Results 61 to 70 of about 13,039 (280)

Porphyromonas gingivalis strain-dependent inhibition of uterine spiral artery remodeling in the pregnant rat. [PDF]

Biol Reprod, 2018
Porphyromonas gingivalis (Pg) is an important periodontal pathogen that is also implicated in pregnancy complications involving defective deep placentation (DDP). We hypothesized that Pg invasion of the placental bed promotes DDP. Pregnant rats were intravenously inoculated with sterile vehicle, Pg strain W83, or A7436 at gestation day (GD) 14 (acute ...
Phillips P, Brown MB, Progulske-Fox A, Wu XJ, Reyes L.   +4 more
europepmc   +4 more sources

A possible new approach in the prediction of late gestational hypertension: The role of the fetal aortic intima-media thickness [PDF]

, 2017
The aim was to determine the predictive role of combined screening for late-onset gestational hypertension by fetal ultrasound measurements, third trimester uterine arteries (UtAs) Doppler imaging, and maternal history.
Camerin, Martina, Cosmi, Erich, Grisan, Enrico, Londero, Ambrogio P., Visentin, Silvia   +4 more
core   +1 more source

4307 Role of Pre-pregnancy Uterine Natural Killer Cells in Human Embryo Implantation

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Human placentation requires complex coordination between maternal and fetal cell types but remains incompletely understood. We hypothesize that uterine natural killer (uNK) cells, an immune cell type that increases in abundance during ...
Jessica Kanter, Sneha Mani, Scott Gordon, Monica Mainigi   +3 more
doaj   +1 more source

Manipulating CD4+ T Cell Pathways to Prevent Preeclampsia

Frontiers in Bioengineering and Biotechnology, 2022
Preeclampsia (PreE) is a placental disorder characterized by hypertension (HTN), proteinuria, and oxidative stress. Individuals with PreE and their children are at an increased risk of serious short- and long-term complications, such as cardiovascular ...
Eileen J. Murray, Serena B. Gumusoglu, Serena B. Gumusoglu, Donna A. Santillan, Donna A. Santillan, Mark K. Santillan, Mark K. Santillan, Mark K. Santillan, Mark K. Santillan, Mark K. Santillan   +9 more
doaj   +1 more source

Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]

, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine, AC Epstein, AM Carter, AM Zafari, Anne E Chambers, AP MacKay, BJ Hawkins, C Moser, C Peyssonnaux, CW Redman, D Berg, D Gerald, DS Hoffmann, DS Tannetta, EL Bell, EL Pagé, FX Yi, GL Semenza, H Pelicano, Harpal Randeva, I Thaler, J Golab, J Sugawara, JA Martin, K Kanasaki, L Duley, L Wood, M Geiszt, M Ushio-Fukai, M Wang, N Kanayama, NS Chandel, P Huang, PH Maxwell, R Dworakowski, R Pijnenborg, RD Martin, RK Bruick, RW Redline, S Banerjee, S Lamond, S Melov, S Muzaffar, S Nemoto, SL Adamson, Subhasis Banerjee, T Cramer, T Torbergsen, Y Liu, Y Pan, Y Wang, YA Suh   +51 more
core   +4 more sources

Insights into Early-Pregnancy Mechanisms: Mast Cells and Chymase CMA1 Shape the Phenotype and Modulate the Functionality of Human Trophoblast Cells, Vascular Smooth-Muscle Cells and Endothelial Cells

Cells, 2022
Spiral-artery (SA) remodeling is a fundamental process during pregnancy that involves the action of cells of the initial vessel, such as vascular smooth-muscle cells (VSMCs) and endothelial cells, but also maternal immune cells and fetal extravillous ...
Ningjuan Zhang, Anne Schumacher, Beate Fink, Mario Bauer, Ana Claudia Zenclussen, Nicole Meyer   +5 more
doaj   +1 more source

Uterine natural killer cell heterogeneity: Lessons from mouse models [PDF]

, 2020
Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes.
Sojka, Dorothy K
core   +1 more source

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]

, 2014
STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
A. E. Wallace, A. P. Johnstone, Athanassiades, Cartwright, Choy, Desai, Engert, Fraser, Furuya, G. S. Whitley, Hanna, J. E. Cartwright, Karamouzis, Kim, King, King, Koga, Meekins, Melchiorre, Moroianu, Nasu, Pijnenborg, Pijnenborg, Pollheimer, Prefumo, Prefumo, R. Fraser, Rehn, S. Gurung, S. S. Goulwara, Santoni, Treiber-Held, van der Harten, Verma, Wei, Zhou   +35 more
core   +2 more sources

Decidual natural killer cells regulate vessel stability: implications for impaired spiral artery remodelling [PDF]

Journal of Reproductive Immunology, 2015
Decidual NK (dNK) cells are present during uterine spiral artery remodelling, an event that is crucial for successful placentation and the provision of an adequate blood supply to the developing fetus. Spiral artery remodelling is impaired in the pregnancy complication pre-eclampsia.
Fraser, Rupsha, Whitley, Guy St J, Thilaganathan, Baskaran, Cartwright, Judith E   +3 more
openaire   +3 more sources

Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance [PDF]

, 2012
During human pregnancy, natural killer (NK) cells accumulate in the maternal decidua, but their specific roles remain to be determined. Decidual NK (dNK) cells are present during trophoblast invasion and uterine spiral artery remodelling.
Cartwright, JE, Fraser, R, Host, AJ, Johnstone, AP, Sebire, NJ, Thilaganathan, B, Whitley, GS   +6 more
core   +1 more source