Results 151 to 160 of about 3,002 (191)
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Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 19863-N-([18F]fluoroalkyl)spiperone derivatives (2,3) can be prepared by N-alkylation of spiperone (1) with fluoroalkyl halides. The fluoroalkylating species 2-[18F]fluoroethyl bromide (7), 3-[18F]fluoropropyl bromide (8) and 4-[18F]fluorobutyl bromide (9) were prepared by [18F]fluoride ion displacement of the corresponding trifluoromethanesulfonates ...
D Y, Chi +4 more
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The effect of cholecystokinin octapeptide on rat striatal 3H spiperone binding
Biochemical Pharmacology, 1985In the rat striatum sulphated CCK8 has no significant effect on equilibrium binding of 3H-spiperone but has a considerable, although transient, effect under non-equilibrium conditions. Under non-equilibrium conditions (during the association phase of ligand binding) and at high ligand concentrations (1 nM), CCK8 displaces specific binding and at low ...
C, O'Shaughnessy +2 more
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Effect of mazindol on brain dopamine turnover in spiperone-treated rats
Journal of Neural Transmission, 1979Mazindol, an anorexic drug, caused a large increase in brain 3, 4-dihydroxyphenylacetic acid (DOPAC) concentration in spiperone-pretreated rats. The increase was dose-related over a 1--10 mg/kg dose range of mazindol and was maximum within 1 hour after maxzindol injection into rats pretreated 1 hour previously with spiperone.
R W, Fuller, H D, Snoddy
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The effects of exercise training on [3H]-spiperone binding in rat striatum
Pharmacology Biochemistry and Behavior, 1984Thirty male Sprague-Dawley rats 100 days of age were divided into three groups: interval trained, endurance trained, and pair-weighted controls. Both trained groups ran up to one hour per day, 6 days per week for 12 weeks. The interval trained group ran up to 20 repeat intervals at 54 meters per minute for 30 seconds, while the endurance trained group ...
P E, Gilliam +5 more
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Comparison of 3H-spiperone binding in caudate nuclei of rabbits and rats
Pharmacology Biochemistry and Behavior, 19873H-Spiperone binding and inhibition by competing ligands were studied in caudate nucleus homogenates from Sprague-Dawley rats and New Zealand albino rabbits. 3H-Spiperone binding sites were very similar in the two species and had pharmacological profiles characteristic of D2-dopamine receptors, in accordance with previous reports.
L L, Hernandez, D A, Powell
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Solubilization of 3H-spiperone binding sites from rat brain
Life Sciences, 1978Abstract Preliminary evidence indicates that specific 3 H-spiperone binding sites from rat striatum and frontal cortex may be obtained in a solubilized form using digitonin. The ligand-macromolecular complex was separated from the free ligand by means of a gel-filtration procedure.
H, Gorissen, P M, Laduron
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Binding of3H-spiperone in the mouse brain after intraperitoneal injection
Bulletin of Experimental Biology and Medicine, 1985In experiments on mice 3H-spiperone binding after intraperitoneal injection was studied. The binding of 3H-spiperone was saturable in the frontal cortex and subcortical structures, whereas in the cerebellum, the amount of radioactivity increased in a linear manner and was referred to as nonspecific binding.
A M, Zharkovskiĭ +2 more
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[3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders
1990There is ample evidence indicating that the central nervous system and the immune system are functionally linked. The exact mode of neural — immune interaction is still not certain, however the presence of specific neurotransmitter receptors on these cells appears to be important in mediating an intracellular event which could then lead to alterations ...
B. Bondy, B. Peuker, M. Ackenheil
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Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis
Annals of Neurology, 1986AbstractLevels of dopamine and serotonin, and of their precursors and metabolites, were measured in the nucleus basalis of Meynert (nbM) of patients with Alzheimer's disease and control patients. [3H]Spiperone binding to membrane homogenates of the nbM, indicative of both dopaminergic and serotonergic receptors, was also measured. The nbM from patients
D L, Sparks +2 more
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3H-spiperone binding capacity in mononuclear cells: A family study
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19931. A family study was carried out using a putative biological vulnerability trait in families of schizophrenics and schizoaffective indexprobands to investigate, if the clinical phenotype and a biological marker for schizophrenia are cosegregating within families. 2.
B, Bondy +7 more
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