Results 41 to 50 of about 1,535,483 (232)

Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with molecular modeling simulations

RSC Advances, 2023
Recently, scientists developed a powerful strategy called “one drug-multiple targets” to discover vital and unique therapies to fight the most challenging diseases.
Ashraf S. Hassan, N. Morsy, W. Aboulthana, A. Ragab   +3 more
semanticscholar   +1 more source

QSAR and molecular docking studies of isatin and indole derivatives as SARS 3CLpro inhibitors

BMC Chemistry, 2023
The 3C-like protease (3CL^pro), known as the main protease of SARS-COV, plays a vital role in the viral replication cycle and is a critical target for the development of SARS inhibitor.
Niousha Soleymani, S. Ahmadi, Fereshteh Shiri, A. Almasirad   +3 more
semanticscholar   +1 more source

Synthesis and characterization of novel Mannich's bases incorporated with Ibuprofen an Biginelli Derivatives

Tikrit Journal of Pure Science, 2023
In this work, a series of novel Mannich's bases incorporated with Ibuprofen core and Biginelli derivatives have been reported. The synthesis process was dependent on linking Ibuprofen hydrazone with Isatin to Biginelli derivatives via methylene group of
Layth W. Abdullah, Hanaa K.Saleh, Mustafa R. Aeyyd   +2 more
doaj   +1 more source

Theoretical and experimental prediction of corrosion inhibition efficiency of isatin and its derivatives by DFT calculations and weight loss method: A comparative study [PDF]

Journal of the Serbian Chemical Society
The corrosion inhibition performance of isatin and its N1/C5 substituted derivatives were analyzed by DFT calculation (B3LYP, 6311g, dp) in gas phase and solvation method with the help of Gaussian 09W and Gaussian 16.
Joseph Xavier Raj Jone Celestina, Shenbagapushpam Muthumanickam, Vincent Arul Deepa, Shanmugaraj Priyadharsani, Raj Chakkaravarthy, Rajamohan Satheesh, Viruthachalam Ramasamy Raja   +6 more
doaj   +1 more source

Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

Open Chemistry, 2021
This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity.
Santoso Mardi, Fadlan Arif, Fahmi Muhammad Riza Ghulam, Rahmayanti Ardhana   +3 more
doaj   +1 more source

Combined 4D-QSAR and target-based approaches for the determination of bioactive Isatin derivatives

, 2021
The hybrid method of the Electron-Conformational Genetic Algorithm (EC-GA) was used to determine the pharmacophore groups and to estimate anticancer activity in isatin derivatives using a robust 4D-QSAR software (EMRE).
K. Sahin (11448581), E. Saripinar (11448584), S. Durdagi (11448587)   +2 more
core   +2 more sources

Synthesis, Antimicrobial, and Anticancer Activities of Novel Nitrofuran Derivatives

Journal of Chemistry, 2023
Keeping in view the varying therapeutic attributes of 5-nitrofuran and isatin derivatives, novel 5-nitrofuran‒isatin molecular hybrids (2, 5–7) were synthesized by standard protocols, characterized by various spectroscopic techniques, and eventually ...
Malik Suliman Mohamed, Khaled M. Elamin, Rawaf Alenazy, Eyman Mohamed Eltayib, Mona Timan Idriss, Noura A. A. Alhudaib, Tilal Elsaman, Magdi Awadalla Mohamed   +7 more
doaj   +1 more source

Synthesis, structure elucidation, antioxidant properties, and theoretical calculations of new Schiff bases–isatin derivatives

Research on chemical intermediates (Print)
Isatin-derived Schiff bases are the subject of many studies, finding wide application areas in polymer technology, pharmaceutical industry, and medicine.
T. K. Bakır, M. Çavuş, H. Muğlu, Hasan Yakan   +3 more
semanticscholar   +1 more source

Interaction Study of 1, 3 Substituted Isatin Derivatives with Anti Inflammatory Properties with Cyclooxygenase 1 and 2 Enzymes by Molecular Docking Method

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Inflammation as the body's defense response is accompanied with various diseases. Prostaglandins are major mediators of inflammation produced by the cyclooxygenase enzymes.
Elham Jafari, Farshid Hassanzadeh, Nahal khayambashi, Valiollah Hajhashemi   +3 more
doaj  

Electronic structure, reactivity, and predicted biological activity of halogenated isatin-pyridine Schiff bases: a DFT study [PDF]

Pharmacia
Isatin derivatives have been at the forefront of pharmaceutical research, displaying a wide range of biological activities, including antioxidant, antimicrobial, and anticancer properties. In this study, twelve isatin-pyridine Schiff bases were evaluated
Nikolay Toshev, Armina Abdollahi, Kaloyan Mihalev, Ivelin Iliev, Yordanka Uzunova, Vassil Delchev, Nadya Agova, Svetlana Georgieva   +7 more
doaj   +3 more sources