Membrane-forming phospholipids allosterically modulate native-state prolyl isomerization in a CNG channel. [PDF]
Protein SciAbstract Ion channel activity is intricately linked to the surrounding lipid environment, yet the molecular effects of lipid‐mediated regulation remain largely understudied. Here, we show that membrane‐forming phospholipids, which are known to modulate the activity of the cyclic nucleotide‐gated channel SthK from Spirochaeta thermophila, exhibit ...
Newton AJ +3 more
europepmc +2 more sources
Mesenchymal Stem Cells Reduce Inflammation in a Mouse Model of Lyme Arthritis. [PDF]
Stem Cells IntLyme disease (LD), a zoonotic infectious disease caused by Borrelia burgdorferi (B. burgdorferi), can affect various organs, including the skin, heart, nervous system, and joints. Lyme arthritis (LA) is the most common and severe late‐stage presentation of LD, often presenting with intermittent joint swelling and pain.
Ma W +23 more
europepmc +2 more sources
Analysis of 1,000+ Type-Strain Genomes Substantially Improves Taxonomic Classification of Alphaproteobacteria. [PDF]
, 2020 The class Alphaproteobacteria is comprised of a diverse assemblage of Gram-negative bacteria that includes organisms of varying morphologies, physiologies and habitat preferences many of which are of clinical and ecological importance ...
Gronow, Sabine +9 more
core +2 more sources
Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel
Nature Communications, 2020 SthK, a cyclic nucleotide-gated ion channel from Spirochaeta thermophila activates slowly upon cAMP increase. Here, authors investigate cAMP-induced activation in purified SthK channels using stopped-flow assays and enzymatic catalysis and reveal that ...
Philipp A. M. Schmidpeter +2 more
doaj +1 more source
Chemotaxis in Spirochaeta aurantia [PDF]
Journal of Bacteriology, 1977 Cell of Spirochaeta aurantia M1 suspended in isotropic buffer solution swam in nearly straight lines and appeared to spin around their longitudinal axis. Occasionally, cells stopped and flexed, and then resumed translational motility, usually in a different direction. The average cell velocity was 26 micron/s.
E P, Greenberg, E, Canale-Parola
openaire +2 more sources
Bacterial symbionts of the precious coral Corallium rubrum are differentially distributed across colony‐specific compartments and differ among colormorphs [PDF]
Environ Microbiol RepThe distribution and functions of the symbiotic microbes of the precious coral Corallium rubrum are unknown. We optimised coral dissection protocols by using RNAlater, and employed 16S rRNA metabarcoding to characterise the microbiota in different compartments (polyps, coenenchyme, skeleton) and in three colormorphs (red, pink, white).
van de Water J +2 more
europepmc +2 more sources
A possible unique ecosystem in the endoglacial hypersaline brines in Antarctica
Scientific Reports, 2023 Here, we present the results related to a new unique terrestrial ecosystem found in an englacial hypersaline brine found in Northern Victoria Land (Antarctica).
M. Guglielmin +10 more
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Lyme Disease and New Molecular Biological Detection Methods [PDF]
Novelty in Clinical Medicine, 2023 Molecular biology plays an important role in understanding the structures, functions and internal controls within each cell. All this can be used to diagnose the diseases, effectively target new medicines and better understand cellular physiology.
Ali Choopani +3 more
doaj +1 more source
Chemotaxis mutants of Spirochaeta aurantia [PDF]
Journal of Bacteriology, 1989 Five Spirochaeta aurantia chemotaxis mutants were isolated. One mutant (the che-101 mutant) never reversed, one (the che-200 mutant) flexed predominantly, two (the che-300 and che-400-1 mutants) exhibited elevated reversal frequencies, and one (the che-400 mutant) exhibited chemotactically unstimulated behavior similar to that of the wild-type strain ...
K, Fosnaugh, E P, Greenberg
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Description of Treponema azotonutricium sp. nov. and Treponema primitia sp. nov., the First Spirochetes Isolated from Termite Guts [PDF]
, 2004 Long after their original discovery, termite gut spirochetes were recently isolated in pure culture for the first time. They revealed metabolic capabilities hitherto unknown in the Spirochaetes division of the Bacteria, i.e., H2 plus CO2 acetogenesis (J.
Breznak, John A. +2 more
core +1 more source