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Traumatic Axonal Injury: Mechanisms and Translational Opportunities [PDF]
Trends in Neurosciences, 2016 Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain injury (TBI) and a major driver of mortality and functional impairment. Experimental models have provided insights into the effects of mechanical deformation on the neuronal cytoskeleton and the subsequent processes that drive axonal injury.
Ciaran Hill, Michael P Coleman
exaly +9 more sources
The Role of Novel Imaging and Biofluid Biomarkers in Traumatic Axonal Injury: An Updated Review [PDF]
Biomedicines, 2023 Traumatic brain injury (TBI) is a leading cause of disability worldwide. Traumatic axonal injury (TAI) is a subtype of TBI resulting from high-impact forces that cause shearing and/or stretching of the axonal fibers in white matter tracts.
Marios Lampros +6 more
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Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretch in vitro [PDF]
Frontiers in Cellular Neuroscience, 2023 Introduction:In vitro models of traumatic brain injury (TBI) commonly use neurons isolated from the central nervous system. Limitations with primary cortical cultures, however, can pose challenges to replicating some aspects of neuronal injury associated
Alexandra A. Adams +5 more
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Applied Sciences, 2022 Traumatic brain injury (TBI) is one of the leading causes of death worldwide, particularly in young people. Diffuse axonal injuries (DAI) are the result of strong rotational and translational forces on the brain parenchyma, leading to cerebral oedema and
Iuliana Hunea +10 more
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Neural Regeneration Research, 2021 Millions of people worldwide are affected by traumatic spinal cord injury, which usually results in permanent sensorimotor disability. Damage to the spinal cord leads to a series of detrimental events including ischaemia, haemorrhage and ...
Alba Guijarro-Belmar +4 more
doaj +1 more source
Neural Regeneration Research, 2020 Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported.
Jun-Jie Zhao +6 more
doaj +1 more source
Frontiers in Neurology, 2020 Traumatic brain injury is a major global cause of death and disability. Axonal injury is a major underlying mechanism of TBI and could represent a major therapeutic target.
Ciaran S. Hill +8 more
doaj +1 more source
Neural Regeneration Research, 2022 The main advantage of diffusion tensor tractography is that it allows the entire neural tract to be evaluated. In addition, configurational analysis of reconstructed neural tracts can indicate abnormalities such as tearing, narrowing, or discontinuations,
Sung Ho Jang, You Sung Seo
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Localized Axolemma Deformations Suggest Mechanoporation as Axonal Injury Trigger
Frontiers in Neurology, 2020 Traumatic brain injuries are a leading cause of morbidity and mortality worldwide. With almost 50% of traumatic brain injuries being related to axonal damage, understanding the nature of cellular level impairment is crucial.
Annaclaudia Montanino +3 more
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A possible role for integrin signaling in diffuse axonal injury. [PDF]
PLoS ONE, 2011 Over the past decade, investigators have attempted to establish the pathophysiological mechanisms by which non-penetrating injuries damage the brain. Several studies have implicated either membrane poration or ion channel dysfunction pursuant to neuronal
Matthew A Hemphill +7 more
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