Results 31 to 40 of about 34,497 (254)

Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms

Frontiers in Cardiovascular Medicine, 2023
BackgroundAbdominal aortic aneurysms (AAA) are characterized by vascular inflammation and remodeling that can lead to aortic rupture resulting in significant mortality. Pannexin-1 channels on endothelial cells (ECs) can modulate ATP secretion to regulate
Zachary Ladd, Gang Su, Joseph Hartman, Guanyi Lu, Sara Hensley, Gilbert R. Upchurch, Ashish K. Sharma   +6 more
doaj   +1 more source

Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO/PKG pathway in the bile-duct-ligated rat. [PDF]

PLoS ONE, 2012
OBJECTIVE: Aldosterone, one of the main peptides in renin angiotensin aldosterone system (RAAS), has been suggested to mediate liver fibrosis and portal hypertension.
Wei Luo, Ying Meng, Hong-Li Ji, Chun-Qiu Pan, Shan Huang, Chang-Hui Yu, Li-Ming Xiao, Kai Cui, Shu-Yuan Ni, Zhen-Shu Zhang, Xu Li   +10 more
doaj   +1 more source

Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies. [PDF]

, 2022
Evidence suggests that spironolactone, a nonselective mineralocorticoid receptor (MR) antagonist, modulates alcohol seeking and consumption. Therefore, spironolactone may represent a novel pharmacotherapy for alcohol use disorder (AUD). In this study, we
Koob, George F, McGinn, M Adrienne, Fiellin, David A, Leggio, Lorenzo, Marchette, Renata CN, Vendruscolo, Leandro F, Douglass, Eliza A, Justice, Amy C, Sanfilippo, Jenna E, Gonzalez, Luis A, Elvig, Sophie K, Chuong, Vicky, Tunstall, Brendan J, Farokhnia, Mehdi, Rentsch, Christopher T   +14 more
core   +1 more source

Effect of spironolactone on pain responses in mice [PDF]

, 2010
The effects of spironolactone, a non-selective aldosterone antagonist, were examined on thermally-induced pain using the hot-plate and tail-flick tests, on hemogenic pain induced by intraplantar capsaicin, on electrically-induced pain, on visceral ...
Baiuomy, Ayman R., Nada, Somaia A., Abdel-Salam, Omar M.E.   +2 more
core   +1 more source

Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells

Journal of Pharmacological Sciences, 2006
.: We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin
Miura Ryuzea, Nakamura Kazufumi, Miura Daiji, Miura Aya, Hisamatsu Kenichi, Kajiya Masahito, Nagase Satoshi, Morita Hiroshi, Kusano Kengo Fukushima, Ohe Tohru, Ishihara Kazuhiko   +10 more
doaj   +1 more source

Water-soluble β-Cyclodextnns in Paediatnc Oral Solutions of Spironolactone: Preclinical Evaluation of Spironolactone Bioavailability from Solutions of β-Cyclodextrin Derivatives in Rats

, 1998
Water-soluble derivatives of β-cyclodextrin have been considered for solubilization of spironolactone in the formulation of a safe liquid preparation for premature infants. The oral absorption of spironolactone was studied in rats to evaluate the need to
Hans Lennernäs, Ann M Kaukonen, Jukka-Pekka Mannermaa   +2 more
core   +1 more source

Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study

Acta Dermato-Venereologica
Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne.
Brigitte Dréno, Jean-Michel Nguyen, Ewa Hainaut, Laurent Machet, Marie-Thérèse Leccia, Nathalie Beneton, Jean-Paul Claudel, Philippe Célérier, Marie Le Moigne, Sarah Le Naour, Florence Vrignaud, Alexandra Poinas, Cécile Dert, Aurélie Boisrobert, Laurent Flet, Simon Korner, Amir Khammari   +16 more
doaj   +1 more source

Add-on spironolactone as antagonist of the NRG1-ERBB4 signaling pathway for the treatment of schizophrenia: Study design and methodology of a multicenter randomized, placebo-controlled trial

Contemporary Clinical Trials Communications, 2020
Background: Preclinical studies recently showed that the mineralocorticoid antagonist spironolactone acts also as an antagonist of the NRG1-ERBB4 signaling pathway and improves schizophrenia-like behaviour in Nrg1 transgenic mouse model.
Alkomiet Hasan, Astrid Roeh, Stefan Leucht, Berthold Langguth, Maximilian Hansbauer, Tatiana Oviedo-Salcedo, Sophie K. Kirchner, Irina Papazova, Lisa Löhrs, Elias Wagner, Isabel Maurus, Wolfgang Strube, Moritz J. Rossner, Michael C. Wehr, Ingrid Bauer, Stephan Heres, Claudia Leucht, Peter M. Kreuzer, Stephanie Zimmermann, Thomas Schneider-Axmann, Thomas Görlitz, Susanne Karch, Silvia Egert-Schwender, Beate Schossow, Philipp Rothe, Peter Falkai   +25 more
doaj   +1 more source

Efficacy and safety of iodized lecithin tablets versus spironolactone in alleviating central serous retinopathy among Chinese patients with uncontrolled diabetes

Pakistan Journal of Pharmaceutical Sciences, 2023
To compare the effectiveness and safety of spironolactone versus lecithin-bound iodine in patients with central serous retinopathy (CSR). Chinese diabetes patients aged>18 years with CSR with persistent increased level of subretinal fluid (SRF) were ...
Huihui Gu, Lijun Pu, Suqin Yu
doaj   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source