Results 101 to 110 of about 1,535,483 (232)

SYNTHETIC APPROACHES OF ISATIN DERIVATIVES AS AN ANTI-CANCER AGENT

Isatin (1H-Indole-2,3-dione) and its derivatives are an important class of Heterocyclic compounds and are majorly used as a Precursor for drug Synthesis.
Rana, Nehal, Hiwase, Chetna P., Gandhi, Priya, Mishra, Megha, Lahariya, Chetana A., O. Nasare, Shivani, Gandhi, Nehal, Hapani, Ayushi, D. Nirmal, Kalyani   +8 more
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Synthesis and anti-inflammatory effects evaluation of 1,3 substituted isatin derivatives

, 2021
Objectives: Inflammation is a pathophysiological response of the body to a variety of agents including infections and physical injury leading to local accumulation of plasma fluid and blood cells.
Hassanzadeh, F., Hajhashemi, V., Jafari, E., Khayambashi, N.   +3 more
core  

Über Isatin‐anile. II. Derivate des Thionaphthenchinons [PDF]

Berichte der deutschen chemischen Gesellschaft, 1910
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openaire   +1 more source

Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity

Drug Design, Development and Therapy, 2022
Refaie M Kassab,1 Sami A Al-Hussain,2 Nooran S Elleboudy,3 Amgad Albohy,4 Magdi EA Zaki,2 Khaled AM Abouzid,5,6 Zeinab A Muhammad7 1Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt; 2Department of Chemistry, Faculty of ...
Kassab RM, Al-Hussain SA, Elleboudy NS, Albohy A, Zaki MEA, Abouzid KAM, Muhammad ZA   +6 more
doaj  

Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents

Journal of Enzyme Inhibition and Medicinal Chemistry
Isatin, known as 1H-indole-2,3-dione, was originally recognised as a synthetic molecule until its discovery in the fruits of the cannonball tree, Couroupita guianensis.
Mohammad Altamimi, Saeed Ali Syed, Burak Tuzun, Mohammad Rashid Alhazani, Osamah Alnemer, Ahmed Bari   +5 more
doaj   +1 more source

Crystal structure and Hirshfeld analysis of trans-bis(5-fluoroindoline-2,3-dione 3-oximato-κ2O2,N3)-trans-bis(pyridine-κN)copper(II)

Acta Crystallographica Section E: Crystallographic Communications, 2018
The reaction in methanol of CuII acetate monohydrate with 5-fluoroisatin 3-oxime deprotonated with KOH in a 1:2 molar ratio and recrystallization from pyridine yielded the title compound, [Cu(C8H4FN2O2)2(C5H5N)2].
Ana Paula Lopes de Melo, Leandro Bresolin, Bianca Barreto Martins, Vanessa Carratu Gervini, Adriano Bof de Oliveira   +4 more
doaj   +1 more source

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

PLoS Neglected Tropical Diseases, 2019
New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase ...
Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Veronica Gomez-Pérez, Luis Miguel Ruiz-Pérez, Domingo I Rojas-Barros, Francisco Gamarro, Dolores González-Pacanowska, María S Martínez-Martínez, Pilar Manzano, Lori Ferrins, Conor R Caffrey, Miguel Navarro, Michael P Pollastri   +15 more
doaj   +1 more source

Treatment of Depression in Rats Exposed To Chronic Unpredictable Mild Stress Using Synthetic Derivatives of Isatin [PDF]

, 2020
This study highlights the possible interaction between stress and immune-inflammatory pathways in the pathogenesis of depression and suggests an animal model that addresses these pathways.
Ajin, P Kurian
core  

In silico evaluation of the influence of N-alkylation and halogenation on isatin Schiff bases as potential inhibitors of bacterial DNA gyrase [PDF]

Pharmacia
Isatin Schiff bases are multifunctional pharmacophores with reported antimicrobial relevance, and structural modifications such as halogenation and N-alkylation may influence their interaction with bacterial targets.
Kaloyan Mihalev, Ivelin Iliev, Nadya Agova, Svetlana Georgieva   +3 more
doaj   +3 more sources

Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity

International Journal of Nanomedicine, 2014
Ayman El-Faham,1,2 Ahmed A Elzatahry,1,3 Zeid A Al-Othman,1 Elsayed Ahmed Elsayed4,5 1Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia,
El-Faham A, Elzatahry AA, Al-Othman ZA, Elsayed EA   +3 more
doaj