Results 21 to 30 of about 1,099,148 (284)

Axonal injury in reverse

Nature Medicine, 2011
Axonal damage causes neurological defects in multiple sclerosis. In vivo imaging in mouse models of multiple sclerosis now shows a reversible and sequential process of focal axonal degeneration (FAD) (pages 495–499 ), suggesting the use of neuroregenerative as well as neuroprotective drugs as ...
Craner, Matt J, Fugger, Lars
openaire   +2 more sources

Behavioral Deficits and Axonal Injury Persistence after Rotational Head Injury Are Direction Dependent [PDF]

, 2013
Pigs continue to grow in importance as a tool in neuroscience. However, behavioral tests that have been validated in the rodent model do not translate well to pigs because of their very different responses to behavioral stimuli.
Propert, Kathleen J, Sullivan, Sarah, Friess, Stuart H, Smith, Colin; id_orcid, Margulies, Susan S, Rapp, Paul E, Ralston, Jill   +6 more
core   +1 more source

Axonal Injury in Cerebral Malaria [PDF]

The American Journal of Pathology, 2002
Impairment of consciousness and other signs of cerebral dysfunction are common complications of severe Plasmodium falciparum malaria. Although the majority of patients make a complete recovery a significant minority, particularly children, have sequelae. The pathological process by which P.
Medana, I, Day, N, Hien, T, Mai, N, Bethell, D, Phu, N, Farrar, J, Esiri, M, White, N, Turner, G   +9 more
openaire   +3 more sources

White matter damage and cognitive impairment after traumatic brain injury [PDF]

, 2010
White matter disruption is an important determinant of cognitive impairment after brain injury, but conventional neuroimaging underestimates its extent.
Powell, Jane Hilary, Leech, R, K. M. Kinnunen, Counsell, Serena Jane; id_orcid, Bonnelle, V., Sharp, D. J., Kinnunen, K. M., Hawkins, Peter Charlie; id_orcid, Patel, Maneesh Chandrakant, Patel, MC, M. C. Patel, Sharp, David James, Greenwood, Richard, D. J. Sharp, Hawkins, PC, Leech, R., Patel, M. C., Powell, Jane H., Greenwood, R, J. H. Powell, Counsell, S. J., Sharp, DJ, P. C. Hawkins, Counsell, SJ, Powell, JH, R. Greenwood, Kinnunen, KM, R. Leech, Bonnelle, Valerie, Leech, Robert, V. Bonnelle, Kinnunen, Kirsi Maria, Hawkins, R. C., S. J. Counsell   +33 more
core   +1 more source

Intracellular calcium release through IP3R or RyR contributes to secondary axonal degeneration

Neurobiology of Disease, 2017
Severed CNS axons often retract or dieback away from the injury site and fail to regenerate. The precise mechanisms underlying acute axonal dieback and secondary axonal degeneration remain poorly understood.
Ben C. Orem, Nicolas Pelisch, Joshua Williams, Jacqueline M. Nally, David P. Stirling   +4 more
doaj   +1 more source

Clinical Outcomes of Diffuse Axonal Injury According to Radiological Grade [PDF]

Journal of Trauma and Injury, 2018
Purpose Patients with diffuse axonal injury experience various disabilities and have a high cost of treatment. Recent researches have revealed the underlying mechanism and pathogenesis of diffuse axonal injury.
Hak-Jae Lee, Hyun-Woo Sun, Jae-Seok Lee, Nak-Joon Choi, Yoon-Joong Jung, Suk-Kyung Hong   +5 more
doaj   +1 more source

Folic Acid Enhances Early Functional Recovery in a Piglet Model of Pediatric Head Injury [PDF]

, 2010
For stroke and spinal cord injury, folic acid supplementation has been shown to enhance neurodevelopment and to provide neuroprotection. We hypothesized that folic acid would reduce brain injury and improve neurological outcome in a neonatal piglet model
Jill Ralston, Friess, Stuart, Susan S. Margulies, Naim, Maryam Y., Colin Smith, Helfaer, Mark A., Maryam Y. Naim, Karen Ryall, Ryall, Karen, Margulies, Susan S., Smith, Colin; id_orcid, Mark A. Helfaer, Ralston, Jill, Stuart Friess   +13 more
core   +1 more source

Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement

Scientific Reports, 2022
Blast exposure can injure brain by multiple mechanisms, and injury attributable to direct effects of the blast wave itself have been difficult to distinguish from that caused by rapid head displacement and other secondary processes. To resolve this issue,
Robin Bishop, Seok Joon Won, Karen-Amanda Irvine, Jayinee Basu, Eric S. Rome, Raymond A. Swanson   +5 more
doaj   +1 more source

Increases in Retrograde Injury Signaling Complex-Related Transcripts in Central Axons following Injury

Neural Plasticity, 2016
Axons in the peripheral nervous system respond to injury by activating retrograde injury signaling (RIS) pathways, which promote local axonal protein synthesis (LPS) and neuronal regeneration.
Gunja K. Pathak, Hannah Ornstein, Helim Aranda-Espinoza, Amy J. Karlsson, Sameer B. Shah   +4 more
doaj   +1 more source

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

Neurobiology of Disease, 2012
Glaucoma is a neurodegenerative disease characterized by the apoptotic death of retinal ganglion cells (RGCs). The primary insult to RGCs in glaucoma is thought to occur to their axons as they exit the eye in the optic nerve head.
Kimberly A. Fernandes, Jeffrey M. Harder, Laura B. Fornarola, Robert S. Freeman, Abbot F. Clark, Iok-Hou Pang, Simon W.M. John, Richard T. Libby   +7 more
doaj   +1 more source