Results 51 to 60 of about 3,007 (178)

Antidiabetic and Cytotoxicity Studies of Novel Quinazolinone–1,3,4‐Thiadiazole Molecular Hybrids

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
ABSTRACT In the treatment of diabetes mellitus (DM), inhibition of carbohydrate‐hydrolysing enzymes, such as α‐amylase, has emerged as a promising therapeutic strategy. In the present study, a series of quinazolinone‐1,3,4‐thiadiazole molecular hybrids were designed, synthesized and biologically evaluated for their antidiabetic potential.
Prishani Kisten, Pule Seboletswe, Gobind kumar, Nontobeko Gcabashe, Neha Manhas, Ankit, Almahi Idris, Md. Shahidul Islam, René Khan, Parvesh Singh   +9 more
wiley   +1 more source

Antidiabetic Evaluation of Thiosemicarbazone Analogs Through α‐Amylase Inhibition Complemented With Computational Studies

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Thiosemicarbazones were evaluated for antidiabetic activity via α‐amylase inhibition. Compound 6g showed two‐fold greater potency than acarbose. Benzaldehyde‐ and ketone‐derived analogues were most active, while isatin and furan derivatives were less effective. Several compounds displayed antioxidant activity. Docking highlighted hydrogen bonding and π–
Neha Manhas, Gobind Kumar, Ankit, Nagaraju Kerru, Pule Seboletswe, Nontobeko Gcabashe, Almahi Idris, Md. Shahidul Islam, Talent Makhanya, Parvesh Singh   +9 more
wiley   +1 more source

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions

Heliyon, 2020
A sequential multi-component reaction of the nitroketene dithioacetals, cysteamine hydrochloride, isatin and different CH-acids is described. This efficient method provides new functionalized thiazolo pyridine-fused spirooxindoles and thiazolo ...
Shima Nasri, Mohammad Bayat, Hassan Vasheghani Farahani, Solmaz Karami   +3 more
doaj   +1 more source

Characterization of the Orphan Cytochrome P450 CYP107J1 From Bacillus subtilis Through Peroxygenase Activity Engineering

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
The orphan cytochrome P450 CYP107J1 with unknown redox partners was rationally modified into H2O2‐driven form. The QE (E251Q/T252E) mutant produced valuable chemicals by simply mixing the enzyme with substrate and H2O2. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising ...
Hideki Kato, Takafumi Hashimoto, Tuhin Das, Daniel Z. Doherty, Stephen G. Bell, Toshiki Furuya   +5 more
wiley   +1 more source

Metal‐Catalyzed C(sp2)–H Bond Functionalization of Indolinone‐ and Indanone‐Type Chemical Platforms En Route Toward Late‐Stage Functionalization

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
An in‐depth survey dealing with the aromatic C—H bond functionalization of biologically‐relevant scaffolds featuring the indolinone and indanone core is discussed as they are unique aromatic scaffolds that are 1,2‐doubly fused with small five‐membered rings.
Vanessa Delahaye, Sylvie Dérien, Mathieu Achard, Rafael Gramage‐Doria   +3 more
wiley   +1 more source

Harnessing Toluene Solvent as a Reactant: Regioselective Benzyl Radical Addition to Multi‐π 1,5‐Enynes in a Copper‐Catalyzed Cascade to Indenes

Chemistry – A European Journal, Volume 32, Issue 14, 15 April 2026.
A copper‐catalyzed three‐component radical cascade of 1,5‐enynes with toluene and benzoic acids enables regioselective benzyl radical addition to multi‐Π systems, efficiently delivering polysubstituted indenes from an abundant solvent feedstock. ABSTRACT C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an ...
Saideh Rajai‐Daryasarei, Fatemeh Chahardehi, Mohammad Mahdi Sharifani, Morteza Jamshidi, Robert Stranger, Frank Rominger, Alireza Ariafard, Saeed Balalaie   +7 more
wiley   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Targeting bacitracin resistance-associated histidine kinase (BraS) in MRSA with isatin and indazole derivatives

Scientific Reports
The BraSR two-component system plays a crucial role in bacitracin sensing and resistance in Staphylococcus aureus, making the BraS histidine kinase an attractive antibacterial target. In this study, we applied a structure-based drug discovery approach to
Grijesh Jaiswal, Sandesh Telang, Tripti Shrivastava, Shantu Amin, Arun K. Sharma, Krishne Gowda, Sandeep Kumar Srivastava   +6 more
doaj   +1 more source

Evaluation of Anti-Neuroinflammatory Activity of Isatin Derivatives in Activated Microglia. [PDF]

Molecules, 2023
Cenalmor A, Pascual E, Gil-Manso S, Correa-Rocha R, Suárez JR, García-Álvarez I.   +5 more
europepmc   +1 more source

Synthesis, Characterization, and Antibacterial Activity of New Isatin Derivatives. [PDF]

Pharm Chem J, 2023
Nain S, Mathur G, Anthwal T, Sharma S, Paliwal S.   +4 more
europepmc   +1 more source