis of various brain disorders including the neurodegenerative disorder spinocerebellar ataxia (SCA). This review focuses on the role of miRNAs in the shared pathogenesis of the different SCA types.
Scott Wentz, Denis Jusufbegovic
openaire +4 more sources
Biomedicines, 2021 Polyglutamine (polyQ) ataxias are a heterogenous group of neurological disorders all caused by an expanded CAG trinucleotide repeat located in the coding region of each unique causative gene.
Craig S. McIntosh +3 more
doaj +1 more source
Neuropsychiatric symptoms in spinocerebellar ataxias and Friedreich ataxia.
Neuroscience and Biobehavioral Reviews, 2023 Apart from its role in motor coordination, the importance of the cerebellum in cognitive and affective processes has been recognized in the past few decades.
Karamazovova Simona +3 more
semanticscholar +1 more source
Hereditary ataxias: spinocerebellar ataxia type 2 (clinical case)
Актуальные проблемы теоретической и клинической медицины, 2022 This article will present a clinical case of a patient with hereditary spinocerebellar ataxia type 2 (SCA-type 2). Spinocerebellar ataxia is a group of hereditary progressive cerebellar ataxias, numbering over 40 subspecies, manifested in the form of ...
I. Em
doaj +1 more source
Movement Disorders, 2023 Intronic GAA repeat expansions in the fi broblast growth factor 14 gene ( FGF14 ) have recently been shown to be a common cause of adult-onset degenerative ataxia (spi-nocerebellar ataxia 27B [SCA27B], MIM: 620174), 1,2 but frequencies in strictly ...
H. Hengel +8 more
semanticscholar +1 more source
Rehabilitation in patients with cerebellar ataxias
Arquivos de Neuro-Psiquiatria, 2022 Cerebellar ataxias comprise a heterogeneous group of diseases characterized by motor and non-motor symptoms, which can be acquired, degenerative, or have a genetic cause, such as spinocerebellar ataxias (SCA).
Hsin Fen Chien +7 more
doaj +1 more source
Spinocerebellar ataxia type 14 (SCA14) in an Argentinian family: a case report
Journal of Medical Case Reports, 2023 Background Hereditary spinocerebellar ataxias are a group of genetic neurological disorders that result in degeneration of the cerebellum and brainstem, leading to difficulty in controlling balance and muscle coordination.
Niharika Duggirala +4 more
doaj +1 more source