Results 61 to 70 of about 3,007 (178)

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors. [PDF]

J Enzyme Inhib Med Chem, 2023
Shaldam MA, Almahli H, Angeli A, Badi RM, Khaleel EF, Zain-Alabdeen AI, Elsayed ZM, Elkaeed EB, Salem R, Supuran CT, Eldehna WM, Tawfik HO.   +11 more
europepmc   +1 more source

Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity

Drug Design, Development and Therapy, 2022
Refaie M Kassab,1 Sami A Al-Hussain,2 Nooran S Elleboudy,3 Amgad Albohy,4 Magdi EA Zaki,2 Khaled AM Abouzid,5,6 Zeinab A Muhammad7 1Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt; 2Department of Chemistry, Faculty of ...
Kassab RM, Al-Hussain SA, Elleboudy NS, Albohy A, Zaki MEA, Abouzid KAM, Muhammad ZA   +6 more
doaj  

Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents

Journal of Enzyme Inhibition and Medicinal Chemistry
Isatin, known as 1H-indole-2,3-dione, was originally recognised as a synthetic molecule until its discovery in the fruits of the cannonball tree, Couroupita guianensis.
Mohammad Altamimi, Saeed Ali Syed, Burak Tuzun, Mohammad Rashid Alhazani, Osamah Alnemer, Ahmed Bari   +5 more
doaj   +1 more source

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease. [PDF]

J Enzyme Inhib Med Chem, 2023
ElNaggar MH, Elgazar AA, Gamal G, Hamed SM, Elsayed ZM, El-Ashrey MK, Abood A, El Hassab MA, Soliman AM, El-Domany RA, Badria FA, Supuran CT, Eldehna WM.   +12 more
europepmc   +1 more source

In silico evaluation of the influence of N-alkylation and halogenation on isatin Schiff bases as potential inhibitors of bacterial DNA gyrase [PDF]

Pharmacia
Isatin Schiff bases are multifunctional pharmacophores with reported antimicrobial relevance, and structural modifications such as halogenation and N-alkylation may influence their interaction with bacterial targets.
Kaloyan Mihalev, Ivelin Iliev, Nadya Agova, Svetlana Georgieva   +3 more
doaj   +3 more sources

Über Isatin‐anile. II. Derivate des Thionaphthenchinons [PDF]

Berichte der deutschen chemischen Gesellschaft, 1910
n ...
openaire   +1 more source

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

PLoS Neglected Tropical Diseases, 2019
New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase ...
Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Veronica Gomez-Pérez, Luis Miguel Ruiz-Pérez, Domingo I Rojas-Barros, Francisco Gamarro, Dolores González-Pacanowska, María S Martínez-Martínez, Pilar Manzano, Lori Ferrins, Conor R Caffrey, Miguel Navarro, Michael P Pollastri   +15 more
doaj   +1 more source

Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors. [PDF]

Int J Mol Sci, 2022
Czeleń P, Skotnicka A, Szefler B.
europepmc   +1 more source

Crystal structure and Hirshfeld analysis of trans-bis(5-fluoroindoline-2,3-dione 3-oximato-κ2O2,N3)-trans-bis(pyridine-κN)copper(II)

Acta Crystallographica Section E: Crystallographic Communications, 2018
The reaction in methanol of CuII acetate monohydrate with 5-fluoroisatin 3-oxime deprotonated with KOH in a 1:2 molar ratio and recrystallization from pyridine yielded the title compound, [Cu(C8H4FN2O2)2(C5H5N)2].
Ana Paula Lopes de Melo, Leandro Bresolin, Bianca Barreto Martins, Vanessa Carratu Gervini, Adriano Bof de Oliveira   +4 more
doaj   +1 more source

Synthesis and Evaluation of the Cytotoxic Activities of Some Isatin Derivatives

Chemical and Pharmaceutical Bulletin, 2013
A series of isatin derivatives, 1-butyl-5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (3a-d), 6-butyl-chloro/fluoro-6H-indolo[2,3-b]quinoxalines (4a-h), and 5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (5a-h) were synthesized and characterized by using Fourier transform (FT)-IR, (1)H- and (13)C-NMR spectroscopy, mass ...
Reddy, Sanapalli Subba, Pallela, Ramjee, Kim, Dong-Min, Won, Mi-Sook, Shim, Yoon-Bo   +4 more
openaire   +3 more sources