The effects of isatin (indole-2, 3-dione) on pituitary adenylate cyclase-activating polypeptide-induced hyperthermia in rats [PDF]
BMC Neuroscience, 2002 Background Previous studies have demonstrated that centrally administered natriuretic peptides and pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) have hyperthermic properties.
Tóth Gábor +4 more
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Effect of Long-Term Isatin Administration on Daily Physical Activity and Cardiac Performance in Female Rats [PDF]
Eurasian Journal of MedicineBackground: Isatin, an endogenous indole found in the brain and peripheral tissues, has a wide spectrum of physiological and pharmacological effects. This study aims to disclose the impact of long-term isatin administration on daily voluntary running ...
Selma Arzu Vardar +7 more
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Enantioselective Solvent-Free Synthesis of 3-Alkyl-3-hydroxy-2-oxoindoles Catalyzed by Binam-Prolinamides [PDF]
Molecules, 2015 BINAM-prolinamides are very efficient catalyst for the synthesis of non-protected and N-benzyl isatin derivatives by using an aldol reaction between ketones and isatins under solvent-free conditions.
Abraham Bañn-Caballero +3 more
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Pharmaceuticals, 2022 Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by ...
Amandeep Arora, Vipan Kumar
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Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Rita Meleddu +2 more
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Simple and Efficient Microwave Assisted N-Alkylation of Isatin
Molecules, 2008 We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried outunder different conditions, always employing methodologies compatible with MW ...
María Sol Shmidt
exaly +3 more sources
Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin
Frontiers in Behavioral Neuroscience, 2022 Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the ...
Alexei Medvedev, Olga Buneeva
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Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself,
May Mohammed Jawad Al-Mudhafar +2 more
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Synthesis of Isatin and its derivatives containing heterocyclic compounds
Journal of the Turkish Chemical Society, Section A: Chemistry, 2021 Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach
Pratibha MİSHRA +4 more
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The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7 [PDF]
Hemijska Industrija, 2016 The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied.
Ćirić Jovan T. +5 more
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