Results 21 to 30 of about 12,385 (205)
An update on the synthesis and reactivity of spiro-fused β-lactams [PDF]
, 2018 Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic ...
D'hooghe, Matthias, Dao Thi, Hang
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Life Sciences, 2016 There has been growing interest in the synthesis of new derivatives from isatin, found in Isatis genus. Our objectives were to characterize the antinociceptive mechanism of action of isatin, N-methyl-isatin (MI) and N-methyl-3-(2-oxopropyl)-3-hydroxy-2-oxindole (MOI).Substances (0.1-10mg/kg, p.o.) were studied in chemical (paw licking induced by ...
Thais Biondino Sardella Giorno +3 more
openaire +2 more sources
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors [PDF]
, 2016 A series of (E)-3-heteroarylidenechroman-4-ones (1a-r) was designed, synthesized and investigated in vitro for their ability to inhibit the enzymatic activity of both human monoamine oxidase (hMAO) isoforms, hMAO-A and hMAO-B.
Alcaro, Stefano +6 more
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The influence of Schiff base inclusion complexes with β-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7 [PDF]
Hemijska Industrija, 2015 A media consisting of isatin-Schiff bases and its inclusion complexes with β-cyclodextrine was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine β by Streptomyces hygroscopicus CH-7.
Ilić Slavica B. +4 more
doaj +1 more source
Design, synthesis, docking, and antidepressant activity evaluation of isatin derivatives bearing Schiff bases [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Depression is a prevalent psychiatric disorder. Treatment of depression is still a challenge due to the lack of response of some patients to a variety of available medications and side effects.
Azadeh Mesripour +3 more
doaj +1 more source
Isatin as a simple, highly selective and sensitive colorimetric sensor for fluoride anion
Heterocyclic Communications, 2020 Herein, we report the fluoride anion sensing properties of a commercially available and inexpensive organic compound, isatin, which is found to be a highly selective and sensitive sensor.
Haider Azeem +3 more
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Bulletin of Chemical Reaction Engineering & Catalysis, 2019 An efficient and easy procedure is developed for the synthesis of isatin aldazines or bis-Schiff bases of isatin, catalyzed by a proton exchanged Algerian montmorillonite clay (MMT-H+) as green catalyst.
Boumadiene Benlahreche +3 more
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Pharmaceuticals, 2022 Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as ...
Rameshwar S. Cheke +11 more
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Ruthenium catalyzed oxidative conversion of isatins to anthranilic acids: Mechanistic study [PDF]
, 2008 Oxidation of isatins (isatin, 5-methylisatin, 5-bromoisatin, and 5-nitroisatin) to their corresponding anthranilic acids was performed with sodium N-bromo-p-toluenesulfonamide or bromamine-T (BAT) as an oxidant and ruthenium trichloride (Ru(III)) as a ...
Gowda, N.M.N. +3 more
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Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship [PDF]
, 2011 To develop more potent small molecules with enhanced free radical scavenger properties, a series of N-substituted isatin derivatives was synthesized, and the cytoprotective effect on the apoptosis of PC12 cells induced by H2O2 was screened.
Gang Chen +4 more
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