Results 71 to 80 of about 3,007 (178)

Isatin derivatives as broad-spectrum antiviral agents: the current landscape. [PDF]

Med Chem Res, 2022
Elsaman T, Mohamed MS, Eltayib EM, Abdel-Aziz HA, Abdalla AE, Munir MU, Mohamed MA.   +6 more
europepmc   +1 more source

Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity

International Journal of Nanomedicine, 2014
Ayman El-Faham,1,2 Ahmed A Elzatahry,1,3 Zeid A Al-Othman,1 Elsayed Ahmed Elsayed4,5 1Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia,
El-Faham A, Elzatahry AA, Al-Othman ZA, Elsayed EA   +3 more
doaj  

Design and Optimization of Spiro-Isatin-Thiazolidinone Hybrids with Promising Anticancer Activity

Pharmaceuticals
Background: Cancer remains a leading cause of morbidity and mortality worldwide, and current therapies are limited by toxicity, cost, and resistance. Inhibition of the MDM2–p53 interaction is a promising anticancer strategy, as this pathway is frequently
Dmytro Khylyuk, Serhii Holota, Natalia Finiuk, Rostyslav Stoika, Tetyana Rumynska, Roman Lesyk   +5 more
doaj   +1 more source

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19. [PDF]

Chem Zvesti, 2022
Ilyas M, Muhammad S, Iqbal J, Amin S, Al-Sehemi AG, Algarni H, Alarfaji SS, Alshahrani MY, Ayub K.   +8 more
europepmc   +1 more source

Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening. [PDF]

RSC Med Chem, 2023
Jiang X, Li J, Viayna A, Luque FJ, Woodson M, Jing L, Gao S, Zhao F, Xie M, Toth K, Tavis J, Tollefson AE, Liu X, Zhan P.   +13 more
europepmc   +1 more source

Synthesis, Characterization, Molecular Docking, and Antimicrobial Evaluation of New Acetylenic Mannich Bases of Isatin–Thiazole Derivatives

Iraqi Journal of Pharmaceutical Sciences
The isatin molecule is present in many natural substances, like plants and animals, and it is utilized to prepare compounds with various biological activities.
marwa hashim almusawi, May Mohammed Jawad Al-Mudhafar   +1 more
doaj   +1 more source

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies. [PDF]

J Enzyme Inhib Med Chem, 2022
Elkaeed EB, Taghour MS, Mahdy HA, Eldehna WM, El-Deeb NM, Kenawy AM, A Alsfouk B, Dahab MA, Metwaly AM, Eissa IH, El-Zahabi MA.   +10 more
europepmc   +1 more source

Cytotoxic Effects of Dibromoisatin Derivatives on Hela and HepG2 Cell Lines Using MTT Assay

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Tumors are one of the most important threats to human life and improving the drugs used in their treatment is always necessary.  Isatin is found in many plants and also synthesized through different methods.
Mohammad Shokrzadeh, Saied Emami, Melika Amirzadeh, Mona Modanloo   +3 more
doaj  

Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives. [PDF]

Molecules, 2022
Arshad N, Mir MI, Perveen F, Javed A, Javaid M, Saeed A, Channar PA, Farooqi SI, Alkahtani S, Anwar J.   +9 more
europepmc   +1 more source

Evaluation of the Antibacterial Activity of Isatin against Campylobacter jejuni and Campylobacter coli Strains

Applied Microbiology
Antibiotic resistance, particularly against fluoroquinolones and macrolides, has emerged globally among thermophilic Campylobacters (Campylobacter jejuni and Campylobacter coli), giving rise to concerns about the efficacy of antibiotic treatment of these
Claudia B. Barroso, Liliane M. Seki, Wagner T. C. Esteves, Michele C. Nascimento, Aurea Echevarria   +4 more
doaj   +1 more source