Results 1 to 10 of about 100,199 (116)
Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury [PDF]
Annals of Clinical and Translational NeurologyDiffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical ...
Karinn Sytsma +9 more
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Inhibition of the Sp1/CTR1 axis attenuates cuproptosis and alleviates axonal injury following intracerebral hemorrhage [PDF]
Frontiers in Molecular BiosciencesIntracerebral hemorrhage (ICH) causes severe neurological deficits, and secondary neuronal injury is a major barrier to recovery. Cuproptosis, a copper-dependent form of regulated cell death, has been linked to metabolic stress, but its role in axonal ...
Ke Zhang +9 more
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Axonal injury, sleep disturbances, and memory following traumatic brain injury [PDF]
Annals of Clinical and Translational NeurologyObjectives Traumatic brain injury (TBI) is associated with sleep deficits, but it is not clear why some report sleep disturbances and others do not. The objective of this study was to assess the associations between axonal injury, sleep, and memory in ...
Emma M. Tinney +7 more
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Neural Regeneration Research, 2022 The main advantage of diffusion tensor tractography is that it allows the entire neural tract to be evaluated. In addition, configurational analysis of reconstructed neural tracts can indicate abnormalities such as tearing, narrowing, or discontinuations,
Sung Ho Jang, You Sung Seo
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Unraveling axonal mechanisms of traumatic brain injury
Acta Neuropathologica Communications, 2022 Axonal swellings (AS) are one of the neuropathological hallmark of axonal injury in several disorders from trauma to neurodegeneration. Current evidence proposes a role of perturbed Ca2+ homeostasis in AS formation, involving impaired axonal transport ...
Victorio M. Pozo Devoto +10 more
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Identifying the Phenotypes of Diffuse Axonal Injury Following Traumatic Brain Injury
Brain Sciences, 2023 Diffuse axonal injury (DAI) is a significant feature of traumatic brain injury (TBI) across all injury severities and is driven by the primary mechanical insult and secondary biochemical injury phases.
Justin L. Krieg +3 more
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The Mechanisms of Peripheral Nerve Preconditioning Injury on Promoting Axonal Regeneration
Neural Plasticity, 2021 Two major factors contribute to the failure of axonal regrowth in the central nervous system (CNS), namely, the neuronal intrinsic regenerative capacity and the extrinsic local inhibitory microenvironments.
Xiaoyan Yang +4 more
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Protein post-translational modifications after spinal cord injury
Neural Regeneration Research, 2021 Deficits in intrinsic neuronal capacities in the spinal cord, a lack of growth support, and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating consequences.
Shuang Zhu +9 more
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The Journal of Clinical Investigation, 2022 In Guillain-Barré syndrome (GBS), both axonal and demyelinating variants can be mediated by complement-fixing anti–GM1 ganglioside autoantibodies that target peripheral nerve axonal and Schwann cell (SC) membranes, respectively. Critically, the extent of
Rhona McGonigal +8 more
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Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. [PDF]
PLoS Genetics, 2019 Following injury, axons of the peripheral nervous system have retained the capacity for regeneration. While it is well established that injury signals require molecular motors for their transport from the injury site to the nucleus, whether kinesin and ...
Melissa Ducommun Priest +3 more
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