Results 31 to 40 of about 7,252 (218)

Syntheses and Characterizations of Some New N-alkyl, Isoxazole and Dioxazole Derivatives of 5-Chloroisatin [PDF]

, 2017
N-alkyl and cycloadducts derivatives of 5-Chloroisatin were synthesized in good to excellent yields. The method evidences a selective N-alkylation when using 1,2-bis (2-chloroethoxy) ethane as efficient spacer at room temperature on the 5-Chloroisatin ...
Rodi, Y. K. (Y), Senhaji, O. (O), Skalli, M. K. (M), Tribak, Z. (Z)   +3 more
core   +1 more source

Synthesis and characterization of novel Mannich's bases incorporated with Ibuprofen an Biginelli Derivatives

Tikrit Journal of Pure Science, 2023
In this work, a series of novel Mannich's bases incorporated with Ibuprofen core and Biginelli derivatives have been reported. The synthesis process was dependent on linking Ibuprofen hydrazone with Isatin to Biginelli derivatives via methylene group of
Layth W. Abdullah, Hanaa K.Saleh, Mustafa R. Aeyyd   +2 more
doaj   +1 more source

Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

Open Chemistry, 2021
This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity.
Santoso Mardi, Fadlan Arif, Fahmi Muhammad Riza Ghulam, Rahmayanti Ardhana   +3 more
doaj   +1 more source

Isatin thiosemicarbazone-blended polymer films for biomedical applications : surface morphology, characterisation and preliminary biological assessment [PDF]

, 2016
Poly (methyl methacrylate) and polyurethane are polymers currently used for a range of biomedical applications. To modify their surface characteristics, biocompatibility and potentially reduce any related side effects the addition to the polymers of ...
Alexiou, Polyxeni, Lamprou, Dimitrios A., Mallinson, David, Mullen, Alexander B., Pelecanou, Maria, Sagnou, Marina   +5 more
core   +1 more source

Electronic structure, reactivity, and predicted biological activity of halogenated isatin-pyridine Schiff bases: a DFT study [PDF]

Pharmacia
Isatin derivatives have been at the forefront of pharmaceutical research, displaying a wide range of biological activities, including antioxidant, antimicrobial, and anticancer properties. In this study, twelve isatin-pyridine Schiff bases were evaluated
Nikolay Toshev, Armina Abdollahi, Kaloyan Mihalev, Ivelin Iliev, Yordanka Uzunova, Vassil Delchev, Nadya Agova, Svetlana Georgieva   +7 more
doaj   +3 more sources

Synthesis, Antimicrobial, and Anticancer Activities of Novel Nitrofuran Derivatives

Journal of Chemistry, 2023
Keeping in view the varying therapeutic attributes of 5-nitrofuran and isatin derivatives, novel 5-nitrofuran‒isatin molecular hybrids (2, 5–7) were synthesized by standard protocols, characterized by various spectroscopic techniques, and eventually ...
Malik Suliman Mohamed, Khaled M. Elamin, Rawaf Alenazy, Eyman Mohamed Eltayib, Mona Timan Idriss, Noura A. A. Alhudaib, Tilal Elsaman, Magdi Awadalla Mohamed   +7 more
doaj   +1 more source

Ruthenium catalyzed oxidative conversion of isatins to anthranilic acids: Mechanistic study [PDF]

, 2008
Oxidation of isatins (isatin, 5-methylisatin, 5-bromoisatin, and 5-nitroisatin) to their corresponding anthranilic acids was performed with sodium N-bromo-p-toluenesulfonamide or bromamine-T (BAT) as an oxidant and ruthenium trichloride (Ru(III)) as a ...
Gowda, N.M.N., Jagadeesh, R.V., Puttaswamy, ., Vaz, N.   +3 more
core   +1 more source

Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]

, 2020
Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles, Huertas Castaño, Carlos, Pardal Redondo, Ricardo, Vega Moreno, Francisco Manuel   +3 more
core   +1 more source

Interaction Study of 1, 3 Substituted Isatin Derivatives with Anti Inflammatory Properties with Cyclooxygenase 1 and 2 Enzymes by Molecular Docking Method

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Inflammation as the body's defense response is accompanied with various diseases. Prostaglandins are major mediators of inflammation produced by the cyclooxygenase enzymes.
Elham Jafari, Farshid Hassanzadeh, Nahal khayambashi, Valiollah Hajhashemi   +3 more
doaj  

Molecular docking and synthesis of N-alkyl-isatin-3-imino aromatic amine derivatives and their antileishmanial and cytotoxic activities

Research in Pharmaceutical Sciences
Background and purpose: Isatin derivatives have excited attention due to their biological attractions, especially, anticancer properties. Isatin analogs such as semaxanib and sunitinib were exposed to tyrosine kinase inhibitory properties.
Farshid Hassanzadeh, Seyed Hossein Hejazi, Elham Jafari, Atefeh Mohammadi fard, Hojjat Sadeghi-aliabadi   +4 more
doaj   +1 more source