Results 51 to 60 of about 660,493 (200)

Enantioselective Solvent-Free Synthesis of 3-Alkyl-3-hydroxy-2-oxoindoles Catalyzed by Binam-Prolinamides

Molecules, 2015
BINAM-prolinamides are very efficient catalyst for the synthesis of non-protected and N-benzyl isatin derivatives by using an aldol reaction between ketones and isatins under solvent-free conditions.
Abraham Bañn-Caballero, Jesús Flores-Ferrándiz, Gabriela Guillena, Carmen Nájera   +3 more
doaj   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions

Heliyon, 2022
An efficient and facile one-pot, five-component reaction for the synthesis of 2,6-diamino-1-alkyl-2-oxospiro[indoline-3,4′-thiopyran]-3,5-dicarbonitrile derivatives has been reported by a reaction between primary amines, carbon disulfide, malononitrile ...
F. Matloubi Moghaddam, Bagher Aghamiri
doaj   +1 more source

Synthesis of Spiro Heterocyclic Compounds

E-Journal of Chemistry, 2010
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III).
Mohamed N. Ibrahim, Mohamed F. El-Messmary, Mohamed G. A. Elarfi   +2 more
doaj   +1 more source

SYNTHESIS AND ANTIMICROBIAL SCREENING OF 2,6-DIAMINOPYRIDINE SCHIFF BASES OF ISATIN DERIVATIVES [PDF]

, 2023
Objective: Synthesis and in vitro antimicrobial screening of 2,6-diaminopyridine Schiff bases of isatin derivatives. Methods: Isatin and it’s 5-substituted derivatives (S1-5) were prepared by Sandmeyer method and N2-Benzylidenepyridine-2,6-Diamine (M ...
SHRIVASTAVA, SHOBHIT, AHUJA, DHARMENDRA
core   +1 more source

SYNTHETIC APPROACHES OF ISATIN DERIVATIVES AS AN ANTI-CANCER AGENT [PDF]

Isatin (1H-Indole-2,3-dione) and its derivatives are an important class of Heterocyclic compounds and are majorly used as a Precursor for drug Synthesis.
Rana, Nehal, Hiwase, Chetna P., Gandhi, Priya, Mishra, Megha, Lahariya, Chetana A., O. Nasare, Shivani, Gandhi, Nehal, Hapani, Ayushi, D. Nirmal, Kalyani   +8 more
core   +1 more source

On‐DNA Nitro Reduction for Use in DNA‐Encoded Library Synthesis: Methods, Applications, and Challenges

Asian Journal of Organic Chemistry, Volume 15, Issue 10, October 2026.
Reducing aryl nitro groups provides DNA‐linked anilines for use in benzimidazole synthesis and other scaffold‐forming reactions during the construction of DNA‐encoded libraries. This review examines transfer hydrogenation and Fe(II)‐, dithionite/viologen‐, diboron‐, and Pd‐based methods, focusing on how reaction efficiency, chemoselectivity, DNA ...
Yeongjoo Suh, Yeongyeon Lee, Yujin Han, Hongjun Jeon   +3 more
wiley   +1 more source

A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

, 2017
A highly efficient approach for the selective synthesis of bioactive oxindole/isatin-N-acetamide derivatives via Pd-catalyzed intramolecular amination has been developed.
Yubo Pang, Runsheng Zeng, Mingyu Guan, Yingsheng Zhao   +3 more
core   +1 more source

A Green Sample Preparation Procedure for Determining Proline in Honey and Wine by Visible Molecular Absorption Spectrophotometry After Microwave‐Assisted Derivatization

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
A green, simple, and rapid method quantifies proline in wine and honey. Microwave‐assisted derivatization and ultrasonic cooling drastically reduced reaction and cooling times. The validated spectrophotometric method shows high accuracy (95.7%–109.4% recovery) and is an eco‐friendly alternative, confirmed by the AGREEPrep (Analytical GReenness metric ...
Amanda de Aguiar Barreto, Maryellen Batista dos Santos, Alexia Tamyres Moreira Silva Barberino, Lara Pinto de Araújo, Madson Moreira Nascimento, Raildo Mota de Jesus, Ivon Pinheiro Lôbo   +6 more
wiley   +1 more source

Synthesis, Anti‐Leishmania amazonensis Activity, Cytotoxicity, and Molecular Docking of Anthranilate–Naphthoquinone Hybrids

ChemistrySelect, Volume 11, Issue 40, 27 October 2026.
New anthranilate–naphthoquinone hybrids display potent inhibition of Leishmania (L.) amazonensis with low host cell toxicity. Molecular docking reveals key interactions with TR, GP63, and PTR1, suggesting a multitarget mechanism that contributes to parasite death.
Eduardo Miranda da Silva Magesfeste, Lidilhone Hamerski, Diego Mendes Nunes, Ana Paula Sotero da Silva Ribeiro, Elvira Maria Saraiva, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Bárbara Vasconcellos da Silva   +7 more
wiley   +1 more source