Results 51 to 60 of about 34,497 (254)

Experience collecting interim data on mortality: an example from the RALES study. [PDF]

, 2001
INTRODUCTION: The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary endpoint was death from all causes.
Palensky, Jolie, Boissel Jean-Pierre, Desmond Julian, Pocock, Stuart, Pocock Stuart, Curt D Furberg, Janet Wittes, Barbara Roniker, Stuart Pocock, Julian Desmond, Palensky Jolie, Furberg Curt D, Roniker Barbara, Jean-Pierre Boissel, Jolie Palensky, Furberg, Curt D, Asner Debra, Debra Asner, Wittes, Janet, Wittes Janet, Julian, Desmond, Asner, Debra, Kulbertus Henri, Kulbertus, Henri, Henri Kulbertus, Roniker, Barbara, Boissel, Jean-Pierre   +26 more
core   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Novel approach to adherence assessment based on parent drug and metabolite pharmacokinetics: pilot study with spironolactone

Biomedical Papers
Aim. The aim of this study was to evaluate adherence to spironolactone in a group of unselected patients with arterial hypertension by analysis of measured serum spironolactone and canrenone concentrations according to a proposed two-step decision scheme
Alena Pilkova, Martin Sima, Jan Miroslav Hartinger, Thi Minh Phuong Nikrynova Nguyen, Vera Maresova, Ivana Kurcova, Ondrej Slanar, Jiri Widimsky   +7 more
doaj   +1 more source

The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

Clinical, Cosmetic and Investigational Dermatology, 2023
Chaofan Wang, Yimei Du, Lingbo Bi, Xuewen Lin, Min Zhao, Weixin Fan Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaCorrespondence: Weixin Fan, Department of Dermatology, The ...
Wang C, Du Y, Bi L, Lin X, Zhao M, Fan W
doaj  

Spironolactone for the treatment of acne in women, a retrospective study of 110 patients

International Journal of Women's Dermatology, 2017
Background: There is limited evidence on the safety and efficacy of spironolactone in the treatment of women with acne. Thus, for many dermatologists spironolactone remains an alternative rather than a mainstay treatment for female patients with acne ...
J.W. Charny, BS, J.K. Choi, MD, PhD, W.D. James, MD   +2 more
doaj   +1 more source

Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Aortic stiffness is an independent predictor of cardiovascular events in patients with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and associated with adverse outcomes.
Sudeep R. Aryal, Mohammed Siddiqui, Oleg F. Sharifov, Megan D. Coffin, Bin Zhang, Krishna K. Gaddam, Himanshu Gupta, Thomas S. Denney, Louis J. Dell'Italia, Suzanne Oparil, David A. Calhoun, Steven G. Lloyd   +11 more
doaj   +1 more source

Acneiform eruption associated with Janus kinase inhibitors in pediatric inflammatory bowel disease: Case series and clinical management guidance [PDF]

JPGN Rep
Abstract Janus kinase inhibitors (JAKi) are increasingly used for refractory inflammatory bowel disease (IBD) in pediatric patients but are associated with significant dermatologic adverse effects. Acneiform eruptions have been reported in up to 30% of adults, with a greater incidence suspected in adolescents.
Tran T, Park D, Ahmad R, Goel M, Verstraete S, Ali S.   +5 more
europepmc   +2 more sources

A comparison between spironolactone and spironolactone plus finasteride in the treatment of hirsutism

, 2004
Objective: To compare the clinical efficacy and safety of the combination of spironolactone (100 mg/day) plus finasteride (5 mg/day) and spironolactone (100 mg/day) alone in the treatment of ...
Sahin, Yılmaz, Kelestimur, F, Everest, Hatice, Bayram, Fahri, Unluhizarci, Kürşad   +4 more
core   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source

Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Spironolactone may have prognostic benefit in selected patients with heart failure with preserved ejection fraction. This study assessed the myocardial tissue effects of spironolactone in heart failure with preserved ejection fraction. Methods
Adam K. McDiarmid, Peter P. Swoboda, Bara Erhayiem, Katrina A. Bounford, Petra Bijsterveld, Keith Tyndall, Graham J. Fent, Pankaj Garg, Laura E. Dobson, Tarique A. Musa, James R. J. Foley, Klaus K. Witte, Mark T. Kearney, John P. Greenwood, Sven Plein   +14 more
doaj   +1 more source