Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Advanced Science, Volume 13, Issue 4, 19 January 2026.Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
Estrés oxidativo y ataxias hereditarias
Revista Cubana de Investigaciones Biomédicas, 2003 Se revisó el estado actual de las enfermedades heredodegenerativas espinocerebelosas, las cuales conforman un conjunto de entidades cuyo rasgo nosológico mejor definido en la actualidad es su carácter hereditario.
Gretel Riverón Forment
doaj
Management of the ataxias : towards best clinical practice [PDF]
, 2016 This document aims to provide recommendations for healthcare professionals on the diagnosis and management of people with progressive ataxia. The progressive ataxias are rare neurological conditions, and are often poorly understood by healthcare ...
Bates, Claire +31 more
core +1 more source
Cerebellar Cortical Degeneration in Cattle Poisoned with Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review [PDF]
, 2020 Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb ...
Barros, Claudio S. L. +10 more
core +2 more sources
Unusual degenerative and environmental diseases seen in India [PDF]
, 1991 This article does not have an ...
Wadia, N. H.
core
Autosomal dominant cerebellar ataxia with retinal degeneration: clinical, neuropathologic, and genetic analysis of a large kindred. [PDF]
, 1994 Journal ArticleThe autosomal dominant cerebellar ataxias (ADCA) comprise a heterogeneous group of neurologic disorders characterized by degeneration of the cerebellum, spinal cord, and brainstem. Genetic analysis has revealed two loci, SCA1 on chromosome
Digre, Kathleen B.
core
Development of a Multidimensional Index of Fall Risk for Older Adults: The Cache County Study [PDF]
One out of four adults over the age of 65 are estimated to fall each year in the U.S. alone, with that number expected to rise to 52 million falls per year by the year 2030.
Hammond, Alexandra G.
core +2 more sources
Biotin levels in plasma of patients with Friedreich ataxia and other spinocerebellar degenerations [PDF]
, 1984 Berlit, Peter +2 more
core +1 more source
From mice to men: lessons from mutant ataxic mice [PDF]
, 2013 C.P. Snow, E. Jeauneau
core +1 more source
Experimental neurotransplantation treatment for hereditary cerebellar ataxias [PDF]
, 2016 Jan Cendelin
core +1 more source