Results 81 to 90 of about 660,493 (200)

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease. [PDF]

J Enzyme Inhib Med Chem, 2023
ElNaggar MH, Elgazar AA, Gamal G, Hamed SM, Elsayed ZM, El-Ashrey MK, Abood A, El Hassab MA, Soliman AM, El-Domany RA, Badria FA, Supuran CT, Eldehna WM.   +12 more
europepmc   +1 more source

A novel schiff base of isatin derivatives: Synthesis, characterization, and biological activity [PDF]

Isatin Schiff bases are an important class of organic compounds that have garnered significant attention in the field of medical chemistry. They are derived from the condensation reaction between isatin, a cyclic compound, and various aromatic or ...
Gaafar, Mostafa M., Eltahan, Noura N.
core   +1 more source

Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors. [PDF]

Int J Mol Sci, 2022
Czeleń P, Skotnicka A, Szefler B.
europepmc   +1 more source

Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity

International Journal of Nanomedicine, 2014
Ayman El-Faham,1,2 Ahmed A Elzatahry,1,3 Zeid A Al-Othman,1 Elsayed Ahmed Elsayed4,5 1Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia,
El-Faham A, Elzatahry AA, Al-Othman ZA, Elsayed EA   +3 more
doaj  

Design and Optimization of Spiro-Isatin-Thiazolidinone Hybrids with Promising Anticancer Activity

Pharmaceuticals
Background: Cancer remains a leading cause of morbidity and mortality worldwide, and current therapies are limited by toxicity, cost, and resistance. Inhibition of the MDM2–p53 interaction is a promising anticancer strategy, as this pathway is frequently
Dmytro Khylyuk, Serhii Holota, Natalia Finiuk, Rostyslav Stoika, Tetyana Rumynska, Roman Lesyk   +5 more
doaj   +1 more source

Isatin derivatives as broad-spectrum antiviral agents: the current landscape. [PDF]

Med Chem Res, 2022
Elsaman T, Mohamed MS, Eltayib EM, Abdel-Aziz HA, Abdalla AE, Munir MU, Mohamed MA.   +6 more
europepmc   +1 more source

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19. [PDF]

Chem Zvesti, 2022
Ilyas M, Muhammad S, Iqbal J, Amin S, Al-Sehemi AG, Algarni H, Alarfaji SS, Alshahrani MY, Ayub K.   +8 more
europepmc   +1 more source

Synthesis, Characterization, Molecular Docking, and Antimicrobial Evaluation of New Acetylenic Mannich Bases of Isatin–Thiazole Derivatives

Iraqi Journal of Pharmaceutical Sciences
The isatin molecule is present in many natural substances, like plants and animals, and it is utilized to prepare compounds with various biological activities.
marwa hashim almusawi, May Mohammed Jawad Al-Mudhafar   +1 more
doaj   +1 more source

Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening. [PDF]

RSC Med Chem, 2023
Jiang X, Li J, Viayna A, Luque FJ, Woodson M, Jing L, Gao S, Zhao F, Xie M, Toth K, Tavis J, Tollefson AE, Liu X, Zhan P.   +13 more
europepmc   +1 more source

Recent advances in Isatin chemistry: Classical and modern synthetic strategies, mechanistic perspective, and biological applications of a privileged scaffold

Results in Chemistry
Isatin (1H-indole-2,3-dione) is a privileged scaffold that has attracted sustained interest because of its remarkable synthetic versatility and broad range of biological activities.
Seyed Mohammadreza Alavi, Mosayeb Akbari, Elham Mohammadi Mehr, Soodabeh Davaran, Rozita Yazzaf, Saghi Sepehri, Mohammad Mahdavi   +6 more
doaj   +1 more source