Biological activities of isatin and its derivatives.
Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and ...
Surendra Nath, Pandeya +3 more
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Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease. [PDF]
Purgatorio R +9 more
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Molecular diversity of the reactions of MBH carbonates of isatins and various nucleophiles
In this paper, the nucleophilic substitution reactions of various N- and P-containing nucleophiles to MBH carbonates of isatins were investigated. Diverse functionalized 3-substituted oxindole derivatives were successfully prepared in satisfactory yields
Zi-Ying Xiao, Jing Sun, Chao-Guo Yan
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Synthesis, spectroscopic studies, and antioxidant activities of novel thio/carbohydrazones and bis-isatin derivatives from terephthalaldehyde. [PDF]
MuĞlu H, Yakan H, Bakir TK.
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Electrolytic Reduction of Isatin and Its Derivatives. I. Reduction of Isatin [PDF]
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Tricyclic Isatin Derivatives as Anti-Inflammatory Compounds with High Kinase Binding Affinity. [PDF]
Uvarov AV +3 more
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Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates. [PDF]
Mukthapuram PR, Natarajan A.
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ELECTROLYTIC REDUCTION OF ISATIN AND ITS DERIVATIVES. Ⅱ.: REDUCTION OF N-METHYL ISATIN
N-methyl-isatin can be reduced by the same process as in the case of isatin only by controlling the conditions as follows: (1) It is reduced to N-methyl-dioxyindol with lead cathode suspended in 20% dilute sulphuric acid solution. (2) It is reduced to N-methyl-oxyindol with mercury cathode In natrium sulphate solution.
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Über Isatin‐anile. II. Derivate des Thionaphthenchinons [PDF]
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