Results 11 to 20 of about 7,252 (218)

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Pharmaceuticals, 2022
Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as ...
Rameshwar S. Cheke, Vaishali M. Patil, Sandip D. Firke, Jaya P. Ambhore, Iqrar A. Ansari, Harun M. Patel, Sachin D. Shinde, Visweswara Rao Pasupuleti, Md Imtaiyaz Hassan, Mohd Adnan, Adel Kadri, Mejdi Snoussi   +11 more
doaj   +3 more sources

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies. [PDF]

J Enzyme Inhib Med Chem, 2022
Elkaeed EB, Taghour MS, Mahdy HA, Eldehna WM, El-Deeb NM, Kenawy AM, A Alsfouk B, Dahab MA, Metwaly AM, Eissa IH, El-Zahabi MA.   +10 more
europepmc   +2 more sources

Solvatochromism of isatin based Schiff bases: An LSER and LFER study [PDF]

Journal of the Serbian Chemical Society, 2016
The derivatives of isatin have already been reported to show a variety of biological activities. However, there has been no report on solvatochromic effect of isatin derivatives so far, and that could be of interest to study and relate to their ...
Brkić Dominik R., Božić Aleksandra R., Nikolić Vesna D., Marinković Aleksandar D., Elshaflu Hana, Nikolić Jasmina B., Drmanić Saša Ž.   +6 more
doaj   +1 more source

Synthesis, Characterization, and Preliminary Antimicrobial Evaluation of New Schiff Bases and Mannich Bases of Isatin

Iraqi Journal of Pharmaceutical Sciences, 2023
Till now, isatin derivatives have received a lot of interest in organic and medicinal chemistry due to their significant biological and pharmacological activities.
Mustafa Mahmood Mukhlif , May Mohammed Jawad Al-Mudhafar   +1 more
doaj   +1 more source

The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7 [PDF]

Hemijska Industrija, 2016
The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied.
Ćirić Jovan T., Konstantinović Sandra S., Ilić Slavica B., Gojgić-Cvijović Gordana, Savić Dragiša S., Veljković Vlada B.   +5 more
doaj   +1 more source

Synthesis of Isatin and its derivatives containing heterocyclic compounds

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach
Pratibha MİSHRA, Arunesh MİSHRA, Anil Kumar BAHE, Atish ROY, Ratnesh DAS   +4 more
doaj   +1 more source

Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives [PDF]

, 2010
A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by
Ajani, Olayinka O.
core   +1 more source

Synthesis and evaluation of anticonvulsant activity of (Z)-4-(2-oxoindolin-3-ylideneamino)-N-phenylbenzamide derivatives in mice

Research in Pharmaceutical Sciences, 2018
Due to resistance of some epileptic patients to the current medications and the general incidence of severe side effects of these drugs, development and discovery of novel antiepileptic drugs is crucial.
Marzieh Rahmani Khajouei, Ahmad Mohammadi-Farani, Aref Moradi, Alireza Aliabadi   +3 more
doaj   +1 more source

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics [PDF]

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Casey, Lorraine A., Galt, Ronald H. B., Hadfield, Peter S., Page, Michael I., Vilanova, Bartholomew   +4 more
core   +1 more source

An update on the synthesis and reactivity of spiro-fused β-lactams [PDF]

, 2018
Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic ...
D'hooghe, Matthias, Dao Thi, Hang
core   +1 more source