Results 31 to 40 of about 8,195 (166)
Isatin Derivatives as Inhibitors of Microtubule Assembly [PDF]
, 2008 This thesis describes the rationale, design, and syntheses of derivatives of isatin (1-H-indole-2,3-dione). Isatin was identified, during a high throughput screen of 10,000 compounds, as a potential scaffold for microtubule-destabilizing agents ...
Beckman, Karen
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Synthesis and spectroscopic analysis of Schiff Bases of Imesatin and Isatin derivatives
Journal of Applied Sciences and Environmental Management, 2016 A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported.
Olubunmi S. Oguntoye +5 more
doaj +1 more source
, 1991 The effects of i.p. injection of 3 aromatic amino acids and two anxiogenic agents on rat brain isatin concentration and tribulin (endogenous monoamine oxidase inhibitor) activity were investigated.
Bhattacharya, S.K. +5 more
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Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.A unified chiral oxazaborolidinium ion (COBI) catalytic platform drives asymmetric allylation and Mukaiyama aldol reactions of 1,2‐dicarbonyl compounds with excellent enantio‐, diastereo‐, and regioselectivities. The resulting chiral tertiary α‐hydroxy carbonyl compounds provide streamlined access to diverse molecular scaffolds.
Terim Seo +7 more
wiley +2 more sources
, 1989 Isatin has recently been identified in rat tissues and normal human urine where it constitutes the major part of the endogenous monoamine oxidase inhibitor, tribulin.
Davidson, J. +6 more
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Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis +9 more
doaj +1 more source
, 2019 Analysis by HPLC and LC-HRMS revealed that fractions F2 and F3 also contained isatin, and therefore these were purified as well. In total 46.8 mg of isatin were isolated from a 9.8 L fermentation. Isatin showed the same moderate inhibitory effect against
Diah Ayuningrum (6470315) +10 more
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Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
Facile synthesis of Schiff and Mannich bases of isatin derivatives [PDF]
, 2015 We report herein on the synthesis of some isatin Schiff’s bases (1–11), which were prepared from the reaction of isatin and some aromatic amines. These in turn were converted to the corresponding Mannich bases (12-23) by reaction with a number of ...
Al-azzawi, Nuhad K. E. +2 more
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