Isatin-mediated inhibition of the PI3K/AKT/EMT signaling axis confers antitumor efficacy in Ehrlich solid carcinoma-bearing mice [PDF]
BMC CancerDespite advances, detailed insight into cancer’s biological mechanisms remains needed. Isatin, an indole-1 H-2,3-dione, is an attractive agent for new drug discovery.
Heba Effat +4 more
doaj +2 more sources
Effect of Long-Term Isatin Administration on Daily Physical Activity and Cardiac Performance in Female Rats [PDF]
Eurasian Journal of MedicineBackground: Isatin, an endogenous indole found in the brain and peripheral tissues, has a wide spectrum of physiological and pharmacological effects. This study aims to disclose the impact of long-term isatin administration on daily voluntary running ...
Selma Arzu Vardar +7 more
doaj +2 more sources
Synthesis and structural elucidation of a novel bis-spirooxindole from isatin and ethylenediamine [PDF]
Beilstein Journal of Organic ChemistryThe reactivity of isatin toward ethylenediamine displays an unexpected stoichiometric divergence, affording either the anticipated diiminoisatin or a previously unreported pentacyclic bis-spirooxindole.
Irene Moreno-Gutiérrez +7 more
doaj +2 more sources
Simple and Efficient Microwave Assisted N-Alkylation of Isatin
Molecules, 2008 We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried outunder different conditions, always employing methodologies compatible with MW ...
MarÃÂa Mercedes Blanco +4 more
exaly +3 more sources
Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin
Frontiers in Behavioral Neuroscience, 2022 Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the ...
Alexei Medvedev, Olga Buneeva
doaj +1 more source
Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself,
May Mohammed Jawad Al-Mudhafar +2 more
doaj +1 more source
Synthesis of Isatin and its derivatives containing heterocyclic compounds
Journal of the Turkish Chemical Society, Section A: Chemistry, 2021 Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach
Pratibha MİSHRA +4 more
doaj +1 more source
The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7 [PDF]
Hemijska Industrija, 2016 The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied.
Ćirić Jovan T. +5 more
doaj +1 more source
Scientific Reports, 2021 The use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components.
Maryam Zarghami Dehaghani +10 more
doaj +1 more source
Corrosion and Inhibition of Cu-Zn Alloys in Acidic Medium by Using Isatin
International Journal of Electrochemical Science, 2008 The effect of isatin on the corrosion of Cu-Zn alloys in H2SO4 and HCl solution has been studied using open circuit potential, potentiodynamic, and electrochemical impedance spectroscopy (EIS) techniques.
S.A.M. Refaey +3 more
doaj +2 more sources