, 1991 A simple procedure based upon capillary column gas chromatography-mass spectrometry (GC—MS) is described for the detection and determination of isatin (indole-2,3-dione) in body fluids and tissues. After addition of 5-methylisatin as internal standard to
Watkins, P.J. +6 more
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New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies. [PDF]
J Enzyme Inhib Med Chem, 2022 Elkaeed EB +10 more
europepmc +1 more source
STUDY OF ANTIMICROBIAL, ANALGESIC AND ANTICONVULSANT ACTIVITY OF NOVEL ISATIN DERIVATIVES [PDF]
, 2016 Isatin is an endogenous compound and possess a wide variety of biological activities. In the present investigation, a different isatin derivatives suchas novel isatin 3-[N-(4-substituted)-hydrazinyl-3-oxo prop 1-en-2yl) benzamides and their antimicrobial,
Chirra, Sravanthi +1 more
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Cytotoxic Effects of Dibromoisatin Derivatives on Hela and HepG2 Cell Lines Using MTT Assay
Journal of Mazandaran University of Medical Sciences, 2017 Background and purpose: Tumors are one of the most important threats to human life and improving the drugs used in their treatment is always necessary. Isatin is found in many plants and also synthesized through different methods.
Mohammad Shokrzadeh +3 more
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Biological activities of isatin and its derivatives [PDF]
, 2005 Izatin je endogeni spoj prisutan u organizmu čovjeka koji posjeduje niz farmakoloških učinaka. Izatin djeluje kao antioksidans, sedativ i antikonvulziv. In vitro je snažni antagonist na receptorima za natrijeve ione u atriju.
SRIDHAR, SESHAIAH KRISHNAN +3 more
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Morita–Baylis–Hillman reaction of acrylamide with isatin derivatives
, 2014 The Morita–Baylis–Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in ...
Dharmendra Kumar Tiwari +2 more
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Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives. [PDF]
Molecules, 2022 Arshad N +9 more
europepmc +1 more source
N-1,2,3-Triazole-isatin derivatives: anti-proliferation effects and target identification in solid tumour cell lines. [PDF]
RSC Med Chem, 2022 Busto N +6 more
europepmc +1 more source
Al-Mustansiriyah Journal of Pharmaceutical SciencesHistone deacetylase-2 (HDAC-2) is an important therapeutic target in cancer treatment. Isatin derivatives have attracted considerable interest in medicinal chemistry because of their diverse biological activities.
Hanan Adil Salih +3 more
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Synthesis and anti-inflammatory effects evaluation of 1,3 substituted isatin derivatives
, 2021 Objectives: Inflammation is a pathophysiological response of the body to a variety of agents including infections and physical injury leading to local accumulation of plasma fluid and blood cells.
Hassanzadeh, F. +3 more
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