Results 61 to 70 of about 1,535,483 (232)

Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect

Scientific Reports
Sixteen isatin-based hydrazone derivatives (IS1–IS16) were synthesized and assessed for their ability to inhibit monoamine oxidases (MAOs). All the molecules showed improved inhibitory MAO-B activity compared to MAO-A.
Sunil Kumar, J. Oh, Prabitha Prabhakaran, Abhimanyu Awasti, Hoon Kim, Bijo Mathew   +5 more
semanticscholar   +1 more source

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study.

Bioorganic chemistry (Print), 2020
Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included cholinesterase (ChE) inhibition and β-amyloid (Aβ) peptide anti-aggregation.
C. Marques, Ó. López, Donatella Bagetta, Elisabete P. Carreiro, Sabrina Petralla, M. Bartolini, M. Hoffmann, S. Alcaro, Barbara Monti, M. Bolognesi, Michael Decker, J. Fernández-Bolaños, A. Burke   +12 more
semanticscholar   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Green one-pot, four-component synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives using amino-functionalized nanoporous silica SBA-15 under solvent-free conditions [PDF]

Journal of the Serbian Chemical Society, 2015
Propylamine functionalized nanoporous silica (SBA-Pr-NH2) has been used as an efficient heterogeneous solid basic nanoreactor in the synthesis of 6'-amino-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one derivatives 5 through one-pot, four ...
Ziarani Ghodsi Mohammadi, Rahimifard Mahshid, Nouri Fatemeh, Badiei Alireza   +3 more
doaj   +1 more source

Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions

Heliyon, 2022
An efficient and facile one-pot, five-component reaction for the synthesis of 2,6-diamino-1-alkyl-2-oxospiro[indoline-3,4′-thiopyran]-3,5-dicarbonitrile derivatives has been reported by a reaction between primary amines, carbon disulfide, malononitrile ...
F. Matloubi Moghaddam, Bagher Aghamiri
doaj   +1 more source

A survey on the characterization and biological activity of isatin derivatives [PDF]

Journal of the Serbian Chemical Society, 2020
The derivatives of isatin have already been known to display a variety of biological activities. Therefore, the studies on their activity and its relation to structure have recently become a popular subject for investigation.
Drmanić Saša Ž., Petrović Predrag, Brkić Dominik R., Marinković Aleksandar D., Nikolić Jasmina B.   +4 more
doaj   +1 more source

Supramolecular Chiral Assembly of Open‐Shell Quinoids With Chiral Additives and Their Spin‐Dependent Transport in Magneto Field‐Effect Transistors

Small, EarlyView.
Open‐shell quinoids with intrinsic spins are assembled into chiral supramolecular structures via blending with chiral additives. Thermal annealing induces stable co‐crystallization, leading to a 30‐fold amplification of chirality (gabs = 1.23 × 10−2). Significantly, this study represents the first integration of spin‐possessing chiral assemblies into ...
Younghyo Kim, Jeongwoo Beak, Yunseul Kim, Seungrae Cho, Byungho Park, Kyoungtae Hwang, Kihyeun Kim, David H. Waldeck, Minwoo Lee, Taesun Yun, Chang‐Lyoul Lee, Dong‐Yu Kim   +11 more
wiley   +1 more source

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity

Molecules, 2022
Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis.
Francesca Bonvicini, Alessandra Locatelli, Rita Morigi, Alberto Leoni, Giovanna Angela Gentilomi   +4 more
doaj   +1 more source

Urea Derivative Catalyzed Enantioselective Hydroxyalkylation of Hydroxyindoles with Isatins [PDF]

Molecules, 2019
The enantioselective transformations of indoles preferentially take place in the more-reactive azole ring. However, the methods for the enantioselective functionalization of the indole benzene ring are scarce. In this paper, a series of bifunctional (thio)urea derivatives were used to organocatalyze the enantioselective Friedel-Crafts hydroxyalkylation
Hao Wu, Liming Wang, Junwei Zhang, Ying Jin   +3 more
openaire   +3 more sources

Ultrasound‐Assisted Synthesis and Comprehensive Characterization of Nanosized VO(II), Fe(III), and Ru(III) Complexes: From Density Functional Theory/Nonlinear Optical Properties to Pharmaceutical Applications and Docking Insights

ChemistryOpen, Volume 15, Issue 6, June 2026.
Ultrasound‐assisted synthesis enabled the formation of ultrafine hydrazone‐based metal complexes with controlled nanostructures and enhanced stability. Density functional theory revealed optimized geometries and electronic properties. The nanosized complexes exhibited superior antimicrobial, anticancer, and antioxidant activities, supported by ...
R. A. El‐Kasaby, Eida S. Al‐Farraj, Senem Akkoc, Amal H. Alsehli, Maher Fathalla, Samir A. Abdel‐Latif, Mashael A. Alghamdi, Ahmed M. Abu‐Dief   +7 more
wiley   +1 more source