Results 41 to 50 of about 1,229,293 (285)

Rapid and Reversible Development of Axonal Varicosities: A New Form of Neural Plasticity

Frontiers in Molecular Neuroscience, 2021
Axonal varicosities are enlarged, heterogeneous structures along axonal shafts, profoundly affecting axonal conduction and synaptic transmission. They represent a key pathological feature believed to develop via slow accumulation of axonal damage that ...
Chen Gu
doaj   +1 more source

The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats

Neurobiology of Disease, 2004
Experimental models of traumatic brain injury have been developed to replicate selected aspects of human head injury, such as contusion, concussion, and/or diffuse axonal injury.
Ibolja Cernak, Robert Vink, David N. Zapple, Maria I. Cruz, Farid Ahmed, Taeun Chang, Stanley T. Fricke, Alan I. Faden   +7 more
doaj   +1 more source

A Precise, Controllable in vitro Model for Diffuse Axonal Injury Through Uniaxial Stretch Injury

Frontiers in Neuroscience, 2019
Regarding the determination of the biomechanical parameters in a reliable in vitro cell model for diffuse axonal injury (DAI), our study aimed to demonstrate connections between those parameters and secondary axotomy through examination of morphological ...
Yu Li, Yu Li, Chaoxi Li, Chao Gan, Kai Zhao, Jianbin Chen, Jinning Song, Ting Lei   +7 more
doaj   +1 more source

Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive brain atrophy has now been widely observed in the chronic stages of moderate–severe traumatic brain injury (msTBI), but there is only coarse information regarding its prevalence and magnitude, and whether rate of atrophy accelerates or attenuates across time. We examined these questions in a Canadian inception cohort from
Robin E. A. Green, Brenda Colella, Alana Changoor, David J. Mikulis, Adrienne Li, Kadeen Johns, Georges A. Monette   +6 more
wiley   +1 more source

MRI evidence for altered venous drainage and intracranial compliance in mild traumatic brain injury. [PDF]

, 2013
To compare venous drainage patterns and associated intracranial hydrodynamics between subjects who experienced mild traumatic brain injury (mTBI) and age- and gender-matched controls.
Straube, Andreas, Alperin, N., Heinen, Florian, Florian Heinen, Ertl-Wagner, Birgit, Ruediger P Laubender, Noam Alperin, Alperin, Noam, Inga Koerte, Lee, S., Andreas Straube, Pomschar, A., Laubender, Ruediger P, Birgit Ertl-Wagner, Pomschar, Andreas, Laubender, Rüdiger P., Andreas Pomschar, Koerte, Inga, Koerte, I., Straube, A., Lee, Sang, Sang Lee, Laubender, Ruediger P., Ertl-Wagner Birgit, Pomschar Andreas, Lee Sang, Koerte Inga, Straube Andreas, Laubender Ruediger P., Heinen Florian, Alperin Noam   +30 more
core   +2 more sources

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Investigating neurodegeneration after traumatic brain injury: a longitudinal study of axonal injury [PDF]

, 2021
Traumatic brain injury (TBI) is associated with neurodegeneration and dementia, with Alzheimer’s disease (AD) reported to be more prevalent post-injury.
Graham, Neil
core   +1 more source

Efficacy of Fampridine on Refractory Optic Neuritis in Neuromyelitis Optica Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorders (NMOSD) usually occur with acute refractory optic neuritis (ON). However, there is a lack of efficacious treatments to improve recovery. Since fampridine has been found to improve the prognosis of multiple sclerosis (MS) and MS‐related ON, it is necessary to explore the efficacy of fampridine ...
Hongxuan Wang, Wanru Chen, Xiangpen Li, Hengjian Lu, Chenguang Li, Xiaoni Zhang, Lulu Bu, Xiaoyu Xu, Qingyu Shen, Ying Peng   +9 more
wiley   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

A cognitive profile of South African children with traumatic brain injury [PDF]

, 2010
Includes bibliographical references (leaves 86-105).Research conducted on pediatric populations have shown that an event such as a traumatic brain injury (TBI) experienced in childhood can lead to persistent neuropsychological deficits months, even years
Malgas, Nancy
core   +1 more source