Results 241 to 250 of about 13,039 (280)

Unraveling the mysteries of spiral artery remodeling

Placenta, 2023
Spiral artery remodeling is the process by which the uterine vessels become large bore low resistance conduits, allowing delivery of high volumes of maternal blood to the placenta to nourish the developing fetus. Failure of this process is associated with the pathophysiology of most of the major obstetric complications, including late miscarriage ...
Lindong Zhang, Jing Liu, Xiaoqian Feng, Gendie E. Lash   +3 more
openaire   +2 more sources

Role of osteopontin (OPN) in uterine spiral artery remodeling

Placenta, 2022
Uterine spiral artery (SpA) remodeling is critical for a successful pregnancy. The deficiency of SpA remodeling seriously affects the blood perfusion of the placenta, impacting the nutritional supply to the fetus and therefore fetal growth and development, which is one of the pathological causes of pregnancy related diseases.
Yue Pan, Miaojuan Chen, Gendie E. Lash
openaire   +2 more sources

Spiral artery remodeling and maternal cardiovascular risk

Journal of Hypertension, 2016
Women with a history of placental bed disorders, including preeclampsia and intrauterine growth restriction have an increased long-term risk of cardiovascular disease (CVD). Further, similarities exist between atherosclerosis and abnormalities observed in placental bed spiral arteries in pregnancies affected by preeclampsia and intrauterine growth ...
Veerbeek, Jan H W, Brouwers, Laura, Koster, Maria P H, Koenen, Steven V., van Vliet, Elvira O G, Nikkels, Peter G J, Franx, Arie, van Rijn, Bas B.   +7 more
openaire   +3 more sources

Endovascular trophoblast and spiral artery remodeling

Molecular and Cellular Endocrinology, 2020
Spiral artery remodeling, which is indispensable for successful pregnancy, is accomplished by endovascular trophoblasts that move upstream along the arterial wall, replace the endothelium, and disrupt the muscular lining. This review outlines the possible factors that could regulate endovascular trophoblast differentiation and invasion.
openaire   +2 more sources

Decidual spiral artery remodelling begins before cellular interaction with cytotrophoblasts

Placenta, 1998
Endometrial arteries undergo structural alterations during pregnancy to increase blood flow to the intervillous space. It is hypothesized that physiologic change in decidual arteries is similar to vascular remodelling seen in other organs. Histologic features of spiral arteries in secretory endometrial biopsies were compared blindly to decidual ...
C M, Craven, T, Morgan, K, Ward
openaire   +2 more sources

Ex vivo endothelin dependent contraction of the remodeled rat spiral artery

Placenta, 2014
Similarities of the rat to the human placenta make rat pregnancy models relevant to the study of human gestational diseases. Understanding of species differences is necessary to extrapolate from animal models to humans. We observed alpha-smooth muscle actin (αSMA) expression in rat endovascular trophoblasts (EVasT) and investigated the spatial and ...
I, Ariel, G, Skarzinski, T, Kossovsky, V, Belzer, D, Knigin, M, Khamaisi, Z, Abassi, M, Bursztyn   +7 more
openaire   +2 more sources

Ephrin-B2 mediates trophoblast-dependent maternal spiral artery remodeling in first trimester

Placenta, 2015
Maternal spiral artery remodeling after embryo implantation is a crucial process for successful pregnancy and rely on well-controlled trophoblast functions. Ephrin-B2 is found to be of great importance in various cell functions in both benign human tissue and tumors. However, its role in the regulation of trophoblast remains unknown.
Q. Luo, X. Liu, Y. Zheng, Y. Zhao, J. Zhu, L. Zou   +5 more
openaire   +2 more sources

Dysregulated Mitochondrial Calcium Causes Spiral Artery Remodeling Failure in Preeclampsia

Hypertension
BACKGROUND: Calcium deficiency in women is strongly linked to an increased risk of developing preeclampsia. Mitochondrial calcium ([Ca 2+ ] m ) homeostasis is essential to regulate vascular smooth muscle cell (VSMC) function. However, the role of [Ca
Xiyuan Lu, Yifan Wang, Na Geng, Zhiguo Zou, Xueqing Feng, Yuehong Wang, Zhice Xu, Ning Zhang, Jun Pu   +8 more
openaire   +2 more sources

Trophoblast Invasion: Remodelling of Spiral Arteries and Beyond

2018
Despite massive scientific and clinical efforts, the etiology of preeclampsia remains a mystery. Quite a variety of different hypotheses has been developed and this is ongoing, but none of them has been able to explain the symptoms of the different preeclampsia subtypes satisfactorily.
openaire   +1 more source

Deep trophoblast invasion and spiral artery remodelling in the placental bed of the chimpanzee

Placenta, 2011
Deep trophoblast invasion is usually considered to be a unique feature of human placentation as compared to other primates. Because of the occasional occurrence of preeclampsia in great apes, which in the human is associated with impaired deep invasion, this uniqueness may be questioned. The availability of two well-documented pregnant chimpanzee uteri
Pijnenborg, R, Vercruysse, L, Carter, Anthony Michael   +2 more
openaire   +3 more sources