Results 21 to 30 of about 4,322 (180)

Isatin Aldazines Synthesis using A Proton Exchanged Algerian Montmorillonite Clay as Acid Eco-friendly Catalyst

Bulletin of Chemical Reaction Engineering & Catalysis, 2019
An efficient and easy procedure is developed for the synthesis of isatin aldazines or bis-Schiff bases of isatin, catalyzed by a proton exchanged Algerian montmorillonite clay (MMT-H+) as green catalyst.
Boumadiene Benlahreche, Assya Taleb, Mokhtar B. Lahrech, Salih Hacini   +3 more
doaj   +1 more source

Design, synthesis, docking, and antidepressant activity evaluation of isatin derivatives bearing Schiff bases [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Depression is a prevalent psychiatric disorder. Treatment of depression is still a challenge due to the lack of response of some patients to a variety of available medications and side effects.
Azadeh Mesripour, Elham Jafari, Mohamad Reza Hajibeiki, Farshid Hassanzadeh   +3 more
doaj   +1 more source

Isatin as a simple, highly selective and sensitive colorimetric sensor for fluoride anion

Heterocyclic Communications, 2020
Herein, we report the fluoride anion sensing properties of a commercially available and inexpensive organic compound, isatin, which is found to be a highly selective and sensitive sensor.
Haider Azeem, Ahmed Mukhtiar, Faisal Muhammad, Naseer Muhammad Moazzam   +3 more
doaj   +1 more source

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Pharmaceuticals, 2022
Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as ...
Rameshwar S. Cheke, Vaishali M. Patil, Sandip D. Firke, Jaya P. Ambhore, Iqrar A. Ansari, Harun M. Patel, Sachin D. Shinde, Visweswara Rao Pasupuleti, Md Imtaiyaz Hassan, Mohd Adnan, Adel Kadri, Mejdi Snoussi   +11 more
doaj   +1 more source

Synthesis and spectroscopic analysis of Schiff Bases of Imesatin and Isatin derivatives

Journal of Applied Sciences and Environmental Management, 2016
A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported.
Olubunmi S. Oguntoye, Abdulmumeen A. Hamid, Gabriel S. Iloka, Sunday O. Bodede, Samson O. Owalude, Adedibu C. Tella   +5 more
doaj   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

Journal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay, Cansu Topkaya, Elif Kağa, Yasin Eren, Ramazan Güp   +4 more
wiley   +1 more source

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni   +9 more
doaj   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni, Maria Luisa Di Paolo, Antonio Laghezza, Giorgio Cozza, Francesco Piazzola, Laura Facci, Emma Marcolin, Elena Roggiolani, Luca Piemontese, Anna Minarini, Morena Zusso, Lisa Dalla Via, Michela Rosini   +12 more
wiley   +1 more source

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source