Results 251 to 260 of about 559,591 (386)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Synthetic nano-kirigami with high deformability for reconfigurable information displays. [PDF]

Nat Commun
Hong X, Sun H, Meng F, Niu M, Zhang Y, Zhang X, Li C, Chen Y, Jiao Q, Liang Q, Dong W, Wang Y, Lin H, Huang X, Jia B, Li J.   +15 more
europepmc   +1 more source

Internal structure of spiral arms traced with [CII]: Unraveling the WIM, HI, and molecular emission lanes [PDF]

, 2015
T. Velusamy, W. D. Langer, P. F. Goldsmith, J. L. Pineda   +3 more
openalex   +1 more source

Bio‐Inspired Micro‐Fin‐Assisted Multi‐Modal Vascular Intervention

Advanced Science, EarlyView.
A magnetic guidewire with a micro‐fin–integrated tip is introduced for multimodal cardiovascular navigation. The micro‐fins exploit fluid drag to augment magnetic torque, enabling bifurcation traversal at 15 mT, tolerating 45° misalignment, bidirectional crawling, and buckle self‐correction.
Xu Liu, Qiang Luo, Zhuoqun Cao, Hongde Li, Xi Chen, Hong Wang, Mao Chen, Ziyu Ren, Wenqi Hu   +8 more
wiley   +1 more source

Dynamical effects of the spiral arms on the velocity distribution of disc stars [PDF]

, 2017
Kohei Hattori, Naoteru Gouda, Taihei Yano, Nobuyuki Sakai, Hiromichi Tagawa   +4 more
openalex   +1 more source

DNA‐Guided Robust Single‐Protein Electronic Readout

Advanced Science, EarlyView.
Electronic measurements of single proteins can reveal fundamental insights into their structure, dynamics, and interactions, but reproducibility is severely limited by the intrinsic structural heterogeneity of proteins combined with uncontrolled molecular orientation and electrode contact geometries.
Ziyi Ju, Zhaoxiang Deng, Yueqi Li, Jinghong Li   +3 more
wiley   +1 more source

Silver nanospirals via autoaccelerated oriented assembly. [PDF]

Commun Chem
Mravljak R, Kuljanin A, Skalar T, Genorio B, Marinšek M, Podgornik A.   +5 more
europepmc   +1 more source

Curvy Surface Reconstruction

Advanced Science, EarlyView.
This review introduces the concept of “general curvy surface reconstruction,” which incorporates both geometric and physical dimensions, representing an upgrade over conventional geometric reconstruction that focuses solely on spatial relationships. Particular emphasis is placed on the emerging opportunities enabled by advanced measurement techniques ...
Chen Shang, Haoyu Qi, Zhigang Wang, Keyu Meng, Zeye Liu, Zeng Meng, Yu Yang, Jianjun Wang, Shan Jiang   +8 more
wiley   +1 more source

The short-term effects of spiral stabilization on human posture correction. [PDF]

BMC Sports Sci Med Rehabil
Song X, Li Z, Song Y, Shah MAA, Zhang XH, Li C, Gilmore C, Jiang WB, Sui HJ.   +8 more
europepmc   +1 more source

An Elastocaloric Polymer with Ultra‐High Solid‐State Cooling via Defect Engineering

Advanced Science, EarlyView.
This work reports a defect‐engineering strategy that enables a record‐high adiabatic temperature change of up to 8.14 ± 1.76 °C in elastomers at an elevated temperature above 65 °C. Combined experimental and theoretical efforts reveal that increasing dangling‐chain defects nonmonotonically impacts the elastocaloric cooling performance of polymers due ...
Zhaohan Yu, Duo Xu, Zumrat Usmanova, Chuwei Ye, Aditya Swarnkar, Emma Scott, Sizhe Huang, Siyuan Rao, Xinyue Liu, Svetlana V. Boriskina, Ruobing Bai, Shaoting Lin   +11 more
wiley   +1 more source