Results 51 to 60 of about 8,195 (166)

Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development [PDF]

Makedonsko Farmacevtski Bilten
Isatin-based hybrids have emerged as promising candidates in medicinal chemistry due to their broad biological activities and structural versatility. This review outlines recent developments (2020–2025) in the design of isatin hybrids targeting cancer ...
Aleksandar Dimkovski, Evgenija Mihajloska, Ana Poceva Panovska   +2 more
doaj   +1 more source

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

Molecules, 2022
We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and Q8a–h), in connection with our research interest in developing novel isatin-bearing anti-tubercular candidates.
Mohamed A. Abdelrahman, Hadia Almahli, Tarfah Al-Warhi, Taghreed A. Majrashi, Marwa M. Abdel-Aziz, Wagdy M. Eldehna, Mohamed A. Said   +6 more
doaj   +1 more source

Isatin (indole-2,3-dione) in urine and tissues: detection and determination by gas chromatography—mass spectrometry

, 1991
A simple procedure based upon capillary column gas chromatography-mass spectrometry (GC—MS) is described for the detection and determination of isatin (indole-2,3-dione) in body fluids and tissues. After addition of 5-methylisatin as internal standard to
Watkins, P.J., Glover, V., Sandler, M., Goodwin, B.L., Clow, A., Przyborowska, A., Halket, J.   +6 more
core   +1 more source

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source

Computational Screening and Synthesis of Some Isatin-Thiadiazole Hybrids Potentially Targeting Diabetes

Chemistry Proceedings
This study explores the design, synthesis and preliminary in silico screening of novel thiadiazole-isatin hybrid derivatives targeting diabetes mellitus.
Monika, Nishtha Shalmali, Priyanshu
doaj   +1 more source

Solvatochromism of isatin based Schiff bases: An LSER and LFER study [PDF]

Journal of the Serbian Chemical Society, 2016
The derivatives of isatin have already been reported to show a variety of biological activities. However, there has been no report on solvatochromic effect of isatin derivatives so far, and that could be of interest to study and relate to their ...
Brkić Dominik R., Božić Aleksandra R., Nikolić Vesna D., Marinković Aleksandar D., Elshaflu Hana, Nikolić Jasmina B., Drmanić Saša Ž.   +6 more
doaj   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

1-Tetradecylindoline-2,3-dione

Acta Crystallographica Section E, 2010
In the title N-alkyl isatin, C22H33NO2, the isatin moiety is planar (r.m.s. deviation = 0.03 Å). The tetradecyl substituent has all torsion angles in an antiperiplanar conformation.
Khalil Mamari, Hafid Zouihri, El Mokhtar Essassi, Seik Weng Ng   +3 more
doaj   +1 more source

1H‑1,2,3-Triazole-Tethered Isatin–Ferrocene and Isatin–Ferrocenylchalcone Conjugates: Synthesis and in Vitro Antitubercular Evaluation

, 2016
A Cu-mediated azide–alkyne cycloaddition protocol has been employed for the synthesis of 16 different triazoles to probe the antitubercular structure–activity relationships within the isatin–ferrocene–triazole conjugate family.
Yann Guérardel (1867114), Vipan Kumar (828014), Christophe Biot (735982), Laurent Kremer (37664), Kewal Kumar (1867111), Séverine Carrère-Kremer (1867117)   +5 more
core   +1 more source

1-Decylindoline-2,3-dione

Acta Crystallographica Section E, 2010
In the title N-alkyl isatin, C18H25NO2, the isatin moiety is almost planar (r.m.s. deviation = 0.03 Å). C—C—C—C torsion angles of the decyl substituent indicate an all-antiperiplanar conformation.
Khalil Mamari, Hafid Zouihri, El Mokhtar Essassi, Seik Weng Ng   +3 more
doaj   +1 more source