Results 11 to 20 of about 1,535,483 (232)

Morita–Baylis–Hillman reaction of acrylamide with isatin derivatives [PDF]

Beilstein Journal of Organic Chemistry, 2014
The Morita–Baylis–Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in ...
Dharmendra Kumar Tiwari, Kishor Chandra Bharadwaj, Radhey M. Singh   +2 more
core   +5 more sources

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors [PDF]

J Enzyme Inhib Med Chem, 2023
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities.
Moataz A. Shaldam, H. Almahli, A. Angeli, R. Badi, E. F. Khaleel, Abdelrahman I Zain-Alabdeen, Zainab M Elsayed, E. Elkaeed, Rofaida Salem, C. Supuran, Wagdy M. Eldehna, Haytham O. Tawfik   +11 more
semanticscholar   +2 more sources

Synthesis, Characterization, and Antibacterial Activity of New Isatin Derivatives [PDF]

Pharm Chem J, 2023
1H-indol-2,3-dione (isatin) class of biologically active compounds have analgesic, anti-microbial, anti-inflammatory, anti-tubercular, anti-proliferative properties, and is also useful for the treatment of SARS-CoV.
S. Nain, G. Mathur, Tulika Anthwal, Swapnil Sharma, Sarvesh Paliwal   +4 more
semanticscholar   +2 more sources

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease [PDF]

J Enzyme Inhib Med Chem, 2023
SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health and economy. Till producing successful vaccination strategies, the healthcare sectors suffered from the lack of effective therapeutic agents that could control the ...
Mai H. ElNaggar, Abdullah A. Elgazar, Ghada Gamal, S. M. Hamed, Zainab M Elsayed, M. El-Ashrey, A. Abood, Mahmoud A. El Hassab, A. M. Soliman, Ramadan A. El-domany, F. Badria, C. Supuran, Wagdy M. Eldehna   +12 more
semanticscholar   +2 more sources

Isatin derivatives as broad-spectrum antiviral agents: the current landscape [PDF]

Med Chem Res, 2022
In recent decades, several viruses have resulted in large outbreaks with serious health, economic and social consequences. The current unprecedented outbreak of the new coronavirus, SARS-COV-2, necessitates intensive efforts for delivering effective ...
T. Elsaman, M. Mohamed, E. Eltayib, H. Abdel‐Aziz, A. E. Abdalla, Muhammad Usman Munir, M. A. Mohamed   +6 more
semanticscholar   +2 more sources

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies [PDF]

J Enzyme Inhib Med Chem, 2022
New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed comparable
E. Elkaeed, Mohammed S. Taghour, H. Mahdy, Wagdy M. Eldehna, N. El-Deeb, A. Kenawy, Bshra A Alsfouk, Mohammed A. Dahab, A. Metwaly, I. Eissa, M. El-Zahabi   +10 more
semanticscholar   +2 more sources

Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors [PDF]

Int J Mol Sci, 2022
Tumors are still one of the main causes of death; therefore, the search for new therapeutic agents that will enable the implementation of effective treatment is a significant challenge for modern pharmacy. One of the important factors contributing to the
Przemysław Czeleń, Agnieszka Skotnicka, Beata Szefler   +2 more
semanticscholar   +2 more sources

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19 [PDF]

Chem Zvesti, 2022
The world is now facing intolerable damage in all sectors of life because of the deadly COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2.
M. Ilyas, S. Muhammad, J. Iqbal, S. Amin, A. Al-Sehemi, H. Algarni, S. S. Alarfaji, M. Alshahrani, K. Ayub   +8 more
semanticscholar   +2 more sources

Design, Synthesis of New 1,2,4-Triazole/1,3,4-Thiadiazole with Spiroindoline, Imidazo[4,5-b]quinoxaline and Thieno[2,3-d]pyrimidine from Isatin Derivatives as Anticancer Agents [PDF]

Molecules, 2022
The current work aims to design and synthesis a new series of isatin derivatives and greatly enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino (pyridine) methyl) indolin-2-one, 2-((oxoindoline) amino) benzoic acid ...
A. Abu‐Hashem, S. Al-Hussain
semanticscholar   +2 more sources

Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives [PDF]

Molecules, 2022
Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, and tested for their interactions with ds-DNA. Theoretical and experimental findings showed good compatibility and indicated compound–DNA binding by ...
N. Arshad, Muhammad Ismail Mir, Fouzia Perveen, A. Javed, Memona Javaid, A. Saeed, P. Channar, S. I. Farooqi, S. H. Alkahtani, J. Anwar   +9 more
semanticscholar   +2 more sources