Results 41 to 50 of about 94,025 (220)
Endurance exercise ameliorates phenotypes in Drosophila models of spinocerebellar ataxias
bioRxiv, 2021 Endurance exercise is a potent intervention with widespread benefits proven to reduce disease incidence and impact across species. While endurance exercise supports neural plasticity, enhanced memory, and reduced neurodegeneration, less is known about ...
A. Sujkowski +4 more
semanticscholar +1 more source
European Journal of Neurology, 2023 Dominantly inherited GAA repeat expansions in the fibroblast growth factor 14 (FGF14) gene have recently been shown to cause spinocerebellar ataxia 27B (SCA27B).
P. Iruzubieta +24 more
semanticscholar +1 more source
PLD3 and spinocerebellar ataxia [PDF]
Brain, 2018 sponsorship: Funding was provided by the Alzheimer Forschung Initiative e.V. (M.D.) and the Deutsche Forschungsgemeinschaft (GRK 1459) (P.S.). AC.G. is supported by the Hans & Ilse Breuer foundation. D.M. is supported by National Institutes of Health (NIH) grant R21AI126011. (Alzheimer Forschung Initiative e.V., Deutsche Forschungsgemeinschaft|GRK 1459,
Gonzalez, Adriana Carolina +8 more
openaire +4 more sources
Parkinsonism in Spinocerebellar Ataxia [PDF]
BioMed Research International, 2015 Spinocerebellar ataxia (SCA) presents heterogeneous clinical phenotypes, and parkinsonism is reported in diverse SCA subtypes. Both levodopa responsive Parkinson disease (PD) like phenotype and atypical parkinsonism have been described especially in SCA2, SCA3, and SCA17 with geographic differences in prevalence.
Park, Hyeyoung +2 more
openaire +2 more sources
Phenotypic and genetic aspects of hereditary ataxia in dogs
Journal of Veterinary Internal Medicine, 2023 Hereditary ataxias are a large group of neurodegenerative diseases that have cerebellar or spinocerebellar dysfunction as core feature, occurring as an isolated sign or as part of a syndrome.
Kimberley Stee +6 more
doaj +1 more source
Spinocerebellar Ataxia Type 2 [PDF]
, 2012 1. Introduction: The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders caused by degeneration of cerebellum and its afferent and efferent connections.
Georg Auburger +9 more
core +1 more source
Spinocerebellar ataxia: an update [PDF]
Journal of Neurology, 2018 Spinocerebellar ataxia (SCA) is a heterogeneous group of neurodegenerative ataxic disorders with autosomal dominant inheritance. We aim to provide an update on the recent clinical and scientific progresses in SCA where numerous novel genes have been identified with next-generation sequencing techniques. The main disease mechanisms of these SCAs include
Sullivan, R +3 more
openaire +3 more sources
Hereditary Cerebellar Ataxias: A Korean Perspective [PDF]
Journal of Movement Disorders, 2015 Hereditary ataxia is a heterogeneous disorder characterized by progressive ataxia combined with/without peripheral neuropathy, extrapyramidal symptoms, pyramidal symptoms, seizure, and multiple systematic involvements.
Ji Sun Kim, Jin Whan Cho
doaj +1 more source
The Spinocerebellar Ataxias [PDF]
Journal of Neuro-Ophthalmology, 2009 Slowly progressive ataxia accompanied by cerebellar degeneration is often genetic in origin. The past 15 years have witnessed a revolution in our understanding of the causes of dominantly inherited ataxias, now known as the spinocerebellar ataxias (SCAs). Nearly 30 distinct genetic causes of SCA are known, numbered chronologically in order of discovery.
openaire +2 more sources
Sleep disorders in cerebellar ataxias
Arquivos de Neuro-Psiquiatria, 2011 Cerebellar ataxias comprise a wide range of etiologies leading to central nervous system-related motor and non-motor symptoms. Recently, a large body of evidence has demonstrated a high frequency of non-motor manifestations in cerebellar ataxias ...
José L. Pedroso +6 more
doaj +1 more source