Novel N-Substituted Amino Acid Hydrazone-Isatin Derivatives: Synthesis, Antioxidant Activity, and Anticancer Activity in 2D and 3D Models In Vitro [PDF]
Int J Mol Sci, 2021 A series of novel mono and bishydrazones each bearing a 2-oxindole moiety along with substituted phenylaminopropanamide, pyrrolidin-2-one, benzimidazole, diphenylmethane, or diphenylamine fragments were synthesized, and their anticancer activities were ...
I. Tumosienė +4 more
semanticscholar +2 more sources
Pharmacological Reports, 2013 Isatin, 1H-indole-2,3-dione, is a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, a precursor for a large number of pharmacologically active compounds.
Parvaneh Pakravan +2 more
exaly +2 more sources
Synthesis, antimicrobial and antioxidative activity of some new isatin derivatives [PDF]
Journal of the Serbian Chemical Society, 2014 The isatin derivatives, Schiff bases, were synthesized by the reaction of isatin and various substituted primary amines and characterized by several spectroscopic methods.
Šekularac Gavrilo M. +5 more
doaj +3 more sources
Early pharmacological profiling of isatin derivatives as potent and selective cytotoxic agents
Biochemical PharmacologyIsatin derivatives have attracted a lot of interest for their potential in the development of new anticancer drugs. A library of 38 isatin derivatives, created through an Ugi four-component reaction, underwent an initial screening in a panel of six human
Fernandes, Miguel Xavier, +15 more
core +2 more sources
Synthesis and Antiproliferatory Activities Evaluation of Multi-Substituted Isatin Derivatives [PDF]
Molecules, 2020 A series of multi-substituted isatin derivatives were synthesized using the powerful Sandmeyer reaction. The structures of these derivatives were confirmed by 1H-NMR, 13C-NMR, and HR-MS. Inhibition of proliferation activities of these derivatives against
Ying Ding +7 more
semanticscholar +2 more sources
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease [PDF]
Molecules, 2020 Thirty-six novel indole-containing compounds, mainly 3-(2-phenylhydrazono) isatins and structurally related 1H-indole-3-carbaldehyde derivatives, were synthesized and assayed as inhibitors of beta amyloid (Aβ) aggregation, a hallmark of pathophysiology ...
Rosa Purgatorio +9 more
semanticscholar +2 more sources
Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies [PDF]
J Biomol Struct Dyn, 2020 SARS-COV-2, the novel coronavirus and root of global pandemic COVID-19 caused a severe health threat throughout the world. Lack of specific treatments raised an effort to find potential inhibitors for the viral proteins.
V. N. Badavath +7 more
semanticscholar +2 more sources
Synthesis and spectroscopic analysis of Schiff Bases of Imesatin and Isatin derivatives
Journal of Applied Sciences and Environmental Management, 2016 A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported.
Olubunmi S. Oguntoye +5 more
doaj +3 more sources
Synthesis, spectroscopic studies, and antioxidant activities of novel thio/carbohydrazones and bis-isatin derivatives from terephthalaldehyde [PDF]
Turk J Chem, 2020 New bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol.
H. Muğlu, Hasan Yakan, T. Bakır
semanticscholar +2 more sources
Isatin derivatives in reactions with phosphorus(III–V) compounds [PDF]
Chemistry of Heterocyclic Compounds, 2015 In this review we generalize and analyze information about reactions between isatin and three-, four-, and five-coordinate phosphorus compounds, published between 1966 and 2014.
Musin, Lenar I. +2 more
openaire +3 more sources