Results 51 to 60 of about 7,251 (220)

Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development [PDF]

Makedonsko Farmacevtski Bilten
Isatin-based hybrids have emerged as promising candidates in medicinal chemistry due to their broad biological activities and structural versatility. This review outlines recent developments (2020–2025) in the design of isatin hybrids targeting cancer ...
Aleksandar Dimkovski, Evgenija Mihajloska, Ana Poceva Panovska   +2 more
doaj   +1 more source

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

Molecules, 2022
We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and Q8a–h), in connection with our research interest in developing novel isatin-bearing anti-tubercular candidates.
Mohamed A. Abdelrahman, Hadia Almahli, Tarfah Al-Warhi, Taghreed A. Majrashi, Marwa M. Abdel-Aziz, Wagdy M. Eldehna, Mohamed A. Said   +6 more
doaj   +1 more source

Cytotoxicity study of some indophenines and isatin derivatives [PDF]

Bangladesh Journal of Pharmacology, 2008
Eight indophenines were synthesized for the interest of studying biological activity especially for cytotoxicity. The cytotoxicity of some indophenines and some isatin derivatives was studied by the brine shrimp lethality bioassay.
Md. Mahbubul Hoque, Md. Rabiul Islam
doaj   +2 more sources

Solvatochromism of isatin based Schiff bases: An LSER and LFER study [PDF]

Journal of the Serbian Chemical Society, 2016
The derivatives of isatin have already been reported to show a variety of biological activities. However, there has been no report on solvatochromic effect of isatin derivatives so far, and that could be of interest to study and relate to their ...
Brkić Dominik R., Božić Aleksandra R., Nikolić Vesna D., Marinković Aleksandar D., Elshaflu Hana, Nikolić Jasmina B., Drmanić Saša Ž.   +6 more
doaj   +1 more source

REAKSI ISATIN DENGAN 4-BROMOANILINA DAN ISATIN DENGAN 3-BROMOANILINA [PDF]

, 2014
Reaksi isatin dengan 2,5-dimetoksianilina dengan perbandingan 1:1 telah dikaji guna memperoleh 3-(2,5- dimetoksifenilimino)-1,3-dihidroindol-2-on, tapi yang diperoleh adalah 3,3-bis(4-amino-2,5-dimetoksifenil)-1,3-dihidroindol-2-on sehingga dilakukan
SAGITA, DEVIN ARI
core  

Antidiabetic and Cytotoxicity Studies of Novel Quinazolinone–1,3,4‐Thiadiazole Molecular Hybrids

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
ABSTRACT In the treatment of diabetes mellitus (DM), inhibition of carbohydrate‐hydrolysing enzymes, such as α‐amylase, has emerged as a promising therapeutic strategy. In the present study, a series of quinazolinone‐1,3,4‐thiadiazole molecular hybrids were designed, synthesized and biologically evaluated for their antidiabetic potential.
Prishani Kisten, Pule Seboletswe, Gobind kumar, Nontobeko Gcabashe, Neha Manhas, Ankit, Almahi Idris, Md. Shahidul Islam, René Khan, Parvesh Singh   +9 more
wiley   +1 more source

1-Tetradecylindoline-2,3-dione

Acta Crystallographica Section E, 2010
In the title N-alkyl isatin, C22H33NO2, the isatin moiety is planar (r.m.s. deviation = 0.03 Å). The tetradecyl substituent has all torsion angles in an antiperiplanar conformation.
Khalil Mamari, Hafid Zouihri, El Mokhtar Essassi, Seik Weng Ng   +3 more
doaj   +1 more source

Antidiabetic Evaluation of Thiosemicarbazone Analogs Through α‐Amylase Inhibition Complemented With Computational Studies

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Thiosemicarbazones were evaluated for antidiabetic activity via α‐amylase inhibition. Compound 6g showed two‐fold greater potency than acarbose. Benzaldehyde‐ and ketone‐derived analogues were most active, while isatin and furan derivatives were less effective. Several compounds displayed antioxidant activity. Docking highlighted hydrogen bonding and π–
Neha Manhas, Gobind Kumar, Ankit, Nagaraju Kerru, Pule Seboletswe, Nontobeko Gcabashe, Almahi Idris, Md. Shahidul Islam, Talent Makhanya, Parvesh Singh   +9 more
wiley   +1 more source

Characterization of the Orphan Cytochrome P450 CYP107J1 From Bacillus subtilis Through Peroxygenase Activity Engineering

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
The orphan cytochrome P450 CYP107J1 with unknown redox partners was rationally modified into H2O2‐driven form. The QE (E251Q/T252E) mutant produced valuable chemicals by simply mixing the enzyme with substrate and H2O2. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising ...
Hideki Kato, Takafumi Hashimoto, Tuhin Das, Daniel Z. Doherty, Stephen G. Bell, Toshiki Furuya   +5 more
wiley   +1 more source

1-Decylindoline-2,3-dione

Acta Crystallographica Section E, 2010
In the title N-alkyl isatin, C18H25NO2, the isatin moiety is almost planar (r.m.s. deviation = 0.03 Å). C—C—C—C torsion angles of the decyl substituent indicate an all-antiperiplanar conformation.
Khalil Mamari, Hafid Zouihri, El Mokhtar Essassi, Seik Weng Ng   +3 more
doaj   +1 more source