Results 191 to 200 of about 1,712,028 (279)

Synthesis of spiro cyclopentenone-pyran and spiro dihydropyran compounds

, 2013
121
openaire   +2 more sources

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

PVA-Borax Hydrogels Loaded with Mono- and Bis-Spiro-Dioxy-Biphenyl-Cyclotriphosphazenes: Fabrication, Physicochemical Properties, and Release Kinetics. [PDF]

Molecules
Topel SD.
europepmc   +1 more source

<i>Pongamia pinnata</i> (L.) Pierre leaf extract: <i>in vitro</i>, <i>in vivo</i>, and <i>in silico</i> approaches to combat the waterborne bacterial pathogens associated with diarrheal conditions. [PDF]

Front Cell Infect Microbiol
Kumar A, Laldingliani TBC, Kumar R, Thangjam NM, Vuite R, Sahu SK, Rawat R, Behl T, Eyupoglu V.   +8 more
europepmc   +1 more source

Eliminating Residue-Induced Degradation: A Volatile Dopant Strategy for High Performance Perovskite Photovoltaics. [PDF]

Small
Zhao J, Li Z, Dong J, Cao J, Wang Y, Chang J, Liu B, Hu X, Chu Y, Yan W, Zhong C, Xie J, Chen S, Wang A, Huang W, Qin T.   +15 more
europepmc   +1 more source

Deprotonation and Alkylation of Weakly Acidic C(sp3)─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert‐Butoxide

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge, Brandon White, Han Yao, Travis Dudding, Stephen G. Newman   +4 more
wiley   +2 more sources

Recent developments in the chemistry of γ-, δ- and ε-sultones. [PDF]

RSC Adv
Dawood KM, Tawfeek HN, Abbas AA.
europepmc   +1 more source

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Limiting Trial‐and‐Error: Linker‐Based 2D Descriptor Analysis to Support Very Early Proteolysis‐Targeting Chimeras Design

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Can simple linker descriptors guide PROTAC design? Analysis of matched CRBN‐ and VHL‐recruiting degraders shows that basic 2D linker properties may capture trends linked to degradation efficiency, in vitro ADME and physicochemical properties. A practical approach to reduce trial‐and‐error in early targeted protein degradation programs. Targeted protein
Giulia Apprato, Serena Traversa, Giulia Caron, Giuseppe Ermondi   +3 more
wiley   +1 more source

Efficient and metal catalyst-free approach towards highly-substituted N-sulfonylpiperidine-/mono-spiro-1,2,4,5-tetraoxanes for potential applications in chemotherapy. [PDF]

Sci Rep
Tiwari MK, Kucinska M, Zgoła-Grześkowiak A, Grellier P, Murias M, Marczak Ł, Popenda L, Goslinski T.   +7 more
europepmc   +1 more source