Results 31 to 40 of about 7,251 (220)

Isatin, regional distribution in rat brain and tissues

, 1990
Isatin has recently been identified in rat tissues and normal human urine, where it forms the major proportion of the endogenous monoamine oxidase inhibitor, tribulin.
Watkins, P.J., Sandler, M., Clow, A., Przyborowska, A., Halket, J.   +4 more
core   +1 more source

Isatin: identity with the purified endogenous monoamine oxidase inhibitor tribulin

, 1988
Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin.
Watkins, P.J., Glover, V., Sandler, M., Goodwin, B.L., Clow, A., Halket, J.   +5 more
core   +1 more source

Synthesis and spectroscopic analysis of Schiff Bases of Imesatin and Isatin derivatives

Journal of Applied Sciences and Environmental Management, 2016
A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported.
Olubunmi S. Oguntoye, Abdulmumeen A. Hamid, Gabriel S. Iloka, Sunday O. Bodede, Samson O. Owalude, Adedibu C. Tella   +5 more
doaj   +1 more source

Inhibitory potency of some isatin analogues on human monoamine oxidase A and B

, 1992
Isatin is an endogenous compound which acts as a selective inhibitor of monoamine oxidase (MAO) B. In this study a range of isatin analogues were tested for their in vitro inhibition of human MAO A and B.
Medvedev, A.E., Glover, V., Sandler, M., Goodwin, B.L., Clow, A., Halket, J.   +5 more
core   +1 more source

The relationship between isatin and monoamine oxidase-B inhibitory activity in urine

, 1996
We have investigated the correlation between urinary isatin concentration and MAO-B inhibitory activity. A sensitive enzyme-linked immunosorbent assay (ELISA) for the measurement of isatin in urine was developed.
Evans, P., Pang, F.Y., Bristow, M., Hucklebridge, F., Clow, A., Doyle, A., Forster, G., Tan, K.   +7 more
core   +1 more source

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni   +9 more
doaj   +1 more source

Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration

, 1989
Isatin has recently been identified in rat tissues and normal human urine where it constitutes the major part of the endogenous monoamine oxidase inhibitor, tribulin.
Davidson, J., Watkins, P.J., Glover, V., Sandler, M., Clow, A., Halket, J., Milton, A.S.   +6 more
core   +1 more source

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, EarlyView.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source

Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain

, 1991
The effects of i.p. injection of 3 aromatic amino acids and two anxiogenic agents on rat brain isatin concentration and tribulin (endogenous monoamine oxidase inhibitor) activity were investigated.
Bhattacharya, S.K., Glover, V., Sandler, M., Clow, A., Przyborowska, A., Halket, J.   +5 more
core   +1 more source

Mesityl‐Substituted Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxalines: Synthesis, Functionalization, Photophysical, and Electrochemical Properties

European Journal of Organic Chemistry, EarlyView.
Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxaline with a mesityl group as a solubilizing group was synthesized. By synthesizing derivatives in which various functional groups were introduced into two electronically distinct sites, the pyrrole nitrogen atom and the azulene five‐membered ring, we were able to reveal that the photophysical and electrochemical ...
Ryuta Sekiguchi, Hiroki Mizuno, Ikumi Uchiyama, Souta Yuruka, Atsuya Shimizu, Taku Shoji, Shunji Ito   +6 more
wiley   +1 more source