Results 111 to 120 of about 1,535,483 (232)

Design and Optimization of Spiro-Isatin-Thiazolidinone Hybrids with Promising Anticancer Activity

Pharmaceuticals
Background: Cancer remains a leading cause of morbidity and mortality worldwide, and current therapies are limited by toxicity, cost, and resistance. Inhibition of the MDM2–p53 interaction is a promising anticancer strategy, as this pathway is frequently
Dmytro Khylyuk, Serhii Holota, Natalia Finiuk, Rostyslav Stoika, Tetyana Rumynska, Roman Lesyk   +5 more
doaj   +1 more source

BIOLOGICAL EVALUATION OF SCHIFF BASES OF NEW ISATIN DERIVATIVES FOR ANTI ALZHEIMER\u27S ACTIVITY

, 2014
Isatin can be used for synthesis of many heterocyclic compounds having diverse pharmacological activities. Several Isatin derivatives are being developed as promising drugs in the area of central nervous system diseases.
Rao. J, Venkateshwar, Mohan.P, Chandra
core  

Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives

, 2016
Tryptophan 2,3-dioxygenase (TDO) is a cytosolic protein with a proven immunomodulatory function that promotes tumoral immune resistance and proliferation. Despite the interest in TDO as a therapeutic target in cancer treatment, the number of biologically
Christopher G. Mowat (1270245), Georgios Pantouris (1340667), James Loudon-Griffiths (2617431)   +2 more
core   +1 more source

Biological activities of isatin and its derivatives

, 2005
Izatin je endogeni spoj prisutan u organizmu čovjeka koji posjeduje niz farmakoloških učinaka. Izatin djeluje kao antioksidans, sedativ i antikonvulziv. In vitro je snažni antagonist na receptorima za natrijeve ione u atriju.
MAYANK JYOTI, SIVAKUMAR SMITHA, SRIDHAR, SESHAIAH KRISHNAN, SURENDRA NATH PANDEYA, PANDEYA, SURENDRA NATH, SESHAIAH KRISHNAN SRIDHAR, SMITHA, SIVAKUMAR, JYOTI, MAYANK   +7 more
core  

Computational analysis of 3-monosubstituted isatin derivatives for physicochemical properties and drug-likeness

Isatin and its derivatives have garnered significant interest in medicinal chemistry due to their diverse pharmacological activities, including anticancer, antiviral, and antimicrobial effects.
Iliev, Ivelin; Medical University of Varna, Mihalev, Kaloyan; Medical University of Varna, Georgieva, Svetlana; Medical University of Varna   +2 more
core   +1 more source

A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

, 2017
A highly efficient approach for the selective synthesis of bioactive oxindole/isatin-N-acetamide derivatives via Pd-catalyzed intramolecular amination has been developed.
Yubo Pang, Runsheng Zeng, Mingyu Guan, Yingsheng Zhao   +3 more
core   +1 more source

Synthesis, Characterization, Molecular Docking, and Antimicrobial Evaluation of New Acetylenic Mannich Bases of Isatin–Thiazole Derivatives

Iraqi Journal of Pharmaceutical Sciences
The isatin molecule is present in many natural substances, like plants and animals, and it is utilized to prepare compounds with various biological activities.
marwa hashim almusawi, May Mohammed Jawad Al-Mudhafar   +1 more
doaj   +1 more source

Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening. [PDF]

RSC Med Chem, 2023
Jiang X, Li J, Viayna A, Luque FJ, Woodson M, Jing L, Gao S, Zhao F, Xie M, Toth K, Tavis J, Tollefson AE, Liu X, Zhan P.   +13 more
europepmc   +1 more source

Cytotoxic Effects of Dibromoisatin Derivatives on Hela and HepG2 Cell Lines Using MTT Assay

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Tumors are one of the most important threats to human life and improving the drugs used in their treatment is always necessary.  Isatin is found in many plants and also synthesized through different methods.
Mohammad Shokrzadeh, Saied Emami, Melika Amirzadeh, Mona Modanloo   +3 more
doaj  

Evaluation of the Antibacterial Activity of Isatin against Campylobacter jejuni and Campylobacter coli Strains

Applied Microbiology
Antibiotic resistance, particularly against fluoroquinolones and macrolides, has emerged globally among thermophilic Campylobacters (Campylobacter jejuni and Campylobacter coli), giving rise to concerns about the efficacy of antibiotic treatment of these
Claudia B. Barroso, Liliane M. Seki, Wagner T. C. Esteves, Michele C. Nascimento, Aurea Echevarria   +4 more
doaj   +1 more source