Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency [PDF]
Frontiers in Molecular Biosciences, 2021 In this review we compare and discuss results of compounds already reported as anticancer agents based on isatin-derivatives, metalated as well as non-metallated.
Raphael Enoque Ferraz de Paiva +4 more
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Design, synthesis, docking, and antidepressant activity evaluation of isatin derivatives bearing Schiff bases [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Depression is a prevalent psychiatric disorder. Treatment of depression is still a challenge due to the lack of response of some patients to a variety of available medications and side effects.
Azadeh Mesripour +3 more
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Enantioselective Solvent-Free Synthesis of 3-Alkyl-3-hydroxy-2-oxoindoles Catalyzed by Binam-Prolinamides [PDF]
Molecules, 2015 BINAM-prolinamides are very efficient catalyst for the synthesis of non-protected and N-benzyl isatin derivatives by using an aldol reaction between ketones and isatins under solvent-free conditions.
Abraham Bañn-Caballero +3 more
doaj +5 more sources
Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship [PDF]
Chemistry Central Journal, 2011 To develop more potent small molecules with enhanced free radical scavenger properties, a series of N-substituted isatin derivatives was synthesized, and the cytoprotective effect on the apoptosis of PC12 cells induced by H2O2 was screened.
Mu Shuzhen +4 more
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A Scalable and Sustainable Synthesis of Indirubin Frameworks Enabled by Deep Eutectic Solvents. [PDF]
ChemSusChemA sustainable protocol for the synthesis of indirubin in a choline chloride/urea deep eutectic solvent at 70°C under air affords the product in 70% yield without chromatography. The method is robust, scalable to pilot scale, and enables late‐stage functionalization, granting access to a wide range of indirubin derivatives. CHEM21 green metrics validate
Delvecchio B +5 more
europepmc +2 more sources
Isatin derivatives in reactions with phosphorus(III-V) compounds. [PDF]
Chem Heterocycl Compd (N Y), 2015 In this review we generalize and analyze information about reactions between isatin and three-, four-, and five-coordinate phosphorus compounds, published between 1966 and 2014.
Musin LI, Bogdanov AV, Mironov VF.
europepmc +4 more sources
Morita-Baylis-Hillman reaction of acrylamide with isatin derivatives. [PDF]
Beilstein J Org Chem, 2014 The Morita–Baylis–Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in acetonitrile.
Singh RM, Bharadwaj KC, Tiwari DK.
europepmc +5 more sources
Design and Optimization of Spiro-Isatin-Thiazolidinone Hybrids with Promising Anticancer Activity [PDF]
PharmaceuticalsBackground: Cancer remains a leading cause of morbidity and mortality worldwide, and current therapies are limited by toxicity, cost, and resistance. Inhibition of the MDM2–p53 interaction is a promising anticancer strategy, as this pathway is frequently
Dmytro Khylyuk +5 more
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Cytotoxicity study of some indophenines and isatin derivatives [PDF]
Bangladesh Journal of Pharmacology, 2008 Eight indophenines were synthesized for the interest of studying biological activity especially for cytotoxicity. The cytotoxicity of some indophenines and some isatin derivatives was studied by the brine shrimp lethality bioassay.
Md. Mahbubul Hoque, Md. Rabiul Islam
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Cytotoxicity study of dimethylisatin and its heterocyclic derivatives
Bangladesh Journal of Pharmacology, 2007 Isatin derivatives are bioactive molecules. To study the cytotoxicity and eventually the anticancer activities against cancer cell lines, a series of dimethyl-substitituted isatin derivatives (4-8) starting from isatin thiosemicarbazones (3) had been ...
Mohammad Mamun Hossain +3 more
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