Results 31 to 40 of about 33,667 (245)

Influence of Spironolactone on Matrix Metalloproteinase-2 in Acute Decompensated Heart Failure

Arquivos Brasileiros de Cardiologia, 2015
Background: Matrix metalloproteinases (MMPs) are a family of enzymes important for the resorption of extracellular matrices, control of vascular remodeling and repair.
João Pedro Ferreira, Mário Santos, José Carlos Oliveira, Irene Marques, Paulo Bettencourt, Henrique Carvalho   +5 more
doaj   +1 more source

Hyperkalemia in women with acne exposed to oral spironolactone: A retrospective study from the RADAR (Research on Adverse Drug Events and Reports) program

International Journal of Women's Dermatology, 2019
Purpose: The necessity of serum potassium monitoring for healthy women who are prescribed spironolactone for acne has been debated. The aim of this study was to compare the incidence of hyperkalemia in women 18 to 45 years of age to that in women 46 to ...
Rebecca M. Thiede, Supriya Rastogi, Beatrice Nardone, Lauren M. Sadowsky, Stephanie M. Rangel, Dennis P. West, Bethanee J. Schlosser   +6 more
doaj   +1 more source

Effects of Spironolactone and Losartan on Diabetic Nephropathy in a Type 2 Diabetic Rat Model [PDF]

Diabetes & Metabolism Journal, 2011
BackgroundWhile there is an evidence that the anti-inflammatory properties of spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular endothelial growth factor (VEGF) expression in diabetic nephropathy have not been clearly ...
Mi Young Lee, Myoung Sook Shim, Bo Hwan Kim, Soon Won Hong, Ran Choi, Eun Young Lee, Soo Min Nam, Gun Woo Kim, Jang Yel Shin, Young Goo Shin, Choon Hee Chung   +10 more
doaj   +1 more source

Spironolactone and colitis: Increased mortality in rodents and in humans [PDF]

, 2012
Background: Crohn's disease causes intestinal inflammation leading to intestinal fibrosis. Spironolactone is an antifibrotic medication commonly used in heart failure to reduce mortality. We examined whether spironolactone is antifibrotic in the context
Higgins, Peter D.R., Gillespie, Brenda W., Johnson, Laura A., Govani, Shail M., Waljee, Akbar K., Peter D.R. Higgins, Joyce, Joel C., Shail M. Govani, Laura A. Johnson, Akbar K. Waljee, Joel C. Joyce, Brenda W. Gillespie   +11 more
core   +1 more source

Efficacy and Safety of Spironolactone in the Treatment of Resistant Hypertension：a Meta-analysis [PDF]

Zhongguo quanke yixue, 2022
BackgroundAs a special type of hypertension, resistant hypertension has complex etiology, is difficult to treat, and more likely to lead to target organ damage.
ZHANG Ping, ZOU Jing, GAO Cunzhou, WU Aiping, LI Rongshan
doaj   +1 more source

Unexpected Antiviral Activity of Spironolactone

, 2020
Epstein-Barr virus (EBV) is a human herpesvirus associated with clinical infections and several types of malignancies. Sankar Swaminathan, MD, and colleagues showed that a hypertension/heart failure drug, spironolactone, also has anti-EBV effects.
Swaminathan, S.; Verma, D.
core   +1 more source

Outcomes of Spironolactone Withdrawal in Dilated Cardiomyopathy With Improved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Background: The feasibility of spironolactone withdrawal in dilated cardiomyopathy patients with improved ejection fraction remains unknown. This study sought to determine whether spironolactone can be withdrawn safely in this circumstance.Methods ...
Yanjia Chen, Yanjia Chen, Zeping Qiu, Zeping Qiu, Jie Jiang, Xiuxiu Su, Fanyi Huang, Fanyi Huang, Jing Tang, Wei Jin, Wei Jin   +10 more
doaj   +1 more source

Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms

Frontiers in Cardiovascular Medicine, 2023
BackgroundAbdominal aortic aneurysms (AAA) are characterized by vascular inflammation and remodeling that can lead to aortic rupture resulting in significant mortality. Pannexin-1 channels on endothelial cells (ECs) can modulate ATP secretion to regulate
Zachary Ladd, Gang Su, Joseph Hartman, Guanyi Lu, Sara Hensley, Gilbert R. Upchurch, Ashish K. Sharma   +6 more
doaj   +1 more source

Spironolactone in dermatology:uses in acne and beyond

, 2020
Spironolactone is a synthetic aldosterone receptor antagonist, with a role off-label in various dermatological conditions. Its antiandrogenic properties make it suitable for diseases in which excess androgen production results in unwanted and ...
Searle, T. N., Al-Niaimi, F., Ali, Faisal R.   +2 more
core   +1 more source

Are beta-blockers needed in patients receiving spironolactone for severe chronic heart failure? An analysis of the COPERNICUS study

, 2006
BACKGROUND: The beneficial effects of beta-blockers and aldosterone receptor antagonists are now well established in patients with severe systolic chronic heart failure (CHF).
Rouleau, Jean-Lucien, Tendera, Michael, Packer, Milton, Katus, Hugo A., Roeker, Ellen B., Krum, Henry, Fowler, Michael B., Coats, Andrew J. S., Mohacsi, Paul, Rouleau, JL, Packer, M, Katus, HA, Krum, H, Mohacsi, P, Coats, AJ, Roecker, EB, Fowler, MB, Tendera, M, Carvedilol, Prospective Randomized Cumulative Survival (COPERNICUS) Study Gr   +18 more
core   +2 more sources