Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission [PDF]
, 2014 We previously showed that gastrin-releasing peptide receptor (GRPR) in the spinal cord is important for mediating nonhistaminergic itch. Neuromedin B receptor (NMBR), the second member of the mammalian bombesin receptor family, is expressed in a largely ...
Barry, Devin M +12 more
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Impaired Autophagy of GABAergic Interneurons in Neuropathic Pain
Pain Research and Management, 2018 Neuropathic pain (NP) is caused by lesions of the peripheral fibers and central neurons in the somatosensory nervous system and affects 7–10% of the general population.
Yuhua Yin, Min-Hee Yi, Dong Woon Kim
doaj +1 more source
Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice. [PDF]
, 2019 Reelin (Reln) and Disabled-1 (Dab1) participate in the Reln-signaling pathway and when either is deleted, mutant mice have the same spinally mediated behavioral abnormalities, increased sensitivity to noxious heat and a profound loss in mechanical ...
Basbaum, Allan I +5 more
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Diagnostic sensitivity of traumatic axonal injury of the spinothalamic tract in patients with mild traumatic brain injury. [PDF]
Medicine (Baltimore), 2022 Jang SH, Kim SH, Kwon HG, Kwon HG.
europepmc +1 more source
Phosphorylation of ERK in Neurokinin 1 Receptor-Expressing Neurons in Laminae III and IV of the Rat Spinal Dorsal Horn Following Noxious Stimulation [PDF]
, 2007 Background There is a population of large neurons with cell bodies in laminae III and IV of the spinal dorsal horn which express the neurokinin 1 receptor (NK1r) and have dendrites that enter the superficial laminae. Although it has been shown that these
Erika Polgár +4 more
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Diffusion-weighted MRI in acute spinal cord ischaemia [PDF]
, 2018 : Acute spinal cord ischaemia is often undetectable with conventional MRI. Diffusion-weighted MRI (DWI) has been difficult to use in the spine because of susceptibility artefacts.
Arnold, M. +9 more
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Microglial deactivation by adeno-associated virus expressing small-hairpin GCH1 has protective effects against neuropathic pain development in a spinothalamic tract-lesion model. [PDF]
CNS Neurosci Ther, 2022 Jung HH +6 more
europepmc +1 more source
Functional MRI of the spinal cord at low field [PDF]
, 2004 A second contrast mechanism SEEP was reported to co-exist with BOLD during fMRI activation. The mechanism was based on the task-induced signal change of extravascular water protons and was primarily shown in the spinal cord at high field.
Hu, Y +5 more
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Surgical treatment of neuropathic pain [PDF]
, 2013 Neuropathic pain (NP) is a transient dysfunction caused by the damage of peripheral nerve and central nervous system, characterized with hyperalgesia, allodynia and spontaneous pain.
Zhi-pei LING, Zhi-qiang CUI
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Neuropathic Pain and Its Relationship with Quality of Life in 72 Patients with Spinal Cord Injury
Global Spine Journal, 2015 Introduction Approximately 80% of the patients with spinal cord injury (SCI) suffer from neuropathic pain. Some methods exist for evaluating neuropathic pain, but they have not been rigorously validated.
Narihito Nagoshi, Masaya Nakamura
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