Results 11 to 20 of about 660,493 (200)

Evaluation of Anti-Neuroinflammatory Activity of Isatin Derivatives in Activated Microglia [PDF]

Molecules, 2023
Neuroinflammation plays a crucial role in the progression of Alzheimer’s disease and other neurodegenerative disorders. Overactivated microglia cause neurotoxicity and prolong the inflammatory response in many neuropathologies.
Alejandro Cenalmor, José Ramón Suárez, García Álvarez, Isabel, Pascual, Elena, Isabel García-Álvarez, Cenalmor Molina, Alejandro, Cenalmor, Alejandro, Ramón Suárez, José, Elena Pascual, Pascual Vega, Elena, Rafael Correa-Rocha, Gil-Manso, Sergio, Sergio Gil-Manso, García-Álvarez, Isabel, Correa-Rocha, Rafael, Suárez Álvarez, José Ramón, Suárez, José Ramón   +16 more
core   +2 more sources

Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives [PDF]

Journal of Chemistry, 2015
Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation.
Ayman El-Faham, Wael N. Hozzein, Mohammad A. M. Wadaan, Sherine N. Khattab, Hazem A. Ghabbour, Hoong-Kun Fun, Mohammed Rafiq Siddiqui   +6 more
doaj   +2 more sources

Syntheses and Pharmacological Activities of Isatin Derivatives [PDF]

Journal of Drug Delivery and Therapeutics, 2019
Twenty derivatives of isatin (1H-indole-2, 3-Dione) were synthesized by the schematic route as per as scheme. These were further characterized by spectroscopic analysis. All the novel synthesized derivatives of isatin were screened for their antimicrobial activity against Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Streptococcus ...
Asif Husain, Sushil Kumar, Neetu Sachan, Mayank Yadav   +3 more
openaire   +2 more sources

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies. [PDF]

J Appl Toxicol
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Köprü S, Baran M, Gündüz MG, Doğan ŞD.   +3 more
europepmc   +2 more sources

Synthesis, antimicrobial and antioxidative activity of some new isatin derivatives [PDF]

Journal of the Serbian Chemical Society, 2014
The isatin derivatives, Schiff bases, were synthesized by the reaction of isatin and various substituted primary amines and characterized by several spectroscopic methods.
Šekularac Gavrilo M., Nikolić Jasmina B., Petrović Predrag, Bugarski Branko, Đurović Boban, Drmanić Saša Ž.   +5 more
doaj   +3 more sources

Design, Synthesis, and Biological Evaluation of Molecular Hybrids Incorporating Coumarin-Pyrazole-Linked Indolinone Derivatives With Antioxidant and Anti-Alzheimer Properties. [PDF]

Chem Biodivers
ABSTRACT The increase in global life expectancy has resulted in a significant rise in the occurrence of Alzheimer's disease (AD), making it a critical public health burden. Therefore, there is an urgent need to create effective methods to prevent or slow down the progression of the disease.
Sabt A, Aboulthana WM, Saleh AM, Ibrahim HAA, Saleh A, Lei X, Srour AM.   +6 more
europepmc   +2 more sources

Exploring novel isatin derivatives as SARS-CoV-2 3CLpro inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
A series of novel isatin derivatives were synthesised by incorporating phenyl, biphenyl, naphthyl and indolyl moieties into the N-1 position and screened in vitro against SARS-CoV-2 3CLpro, respectively.
Jian Song, Cai Shi, Boning Yang, Jingxiang Yang, Caifei Huang, Jiaqi Liu, Shuwen Wu, Shuyuan Mo, Jian Yang   +8 more
doaj   +2 more sources

Design, Synthesis, Molecular Dynamics, and In Vitro Evaluation of Isatin-Based Quinazoline Derivatives as Potential Antidiabetic Agents. [PDF]

Chem Biodivers
A series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8) has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC50 = 18.49 ± 0.06 µM), similar to the reference drug acarbose (IC50 = 16.26 ± 0.02 µM).
Jaidka S, Kumar A, Basumatary C, Singh TG, Bhatia R.   +4 more
europepmc   +2 more sources

Targeting bacitracin resistance-associated histidine kinase (BraS) in MRSA with isatin and indazole derivatives [PDF]

Scientific Reports
The BraSR two-component system plays a crucial role in bacitracin sensing and resistance in Staphylococcus aureus, making the BraS histidine kinase an attractive antibacterial target. In this study, we applied a structure-based drug discovery approach to
Grijesh Jaiswal, Sandesh Telang, Tripti Shrivastava, Shantu Amin, Arun K. Sharma, Krishne Gowda, Sandeep Kumar Srivastava   +6 more
doaj   +2 more sources

Advances in Pharmacology of Isatin and its Derivatives: A Review [PDF]

, 2015
Isatin (1H-indole-2,3-dione), an indole derivative of plant origin, is involved in many pharmacological activities like antiallergic, antimalarial, antiviral and antimicrobial; isatin and its derivatives have been found to show promising results against ...
Maalik, Aneela, Khan, Farhan A
core   +1 more source