Results 1 to 10 of about 4,245 (112)
Isatin-mediated inhibition of the PI3K/AKT/EMT signaling axis confers antitumor efficacy in Ehrlich solid carcinoma-bearing mice [PDF]
BMC CancerDespite advances, detailed insight into cancer’s biological mechanisms remains needed. Isatin, an indole-1 H-2,3-dione, is an attractive agent for new drug discovery.
Heba Effat +4 more
doaj +2 more sources
Effect of Long-Term Isatin Administration on Daily Physical Activity and Cardiac Performance in Female Rats [PDF]
Eurasian Journal of MedicineBackground: Isatin, an endogenous indole found in the brain and peripheral tissues, has a wide spectrum of physiological and pharmacological effects. This study aims to disclose the impact of long-term isatin administration on daily voluntary running ...
Selma Arzu Vardar +7 more
doaj +2 more sources
Pharmaceuticals, 2022 Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by ...
Shefali Chowdhary +2 more
exaly +3 more sources
Simple and Efficient Microwave Assisted N-Alkylation of Isatin
Molecules, 2008 We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried outunder different conditions, always employing methodologies compatible with MW ...
MarÃÂa Mercedes Blanco +4 more
exaly +3 more sources
Synthesis and structural elucidation of a novel bis-spirooxindole from isatin and ethylenediamine [PDF]
Beilstein Journal of Organic ChemistryThe reactivity of isatin toward ethylenediamine displays an unexpected stoichiometric divergence, affording either the anticipated diiminoisatin or a previously unreported pentacyclic bis-spirooxindole.
Irene Moreno-Gutiérrez +7 more
doaj +2 more sources
Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin
Frontiers in Behavioral Neuroscience, 2022 Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the ...
Alexei Medvedev, Olga Buneeva
doaj +1 more source
Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself,
May Mohammed Jawad Al-Mudhafar +2 more
doaj +1 more source
Synthesis of Isatin and its derivatives containing heterocyclic compounds
Journal of the Turkish Chemical Society, Section A: Chemistry, 2021 Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach
Pratibha MİSHRA +4 more
doaj +1 more source
The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7 [PDF]
Hemijska Industrija, 2016 The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied.
Ćirić Jovan T. +5 more
doaj +1 more source
Scientific Reports, 2021 The use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components.
Maryam Zarghami Dehaghani +10 more
doaj +1 more source