Results 31 to 40 of about 8,038 (262)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The discovery of the spiral arms of the Milky Way [PDF]

Symposium - International Astronomical Union, 1985
Attempts in the 1930s and 1940s to determine the spiral structure of the Milky Way by star counting methods, essentially the continuation of the work of the Kapteyn Astronomical Laboratory, failed to reach this goal. A new foundation for the search was laid by Walter Baade in his studies of stellar populations. With the recognition that highly luminous
openaire   +1 more source

The Warp and Spiral Arms of the Milky Way [PDF]

, 2008
This is a pre-published version which is collected from arXiv link.
Levine, E.S., Blitz, Leo, Heiles, Carl, Weinberg, Martin D   +3 more
openaire   +3 more sources

A New Spiral Arm of the Galaxy: The Far 3 kpc Arm [PDF]

The Astrophysical Journal, 2008
We report the detection in CO of the far-side counterpart of the well-known expanding 3-Kpc Arm in the central region of the Galaxy. In a CO longitude-velocity map at b = 0 deg the Far 3-Kpc Arm can be followed over at least 20 deg of Galactic longitude as a faint lane at positive velocities running parallel to the Near Arm.
Dame, T. M., Thaddeus, P.
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Star Formation and Magnetic Field Amplification due to Galactic Spirals

The Astrophysical Journal
We use global MHD galaxy simulations to investigate the effects of spiral arms on the evolution of magnetic fields and star formation within a self-regulated interstellar medium.
Hector Robinson, James Wadsley, J. A. Sellwood, Ralph E. Pudritz   +3 more
doaj   +1 more source

The Distribution of Open Clusters in the Galaxy

Frontiers in Astronomy and Space Sciences, 2021
In this work we explore the new catalog of galactic open clusters that became available recently, containing 1,750 clusters that have been re-analyzed using the Gaia DR2 catalog to determine the stellar memberships.
Hektor Monteiro, Douglas A. Barros, Wilton S. Dias, Jacques R. D. Lépine   +3 more
doaj   +1 more source

Spiral-arm instability: giant clump formation via fragmentation of a galactic spiral arm [PDF]

Monthly Notices of the Royal Astronomical Society, 2017
Fragmentation of a spiral arm is thought to drive the formation of giant clumps in galaxies. Using linear perturbation analysis for self-gravitating spiral arms, we derive an instability parameter and define the conditions for clump formation. We extend our analysis to multi-component systems that consist of gas and stars in an external potential.
Inoue, Shigeki, Yoshida, Naoki
openaire   +2 more sources

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source