Results 1 to 10 of about 1,535,483 (232)

Design, synthesis, docking, and antidepressant activity evaluation of isatin derivatives bearing Schiff bases [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Depression is a prevalent psychiatric disorder. Treatment of depression is still a challenge due to the lack of response of some patients to a variety of available medications and side effects.
Azadeh Mesripour, Elham Jafari, Mohamad Reza Hajibeiki, Farshid Hassanzadeh   +3 more
doaj   +4 more sources

Evaluation of Anti-Neuroinflammatory Activity of Isatin Derivatives in Activated Microglia [PDF]

Molecules, 2023
Neuroinflammation plays a crucial role in the progression of Alzheimer’s disease and other neurodegenerative disorders. Overactivated microglia cause neurotoxicity and prolong the inflammatory response in many neuropathologies.
Alejandro Cenalmor, José Ramón Suárez, García Álvarez, Isabel, Pascual, Elena, Isabel García-Álvarez, Cenalmor Molina, Alejandro, Cenalmor, Alejandro, Ramón Suárez, José, Elena Pascual, Pascual Vega, Elena, Rafael Correa-Rocha, Gil-Manso, Sergio, Sergio Gil-Manso, García-Álvarez, Isabel, Correa-Rocha, Rafael, Suárez Álvarez, José Ramón, Suárez, José Ramón   +16 more
core   +3 more sources

Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency [PDF]

Frontiers in Molecular Biosciences, 2021
In this review we compare and discuss results of compounds already reported as anticancer agents based on isatin-derivatives, metalated as well as non-metallated.
Raphael Enoque Ferraz de Paiva, Eduardo Guimarães Vieira, Daniel Rodrigues da Silva, Camila Anchau Wegermann, Ana Maria Costa Ferreira   +4 more
doaj   +3 more sources

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Pharmaceuticals, 2022
Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as ...
Rameshwar S. Cheke, Vaishali M. Patil, Sandip D. Firke, Jaya P. Ambhore, Iqrar A. Ansari, Harun M. Patel, Sachin D. Shinde, Visweswara Rao Pasupuleti, Md Imtaiyaz Hassan, Mohd Adnan, Adel Kadri, Mejdi Snoussi   +11 more
doaj   +4 more sources

Cytotoxicity study of some indophenines and isatin derivatives [PDF]

Bangladesh Journal of Pharmacology, 2008
Eight indophenines were synthesized for the interest of studying biological activity especially for cytotoxicity. The cytotoxicity of some indophenines and some isatin derivatives was studied by the brine shrimp lethality bioassay.
Md. Mahbubul Hoque, Md. Rabiul Islam
doaj   +3 more sources

Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives [PDF]

Journal of Chemistry, 2015
Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation.
Ayman El-Faham, Wael N. Hozzein, Mohammad A. M. Wadaan, Sherine N. Khattab, Hazem A. Ghabbour, Hoong-Kun Fun, Mohammed Rafiq Siddiqui   +6 more
doaj   +2 more sources

The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7 [PDF]

Hemijska Industrija, 2016
The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied.
Ćirić Jovan T., Konstantinović Sandra S., Ilić Slavica B., Gojgić-Cvijović Gordana, Savić Dragiša S., Veljković Vlada B.   +5 more
doaj   +4 more sources

Synthesis, Reaction and Biological Importance of Isatin Derivatives

Biomedicine and Chemical Sciences, 2022
Isatin is a heterocyclic nitrogen compound that has attracted much interest in recent years due to its diverse biological and pharmacological activities.
Mohammed G. A. Al-Khuzaie, Ahmed Jalil Al-Safi, Fahad, Mahmood M., Mahmood M. Fahad, Al-Safi, Ahmed Jalil, Al-Khuzaie, Mohammed G. A.   +5 more
core   +2 more sources

Syntheses and Pharmacological Activities of Isatin Derivatives

Journal of Drug Delivery and Therapeutics, 2019
Twenty derivatives of isatin (1H-indole-2, 3-Dione) were synthesized by the schematic route as per as scheme. These were further characterized by spectroscopic analysis.
Sachan, Neetu, Kumar, Sushil, Husain, Asif, Yadav, Mayank   +3 more
core   +2 more sources

Molecular docking and synthesis of N-alkyl-isatin-3-imino aromatic amine derivatives and their antileishmanial and cytotoxic activities

Research in Pharmaceutical Sciences
Background and purpose: Isatin derivatives have excited attention due to their biological attractions, especially, anticancer properties. Isatin analogs such as semaxanib and sunitinib were exposed to tyrosine kinase inhibitory properties.
Farshid Hassanzadeh, Seyed Hossein Hejazi, Elham Jafari, Atefeh Mohammadi fard, Hojjat Sadeghi-aliabadi   +4 more
doaj   +2 more sources