Results 21 to 30 of about 3,007 (178)

Interaction Study of 1, 3 Substituted Isatin Derivatives with Anti Inflammatory Properties with Cyclooxygenase 1 and 2 Enzymes by Molecular Docking Method

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Inflammation as the body's defense response is accompanied with various diseases. Prostaglandins are major mediators of inflammation produced by the cyclooxygenase enzymes.
Elham Jafari, Farshid Hassanzadeh, Nahal khayambashi, Valiollah Hajhashemi   +3 more
doaj  

Effect of Structure on Charge Distribution in the Isatin Anions in Aprotic Environment: Spectral Study

Molecules, 2017
Five isatin anions were prepared by deprotonation of initial isatins in aprotic solvents using basic fluoride and acetate anions (F− and CH3COO−). The F− basicity is sufficient to deprotonate isatin NH hydrogen from all the studied compounds.
Pavol Tisovský, Róbert Šandrik, Miroslav Horváth, Jana Donovalová, Klaudia Jakusová, Marek Cigáň, Róbert Sokolík, Anton Gáplovský, Martin Gáplovský, Juraj Filo   +9 more
doaj   +1 more source

Synthesis, Antimicrobial, and Anticancer Activities of Novel Nitrofuran Derivatives

Journal of Chemistry, 2023
Keeping in view the varying therapeutic attributes of 5-nitrofuran and isatin derivatives, novel 5-nitrofuran‒isatin molecular hybrids (2, 5–7) were synthesized by standard protocols, characterized by various spectroscopic techniques, and eventually ...
Malik Suliman Mohamed, Khaled M. Elamin, Rawaf Alenazy, Eyman Mohamed Eltayib, Mona Timan Idriss, Noura A. A. Alhudaib, Tilal Elsaman, Magdi Awadalla Mohamed   +7 more
doaj   +1 more source

N-Alkyl-Substituted Isatins Enhance P2X7 Receptor-Induced Interleukin-1β Release from Murine Macrophages

Mediators of Inflammation, 2016
Extracellular adenosine 5′-triphosphate (ATP) activates the P2X7 receptor channel to induce the rapid release of the proinflammatory cytokine, interleukin- (IL-) 1β, from macrophages. Microtubule rearrangements are thought to be involved in this process.
Ronald Sluyter, Kara L. Vine
doaj   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

Journal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay, Cansu Topkaya, Elif Kağa, Yasin Eren, Ramazan Güp   +4 more
wiley   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni, Maria Luisa Di Paolo, Antonio Laghezza, Giorgio Cozza, Francesco Piazzola, Laura Facci, Emma Marcolin, Elena Roggiolani, Luca Piemontese, Anna Minarini, Morena Zusso, Lisa Dalla Via, Michela Rosini   +12 more
wiley   +1 more source

Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives

Molecules, 2005
Iminoester hydrochlorides 1 have been synthesized. These compounds werethen converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new seriesof substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared.Finally a set ...
Bahittin Kahveci
doaj   +1 more source

Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions

Heliyon, 2022
An efficient and facile one-pot, five-component reaction for the synthesis of 2,6-diamino-1-alkyl-2-oxospiro[indoline-3,4′-thiopyran]-3,5-dicarbonitrile derivatives has been reported by a reaction between primary amines, carbon disulfide, malononitrile ...
F. Matloubi Moghaddam, Bagher Aghamiri
doaj   +1 more source

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source