Results 81 to 90 of about 1,535,483 (232)

Synthesis of spiro[dihydropyridine-oxindoles] via three-component reaction of arylamine, isatin and cyclopentane-1,3-dione

Beilstein Journal of Organic Chemistry, 2013
A fast and convenient protocol for the synthesis of novel spiro[dihydropyridine-oxindole] derivatives in satisfactory yields was developed by the three-component reactions of arylamine, isatin and cyclopentane-1,3-dione in acetic acid at room temperature.
Yan Sun, Jing Sun, Chao-Guo Yan
doaj   +1 more source

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 ...
Loghman Firoozpour, Lixin Gao, Setareh Moghimi, Parvin Pasalar, Jamshid Davoodi, Ming-Wei Wang, Zahra Rezaei, Armin Dadgar, Hoda Yahyavi, Massoud Amanlou, Alireza Foroumadi   +10 more
doaj   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

New bactericide derived from Isatin for treating oilfield reinjection water

Chemistry Central Journal, 2012
Isatin, an extract from Strobilanthes cusia (Nees) Kuntze, was the base for synthesizing derivatives that were screened for antibacterial activity against oilfield water-borne bacteria. The bacterial groups are sulfate reducing, iron and total.
Chen Gang, Su Hui-jun, Zhang Min, Huo Fang, Zhang Jie, Hao Xiao-jiang, Zhao Jing-rui   +6 more
doaj   +1 more source

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions

Heliyon, 2020
A sequential multi-component reaction of the nitroketene dithioacetals, cysteamine hydrochloride, isatin and different CH-acids is described. This efficient method provides new functionalized thiazolo pyridine-fused spirooxindoles and thiazolo ...
Shima Nasri, Mohammad Bayat, Hassan Vasheghani Farahani, Solmaz Karami   +3 more
doaj   +1 more source

Isatin (indole-2,3-dione) in urine and tissues: detection and determination by gas chromatography—mass spectrometry

, 1991
A simple procedure based upon capillary column gas chromatography-mass spectrometry (GC—MS) is described for the detection and determination of isatin (indole-2,3-dione) in body fluids and tissues. After addition of 5-methylisatin as internal standard to
Watkins, P.J., Glover, V., Sandler, M., Goodwin, B.L., Clow, A., Przyborowska, A., Halket, J.   +6 more
core   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, Volume 15, Issue 4, April 2026.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Identifying New Isatin Derivatives with GSK-3β Inhibition Capacity through Molecular Docking and Bioassays

, 2020
The semi-synthesis of 11 isatin derivatives was achieved through bimolecular nucleophilic substitution and click chemistry. Seven new compounds were obtained.
Ligia R. Rodrigues (3070224), Carla S. Francisco (8527740), Karolinni B. Britto (8527737), Pedro A. B. Morais (8527749), Demetrius Profeti (8527746), Raphael Conti (1854166), Débora Ferreira (3404339), Warley S. Borges (2196742), Bárbara J. P. Borges (8527743), Valdemar Lacerda Jr. (5885402)   +9 more
core   +1 more source

Progress and Prospects of Sustainable Textile Processing Through Immobilized Enzyme Systems

ChemistrySelect, Volume 11, Issue 16, 27 April 2026.
The review presents recent advances in the use of immobilized enzymes for sustainable textile processing, detailing mechanisms that enhance stability, activity, and recyclability. It surveys applications in desizing, scouring, bleaching, bio‑polishing, and surface modification and examines their role in circular production.
Mohammad Neaz Morshed, Md. Reazuddin Repon, Rony Mia, Sakil Mahmud   +3 more
wiley   +1 more source

Forward genetic screening of mutants of the wild diploid ancestor Nicotiana sylvestris identifies aspartate oxidase 2 as a key gene for nicotine biosynthesis in cultivated allotetraploid tobacco (Nicotiana tabacum)

The Plant Journal, Volume 126, Issue 1, April 2026.
SUMMARY Tobacco (Nicotiana tabacum) is one of the most important commercial crops. It is an allotetraploid with two subgenomes derived from two wild diploid species: the maternal ancestor Nicotiana sylvestris and the paternal ancestor Nicotiana tomentosiformis.
Takanori Takeuchi, Hisashi Udagawa, Masao Arai, Ryo Nishiguchi, Tsubasa Yoshikiyo, Tomoyuki Tajima, Hiroshi Magome, Yoshimitsu Takakura   +7 more
wiley   +1 more source