Results 51 to 60 of about 7,252 (218)

Characterization of the Orphan Cytochrome P450 CYP107J1 From Bacillus subtilis Through Peroxygenase Activity Engineering

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
The orphan cytochrome P450 CYP107J1 with unknown redox partners was rationally modified into H2O2‐driven form. The QE (E251Q/T252E) mutant produced valuable chemicals by simply mixing the enzyme with substrate and H2O2. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising ...
Hideki Kato, Takafumi Hashimoto, Tuhin Das, Daniel Z. Doherty, Stephen G. Bell, Toshiki Furuya   +5 more
wiley   +1 more source

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity

Molecules, 2022
Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis.
Francesca Bonvicini, Alessandra Locatelli, Rita Morigi, Alberto Leoni, Giovanna Angela Gentilomi   +4 more
doaj   +1 more source

Synthesis, Characterization and Biological Activities of a New 5-Chloroisatin Schiff Base and its Metal Complexes [PDF]

, 2013
Copper(II), cobalt(II), nickel(II) and zinc(II) complexes of 5-chloroisatin Schiff base (L) (L= Schiff base derived from 5-chloroisatin and 2-methyl-4- nitro aniline) were synthesized and characterized.
Mahendra, K.N., Raghavendra Rao, ., Ramakrishna Reddy, K.   +2 more
core   +1 more source

Metal‐Catalyzed C(sp2)–H Bond Functionalization of Indolinone‐ and Indanone‐Type Chemical Platforms En Route Toward Late‐Stage Functionalization

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
An in‐depth survey dealing with the aromatic C—H bond functionalization of biologically‐relevant scaffolds featuring the indolinone and indanone core is discussed as they are unique aromatic scaffolds that are 1,2‐doubly fused with small five‐membered rings.
Vanessa Delahaye, Sylvie Dérien, Mathieu Achard, Rafael Gramage‐Doria   +3 more
wiley   +1 more source

Synthesis, Characterisation and Biological Activity Screening Of Schiff Base Ligands Containing Isatin and Their Metal Complexes [PDF]

, 2008
Six new Schiff bases formed from the condensation reaction of S-benzyldithiocarbazate (SBDTC) and S-methyldithiocarbazate (SMDTC) with selected diketones containing isatin derivatives namely isatin, 5-fluroisatin, 5-chloroisatin, 5-bromoisatin and ...
Abdul Manan, Mohd Abdul Fatah
core  

Synthesis of novel Glycoconjugates derived from Alkynyl heterocycles through a click approach [PDF]

, 2013
Accepted author version posted online: 05 Jun 2012The synthesis of a series of novel 1,4-disubstituted 1,2,3-triazole compounds bearing a D-glucose derivative and an heteroaromatic system is described.
Ana M. F. Oliveira-Campos, Ana P. Esteves, Aragão-Leoneti V., Goutarel R., João C. O. Gonçalves, Lígia M. Rodrigues, Marília Silva   +6 more
core   +1 more source

Harnessing Toluene Solvent as a Reactant: Regioselective Benzyl Radical Addition to Multi‐π 1,5‐Enynes in a Copper‐Catalyzed Cascade to Indenes

Chemistry – A European Journal, Volume 32, Issue 14, 15 April 2026.
A copper‐catalyzed three‐component radical cascade of 1,5‐enynes with toluene and benzoic acids enables regioselective benzyl radical addition to multi‐Π systems, efficiently delivering polysubstituted indenes from an abundant solvent feedstock. ABSTRACT C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an ...
Saideh Rajai‐Daryasarei, Fatemeh Chahardehi, Mohammad Mahdi Sharifani, Morteza Jamshidi, Robert Stranger, Frank Rominger, Alireza Ariafard, Saeed Balalaie   +7 more
wiley   +1 more source

Facile synthesis of Schiff and Mannich bases of isatin derivatives [PDF]

, 2015
We report herein on the synthesis of some isatin Schiff’s bases (1–11), which were prepared from the reaction of isatin and some aromatic amines. These in turn were converted to the corresponding Mannich bases (12-23) by reaction with a number of ...
Al-azzawi, Nuhad K. E., Al-kadhimi, Ahmed A. H., Khalaf, Abedawn I.   +2 more
core  

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Iodine-catalyzed Synthesis, Antibacterial, and Antioxidant Activity of Isatin Derivatives

Indonesian Journal of Chemistry
Isatin is a unique compound with many bioactivities such as antiviral, anti-HIV, antitumor, anti-inflammatory, anticonvulsant, and antifungal. In this study, isatin derivatives were synthesized with an iodine catalyst and tested for antibacterial and ...
Antonius Herry Cahyana, Agus Rimus Liandi, Yosua Ongkowidjawa   +2 more
doaj   +1 more source