Results 51 to 60 of about 341,259 (167)

The m.14484T>C MT‐ND6 Mutation Presenting with a Hereditary Spastic‐Paraparesis Phenotype

Movement Disorders Clinical Practice, EarlyView.
Gabriel Amorelli, Christelle Nilles, Gerald Pfeffer, Matthew Joel, Davide Martino   +4 more
wiley   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) can be caused by autosomal‐dominant familial Alzheimer's disease (FAD) mutations in amyloid precursor protein (APP) or presenilin‐1 and 2, which form an enzyme substrate complex. KAT5 binds to the APP intracellular domain.
Greg A Cary, Jessica E. Young, Shannon E. Rose, Harald Frankowski, Heather Wilkins, Sai Sruthi Amirtha Ganesh, Julia Draper, Martin Darvas, Mark Bothwell, Suman Jayadev, Aquene N. Reid, Anna Greenwood, Allan I. Levey, Karina Leal, Gregory W. Carter, Jesse C. Wiley   +15 more
wiley   +1 more source

Primary cilia–extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria, Charisse N. Winston   +1 more
wiley   +1 more source

Nuclear dysfunction in aging and neurodegeneration

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Neurodegenerative diseases are characterized by a loss of neuronal function and structure, often in a region‐specific manner. Multiple factors contribute to neuronal dysfunction and death, including pathogenic protein buildup, protein mislocalization, and inflammation. Despite extensive research, the common mechanisms driving neurodegeneration
Abbigael Aday, Jack Tiller, Adarsh Melukote, Zachary C. Walton, Anna King, Luke Castillo, Rakez Kayed, Mauro Montalbano   +7 more
wiley   +1 more source

Mapping the Disrupted Connectome in Spinocerebellar Ataxia Type 3: A Network‐Based Statistics Study Identifying Novel Therapeutic Targets for Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This study identifies a dual pattern of structural and functional connectome disruption in SCA3 that correlates with clinical severity. Importantly, these abnormal structural connectivities are modulated by TMS, establishing them as promising imaging biomarkers and therapeutic targets for precision neuromodulation intervention.
Lan Ou, Chaoyang Zhou, Xingang Wang, Linfeng Shi, Peiling Ou, Chaodong Xiang, Hui Chen, Xi Chen, Bijia Wang, Wei Chen, Jian Wang, Zhiliang Long, Chen Liu   +12 more
wiley   +1 more source

Anesthetic management of a patient with spinocerebellar degeneration

Journal of Anaesthesiology Clinical Pharmacology, 2011
Spinocerebellar degeneration or olivopontocerebellar degeneration denotes a group of disorders of various etiologies manifesting as degenerative changes of various part of the central nervous system. We describe the anesthetic management of a patient with severe olivopontocerebellar degeneration posted for vaginal hysterectomy.
Prasanna Vadhanan, Pramod Kumar
openaire   +3 more sources

Disrupted Vestibular Nuclei Neuron Development in a Chick Model for Congenital Vestibular Disorders

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Children with syndromic, congenital vestibular disorders (CVDs) form a sac‐like inner ear with missing or truncated semicircular canals and experience delayed motor development with lifelong challenges to maintain posture and balance. How the abnormal inner ear affects downstream central vestibular neural circuitry has not been investigated ...
Elizabeth B. Bogin, Rossella Conti, Kathleen Gallagher, Kaya Oguz, Anastas Popratiloff, Kenna D. Peusner   +5 more
wiley   +1 more source

Estrés oxidativo y ataxias hereditarias

Revista Cubana de Investigaciones Biomédicas, 2003
Se revisó el estado actual de las enfermedades heredodegenerativas espinocerebelosas, las cuales conforman un conjunto de entidades cuyo rasgo nosológico mejor definido en la actualidad es su carácter hereditario.
Gretel Riverón Forment
doaj  

Usefulness of Information and Communication Technology‐Based Patient Information Sharing System in Supporting Patients With Intractable Neurological Diseases

Neurology and Clinical Neuroscience, Volume 14, Issue 4, Page 268-277, July 2026.
ABSTRACT Background Multidisciplinary collaboration is crucial for patients with incurable neurological diseases. However, sharing information among medical staff across institutions is challenging. Our cloud‐based patient information sharing system uses information and communication technology to facilitate the sharing of patient information among ...
Yui Kamijo, Akiyo Hineno, Gaku Okumura, Yoshiki Sekijima, Akinori Nakamura   +4 more
wiley   +1 more source